GABRB3 antibody

Principal name

GABRB3 antibody

Alternative names for GABRB3 antibody

GABRB-3, GABA A receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit beta-3

SwissProt ID

P19019 (Chick), P28472 (Human), P63079 (Rat), P63080 (Mouse)

Gene ID

2562 (GABRB3), 24922 (Gabrb3), 14402

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), Eq (Equine), Fe (Feline), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Tr (Turkey), L (Lizard), Bear, Xen (Xenopus), GP (Guinea Pig)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of GABRB3 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.
There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2).
The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (3). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (4).

General readings

Tanaka M, Olsen RW, Medina MT, Schwartz E, Alonso ME, Duron RM, Castro-Ortega R, Martinez-Juarez IE, Pascual-Castroviejo I, Machado-Salas J, Silva R, Bailey JN, Bai D, Ochoa A, Jara-Prado A, Pineda G, Macdonald RL, Delgado-Escueta AV. Hyperglycosylation and reduced GABA currents of mutated GABRB3 polypeptide in remitting childhood absence epilepsy. Am. J. Hum. Genet. 2008 Jun 82 (6): 1249-61.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRB3 antibody

Western blot of 5-7 ug of mouse cerebellum lysates from wild type (Control) and β3 knockout (β3  K/O) animals showing specific immunolabeling of  the ~53k β3-subunit of the GABAA-R in the wild type but not in the β3 K/O animals. Rabbit IgG Aff - Purified Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRB3 antibody

immunofluorescence of cultured hippocampal neurons with N87/25 (red) and GABA-A-R-Gamma2 rabbit polyclonal (green). Images courtesy of Angel de Blas (University of Connecticut). Mouse IgG1 N87/25 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

GABRB3 antibody

immunofluorescence of cultured hippocampal neurons with N87/25 (red) and GABA-A-R-Gamma2 rabbit polyclonal (green). Images courtesy of Angel de Blas (University of Connecticut). Mouse IgG1 N87/25 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

GABRB3 antibody

Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k GABAA ß3 protein phosphorylated at Ser408/409 (control). Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRB3 (370-433) antibody

Western blot analysis of GABA(A)R Beta3 in rat brain membrane lysates using a 1:1000 dilution of the antibody Mouse IgG1 S87-25 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRB3 antibody

GABRB3 Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRB3 antibody

GABRB3 Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRB3 antibody

WB Suggested Anti-GABRB3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRB3 antibody

Anti-GABRB3 (AP10064PU-N)(2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

GABRB3 (400-411) antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with GABRB3 antibody AP22582PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Can, Elephant, Eq, Fe, Hst, Hu, L, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

GABRB3 pSer408/409 antibody

Western blot of Rat hippocampal lysate showing specific immunolabeling of the ~53k GABAAB3 protein phosphorylated at Serine408/409 (Control). Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt, Xen, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

GABRB3 antibody

GABRB3 Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GABRB3 antibody

GABRB3 Rabbit Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

GABRB3 antibody

GABRB3 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

GABRB3 antibody

Human Liver; WB Suggested Anti-GABRB3 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Liver; GABRB3 antibody - middle region (ARP35339_P050) in Human Liver cells using Western Blot Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

GABRB3 antibody

GABA A Receptor beta 3 (dilution: 2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Hu
0.1 mg / €420.00
  Neuromics Antibodies

GABRB3 (370-433) antibody

GABA A Receptor beta 3 staining of adult rat hippocampus. Mouse IgG1 Liquid Ms, Rt C, ICC/IF, WB
0.1 ml / €440.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Gabrb3 - mouse gene knockout kit via CRISPR

Gabrb3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gabrb3 - mouse gene knockout kit via CRISPR

Gabrb3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabrb3 - mouse gene knockout kit via CRISPR

Gabrb3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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