GABRA1 antibody

Principal name

GABRA1 antibody

Alternative names for GABRA1 antibody

GABRA-1, GABA A receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-1

SwissProt ID

P08219 (Bovin), P14867 (Human), P19150 (Chick), P62812 (Mouse), P62813 (Rat)

Gene ID

2554 (GABRA1), 29705 (Gabra1), 14394

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey), Ze (Zebrafish), African clawed frog, Por (Porcine), Rb (Rabbit), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Immunoprecipitation (IP)

Background of GABRA1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (3). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (4).

General readings

Peran,M., et al., (2004) Neurosci. Lett. 364 (2), 67-70

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRA1 antibody

  Rabbit Anti-GABAA Receptor a 1 Antibody  
Western blot of mouse forebrain lysates from wild type (Control) and α1-knockout (α1-K/O) animals showing specific immunolabeling of the ~51k α1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from α1-knockout animals. Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt Dot, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA1 (N-term) antibody

  Rabbit Anti-GABAA Receptor a 1, N-Terminus Antibody  
Western blot of mouse forebrain lysates from Wild Type (Control) and α1-knockout (α1-K/O) animals showing specific immunolabeling of the ~51k α1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from α1-knockout animals. Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA1 (327-450) antibody

  Mouse Monoclonal Anti-GABA(A) Receptor alpha1 Antibody  
Western blot analysis of GAB(A)R, Delta in a human cell line mix using a 1:1000 dilution of the antibody Mouse IgG2a S95-35 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRA1 antibody

  Rabbit Polyclonal Anti-GABA (A) alpha1 Receptor (extracellular)  
Western blot analysis of rat brain lysates: 1. Anti-GABA(A) a1 Receptor  (extracellular) antibody, (1:1000). 2. Anti-GABA(A) a1 Receptor (extracellular) antibody preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GABRA1 antibody

  Rabbit Polyclonal Anti-GABRA1 Antibody  
WB Suggested Anti-GABRA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRA1 antibody

  Rabbit Polyclonal Anti-GABRA1 Antibody  
WB Suggested Anti-GABRA1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRA1 antibody

  Rabbit Polyclonal Anti-GABRA1 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: LoVo cells, Primary antibody: (GABRA1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA1 antibody

adult rat brain immunohistochemistry (with antigen retrieval via pepsin pretreatment) Mouse IgG2a N95/35 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

GABRA1 antibody

adult rat brain immunohistochemistry (with antigen retrieval via pepsin pretreatment) Mouse IgG2a N95/35 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

GABRA1 antibody

GABRA1 Rabbit IgG Purified Bov, Can, Chk, Hu, Mky, Ms, Rt WB
0.1 ml / €500.00
  Acris Antibodies GmbH

GABRA1 (N-term) antibody

GABRA1 Rabbit IgG Purified Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRA1 antibody

Immunohistochemistry (IHC) analyzes of GABAA Ralpha1 antibody (Cat.-No.: AP20674PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

GABRA1 (alpha-1) antibody

Brain stained in IHC-P with GABRA1 antibody Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GABRA1 (N-term) antibody

GABRA1 Rabbit IgG Serum Hu, Rt WB
0.1 ml / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

GABRA1 - human gene knockout kit via CRISPR

GABRA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GABRA1 - human gene knockout kit via CRISPR

GABRA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GABRA1 - human gene knockout kit via CRISPR

GABRA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GABRA1 - human gene knockout kit via CRISPR

GABRA1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabra1 - mouse gene knockout kit via CRISPR

Gabra1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gabra1 - mouse gene knockout kit via CRISPR

Gabra1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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