GABRA4 antibody

Principal name

GABRA4 antibody

Alternative names for GABRA4 antibody

GABRA-4, GABAA Receptor alpha-4, Gamma-Aminobutyric Acid Receptor subunit Alpha-4

SwissProt ID

P20237 (Bovin), P28471 (Rat), P48169 (Human), Q9D6F4 (Mouse)

Gene ID

140675 (Gabra4), 2557 (GABRA4), 14397

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), Eq (Equine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of GABRA4 antibody

GABA (?-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.The GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of sigl-receiving neurons by interacting with the GABAA receptor on these cells. Binding of GABA to its GABAA receptor results in conformatiol changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.GABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: a, Ã?, ?, d, e, p, ?, and ?. Six a subunit isoforms have been found to exist in mammals (a1-a6). In most cases, tive GABAA receptors consist of 2a, 2Ã?, and 1? subunits. The a subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.Each subtype has a unique regiol expression in the brain, and individual neurons often express multiple subtypes. For example, the a4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain.

General readings

Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA.
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
Am J Hum Genet. 2005 Sep;77(3):377-88.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRA4 antibody

  Rabbit Anti-GABAA Receptor a 4, Antibody  
Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k α4-subunit of the GABAA-R. Rabbit IgG Aff - Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 (N-term) antibody

  Rabbit Anti-GABAA Receptor a 4, N-Terminus Antibody  
Western blot of 10 μg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k α4-subunit of the GABAA -R. Rabbit IgG Aff - Purified Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

  Goat Anti-GABRA4 Antibody  
TA305622 (0.1ug/ml) staining of Human Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

  Rabbit polyclonal anti-GABRA4 antibody  
Western blot analysis of extracts from HepG2 cells, using GABRA4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

  Rabbit Polyclonal Anti-GABA(A) alpha4 (extracellular)  
Western blot analysis of rat brain lysate (lanes 1 and 4), mouse brain membrane (lanes 2 and 5) and CCF-STGI cell line lysate (lanes 3 and 6): 1-3. Anti-GABA(A) a4 Receptor (extracellular) antibody, (1:200). 4-6. Anti-GABA(A) a4  Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GABRA4 antibody

  Rabbit Polyclonal Anti-GABRA4 Antibody  
WB Suggested Anti-GABRA4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:2500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Eq, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRA4 (C-term) antibody

GABRA4 Rabbit IgG Purified Bov, Hu, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRA4 (349-361) antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with GABRA4 antibody AP22583PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bov, Elephant, Hu, Mky, Op, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

GABRA4 antibody

GABA A Receptor alpha 4 (dilution: 2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €420.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Gabra4 - mouse gene knockout kit via CRISPR

Gabra4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gabra4 - mouse gene knockout kit via CRISPR

Gabra4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabra4 - mouse gene knockout kit via CRISPR

Gabra4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabra4 - mouse gene knockout kit via CRISPR

Gabra4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gabra4 (GFP-tagged) - Mouse gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gabra4 (GFP-tagged) - Mouse gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gabra4 (Myc-DDK-tagged) - Mouse gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gabra4 (Myc-DDK-tagged) - Mouse gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gabra4 (GFP-tagged ORF) - Rat gamma-aminobutyric acid (GABA) A receptor, alpha 4 (Gabra4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gabra4 (GFP-tagged ORF) - Rat gamma-aminobutyric acid (GABA) A receptor, alpha 4 (Gabra4), 200 uL, >10^7 TU/mL  
200 µl / €1,190.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gabra4 (Myc-DDK-tagged ORF) - Rat gamma-aminobutyric acid (GABA) A receptor, alpha 4 (Gabra4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gabra4 (Myc-DDK-tagged ORF) - Rat gamma-aminobutyric acid (GABA) A receptor, alpha 4 (Gabra4), 200 uL, >10^7 TU/mL  
200 µl / €1,064.00
  OriGene Technologies, Inc.

17 Item(s)

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