GABRA4 antibody

Principal name

GABRA4 antibody

Alternative names for GABRA4 antibody

GABRA-4, GABAA Receptor alpha-4, Gamma-Aminobutyric Acid Receptor subunit Alpha-4

SwissProt ID

P20237 (Bovin), P28471 (Rat), P48169 (Human), Q9D6F4 (Mouse)

Gene ID

140675 (Gabra4), 2557 (GABRA4)

Available reactivities

Rt (Rat), Bov (Bovine), Hu (Human), Ms (Mouse), Mky (Monkey), Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C)

Background of GABRA4 antibody

GABA (?-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake, and metabolism all occur in the nervous system.The GABA transmitter interacts with two major types of receptors: ionotropic GABAA receptors (GABAAR) and metabotropic receptors (GABABR). GABAARs belong to the ligand-gated ion channel superfamily. GABA inhibits the activity of sigl-receiving neurons by interacting with the GABAA receptor on these cells. Binding of GABA to its GABAA receptor results in conformatiol changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.GABAARs are heteropentamers, in which all five subunits contribute to the pore formation. To date, eight subunit isoforms have been cloned: a, Ã?, ?, d, e, p, ?, and ?. Six a subunit isoforms have been found to exist in mammals (a1-a6). In most cases, tive GABAA receptors consist of 2a, 2Ã?, and 1? subunits. The a subunit is the most common and is expressed ubiquitously. It determines the affinity of GABAARs for allosteric ligands.Each subtype has a unique regiol expression in the brain, and individual neurons often express multiple subtypes. For example, the a4 subunit is detected in the hippocampus, cortex, olfactory bulb and in the basal forebrain.

General readings

Ma DQ, Whitehead PL, Menold MM, Martin ER, Ashley-Koch AE, Mei H, Ritchie MD, Delong GR, Abramson RK, Wright HH, Cuccaro ML, Hussman JP, Gilbert JR, Pericak-Vance MA.
Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.
Am J Hum Genet. 2005 Sep;77(3):377-88.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRA4 antibody

Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~64k α4-subunit of the GABAA-R. Rabbit IgG Aff - Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 (N-term) antibody

Western blot of 10 μg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k α4-subunit of the GABAA -R. Rabbit IgG Aff - Purified Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

TA305622 (0.1ug/ml) staining of Human Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

Western blot analysis of extracts from HepG2 cells, using GABRA4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRA4 antibody

Western blot analysis of rat brain lysate (lanes 1 and 4), mouse brain membrane (lanes 2 and 5) and CCF-STGI cell line lysate (lanes 3 and 6): 1-3. Anti-GABA(A) a4 Receptor (extracellular) antibody, (1:200). 4-6. Anti-GABA(A) a4  Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GABRA4 antibody

WB Suggested Anti-GABRA4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:2500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Eq, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRA4 (C-term) antibody

GABRA4 Rabbit IgG Purified Bov, Hu, Ms, Rt WB
0.1 ml / €510.00
  Acris Antibodies GmbH

GABRA4 (349-361) antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with GABRA4 antibody AP22583PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bov, Elephant, Hu, Mky, Op, Prim, Rb E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

GABRA4 antibody

GABRA4 Mouse IgG2a 6A12 Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

GABRA4 antibody

Western blot of 10 µg of rat brain hippocampus (Hipp) lysate showing immunolabeling of the ~64k a4 subunit of the Gabra4. Rabbit Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

GABRA4 antibody

GABRA4 Rabbit Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

GABRA4 antibody

GABRA4 polyclonal antibody ( Cat # PAB11468 ) ( 0.1 µg/ml ) staining of human frontal cortex lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

GABRA4 antibody

Human ACHN; WB Suggested Anti-GABRA4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:2500. Positive Control: ACHN cell lysate; GABRA4 antibody - N-terminal region (ARP34982_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Bov, Hu WB
50 µg / €350.00
  AVIVA Systems Biology

GABRA4 antibody

Western blot analysis of GABRA4 expression in MCF7 (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

Western blot analysis of GABRA4 expression in MCF7 (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

Western blot analysis of GABRA4 expression in MCF7 (A); SP2/0 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

Western blot analysis of GABRA4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

Western blot analysis of GABRA4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

Western blot analysis of GABRA4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

GABRA4 antibody

GABA A Receptor alpha 4 (dilution: 2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu E, P, WB
0.1 mg / €400.00
  Neuromics Antibodies

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