FYN antibody

Principal name

FYN antibody

Alternative names for FYN antibody

p59-Fyn, Protooncogene Syn, SLK, Proto-oncogene tyrosine-protein kinase Fyn

SwissProt ID

A0JNB0 (Bovin), A1Y2K1 (Pig), P06241 (Human), P13406 (Xenla), P39688 (Mouse), Q05876 (Chick), Q62844 (Rat)

Gene ID

2534 (FYN), 14360 (Fyn)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F)

Background of FYN antibody

Src is the human homolog of the v-Src gene of the Rous sarcoma virus, also called avian sarcoma virus or ASV. Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility and adhesion. Src-family kinases contain an amino terminal cell membrane anchor followed by an SH3 domain and an SH2 domain involved in modular association and activation, respectively. Src-family kinases are normally maintained in an inactive state and can be activated transiently during cellular events such as mitosis. Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization and membrane trafficking. Fyn and Lck kinases play a key role in T cell antigen receptor (TCR) signaling. The human Fyn gene maps to chromosome 6q21 and encodes a 537 amino acid protein.

General readings

1. Utting O, Priatel JJ, Teh SJ, Teh HS: p59fyn (Fyn) promotes the survival of anergic CD4-CD8- alpha beta TCR+ cells but negatively regulates their proliferative response to antigen stimulation. J Immunol. 2001 Feb 1;166(3):1540-6.
2. Talmor-Cohen A, Tomashov-Matar R, Tsai WB, Kinsey WH, Shalgi R: Fyn kinase-tubulin interaction during meiosis of rat eggs. Reproduction. 2004 Oct;128(4):387-93.
3. Hattori K, Uchino S, Isosaka T, Maekawa M, Iyo M, Sato T, Kohsaka S, Yagi T, Yuasa S: Fyn is required for haloperidol-induced catalepsy in mice. J Biol Chem. 2006 Mar 17;281(11):7129-35.
4. Wu HY, Hsu FC, Gleichman AJ, Baconguis I, Coulter DA, Lynch DR: Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems. J Biol Chem. 2007 Jul 13;282 (28):20075-87.
5. Filby A, Seddon B, Kleczkowska J, Salmond R, Tomlinson P, Smida M, Lindquist JA, Schraven B, Zamoyska R. Fyn regulates the duration of TCR engagement needed for commitment to effector function. J Immunol. 2007 Oct 1;179(7):4635-44.
6. Samayawardhena LA, Kapur R, Craig AW: Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells.
Blood. 2007 May 1;109(9):3679-86.
7. Makinodan E, Manabe T, Makinodan M, Yamauchi T, Matsuyoshi H, Sakumura R, Tatsumi K, Wanaka A. A novel role for Fyn: change in sphere formation ability in murine embryonic stem cells. Neuroscience. 2007 Jun 15;147(1):1-4.
8. Rivera J, Olivera A: A current understanding of Fc epsilon RI-dependent mast cell activation. Curr Allergy Asthma Rep. 2008 Mar;8(1):14-20.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

FYN antibody

WB Suggested Anti-FYN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

FYN antibody

Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and brain tissues (right) using FYN mouse mAb with DAB staining. Mouse IgG1 2A10 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

FYN antibody

Figure 3. Immunofluorescence staining of Fyn in human primary fibroblasts using anti-Fyn (FYN-01; green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue). Mouse IgG2b FYN-01 Purified Hu, Ms ICC/IF, IP, P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

FYN antibody

Immunofluorescence staining of FYN in murine transformed fibroblasts using FYN monoclonal antibody, clone FYN - 01 ( Cat # MAB0947 ; red ) . Actin cytoskeleton was decorated by phalloidin ( green ) and cell nuclei stained with DAPI ( blue ) . Mouse IgG FYN-01 Hu, Ms ICC/IF, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

FYN antibody

Human HEK293T; Host:Rabbit. Target Name:FYN. Sample Tissue:293T. Antibody Dilution: 1.0ug/ml. FYN is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells.; FYN antibody - N-terminal region (ARP55567_P050) in Human HEK293T cells using Western Blot Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

FYN antibody

Immunofluorescence: Fyn Ab (FYN-01) [NB500-517] - Fig. 4. IF staining of Fyn in murine transformed fibroblasts using anti-Fyn (FYN-01; red). Actin cytoskeleton was decorated by phalloidin (green) and cell nuclei stained with DAPI (blue). Mouse IgG FYN-01 Aff - Purified Hu, Ms ICC/IF, IP, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

FYN (N-term) antibody

TA302725 staining 0.2µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
20 µg / €200.00
  Acris Antibodies GmbH

FYN (N-term) antibody

TA302725 staining 0.2µg/ml) of Jurkat lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

FYN (N-term) antibody

Western blot analysis of FYN Antibody (N-term) (Cat. #TA324974) in Hela cell line lysates (35ug/lane). FYN (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

FYN antibody

Western blot analysis of Fyn expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FYN antibody

Western blot analysis of extracts from HUVEC cells, MCF-7 cells and 293 cells, using Fyn (Ab-530) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FYN antibody

WB Suggested Anti-FYN Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: COLO205 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

FYN antibody

Western blot detection of Fyn in Hela,3T3,C6,COS7,CEM,Ramos and Jurkat cell lysates using Fyn mouse mAb (1:500 diluted).Predicted band size:59KDa.Observed band size:59KDa. Mouse IgG2b 4B8-E7-A8 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

FYN antibody

Figure 1. AM05300PU-N Fyn antibody staining of Formalin Fixed, Paraffin Embedded Human lymphoma tissue. Mouse IgG1 1S Purified Hu, Ms, Rt P, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

FYN antibody

Western blot analysis using FYN mouse mAb against NIH/3T3 (1) and Hela (2) cell lysate. Mouse IgG1 2H8 Ascites Hu, Ms E, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

FYN (7-176) antibody

Formalin-Fixed, Paraffin- Embedded Human Brain Cerebellum stained with Fyn Antibody Cat.-No AM33106PU (Clone FYN-59) at 15 µg/ml after heat-induced antigen retrieval. Mouse IgG FYN-59 Aff - Purified Hu, Ms IP, P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

FYN (7-176) antibody

Formalin-Fixed, Paraffin- Embedded Human Brain Cerebellum stained with Fyn Antibody Cat.-No AM33106PU (Clone FYN-59) at 15 µg/ml after heat-induced antigen retrieval. Mouse IgG FYN-59 Aff - Purified Hu, Ms IP, P, WB
25 µg / €220.00
  Acris Antibodies GmbH

FYN (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

FYN pTyr530 antibody

Immunohistochemistry analysis of Fyn antibody (Cat.-No.: AP20942PU-N) pTyr530 in paraffin-embedded Human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

FYN antibody

Western blot (WB) analysis of Fyn antibody (Cat.-No.: AP21058PU-N) in extracts from MCF-7 cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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