GAB3 antibody

Principal name

GAB3 antibody

Alternative names for GAB3 antibody

GRB2-associated-binding protein 3, Growth factor receptor bound protein 2-associated protein 3, GRB2-associated binder 3

SwissProt ID

Q8BSM5 (Mouse), Q8WWW8 (Human)

Gene ID

139716 (GAB3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of GAB3 antibody

The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
Seiffert, M., et al. Mol. Cell. Biol. 23(7):2415-2424(2003)

4 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GAB3 (N-term) antibody

Western blot analysis of GAB3 Antibody (N-term) Cat.-No AP51753PU-N in human placenta tissue lysates (35ug/lane). This demonstrates the GAB3 antibody detected the GAB3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GAB3 antibody

Immunohistochemistry-Paraffin: GAB3 Antibody [NBP1-86111] - Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GAB3

GAB3 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GAB3 overexpression lysate

GAB3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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