GABRA3 antibody

Principal name

GABRA3 antibody

Alternative names for GABRA3 antibody

GABRA-3, GABA A Receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-3

SwissProt ID

P10064 (Bovin), P20236 (Rat), P26049 (Mouse), P34903 (Human)

Gene ID

2556 (GABRA3), 24947 (Gabra3), 14396

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Bt (Bat), Chk (Chicken), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), Tr (Turkey), Bear, Ze (Zebrafish), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of GABRA3 antibody

GABA (?-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory syptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory syptic transmission. Functiol GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site. Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsyptic inhibitions: presyptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsyptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to syptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation.

General readings

Chou,K.C. et al., (2004) Biochem. Biophys. Res. Commun. 316 (3), 636-642

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