GABRG2 antibody

Principal name

GABRG2 antibody

Alternative names for GABRG2 antibody

GABRG-2, GABA A Receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-2

SwissProt ID

P18507 (Human), P18508 (Rat), P21548 (Chick), P22300 (Bovin), P22723 (Mouse)

Gene ID

29709 (Gabrg2), 2566 (GABRG2), 14406

Available reactivities

Chk (Chicken), Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P)

Background of GABRG2 antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC-epsilon regulates the sensitivity of GABAA Alpha1/Beta2/Gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of Gamma2 (Qi et al., 2007)

General readings

Sancar,F. (2004) J. Biol. Chem. 279 (45), 47034-47039

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRG2 antibody

  Rabbit Anti-GABAA Receptor g2, Antibody  
Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~46k γ2-subunit of GABAA -R. Rabbit IgG Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRG2 (400-410) antibody

AP20117PU-N GABRG2 antibody staining of Mouse Brain lysate at 2 µg/ml (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GABRG2 antibody

  Rabbit Anti-GABAA Receptor g2 Antibody  
Western blot of rat spinal cord showing specific immunolabeling of the ~48k a1- and a2-subunits of the glycine receptor. The labeling was absent from a rat hippocampal (hipp) lysate as the glycine receptor is not expressed in the hippocampus. Rabbit IgG Serum Chk, Hu, Ms, non-Human Primates, Rt, Ze C, WB
50 µl / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Anti-GABAA Receptor, g 2 (Ser327) Antibody (Phospho-Specific)  
Western blot of rat cortex showing specific immunolabeling of the ~45k GABA  γ A2 protein phosphorylated at Ser327 (control). Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Polyclonal Anti-GABA (A) gamma2 Receptor (extracellular)  
Western blot analysis of rat brain membranes: 1. Anti-GABA(A) ?2 Receptor (extracellular) antibody, (1:200). 2. Anti-GABA(A) ?2 Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Polyclonal Anti-GABRG2 Antibody  
WB Suggested Anti-GABRG2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human brain Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Polyclonal Anti-GABRG2 Antibody  
WB Suggested Anti-GABRG2 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Polyclonal Anti-GABRG2 Antibody  
Host: Rabbit; Target Name: GABRG2; Sample Tissue: Esophagus Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

  Rabbit Polyclonal Anti-GABRG2 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Mouse brain tissue, human fetal brain tissue, Primary antibody: (GABRG2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GABRG2 antibody

GABRG2 Rabbit IgG Serum Chk, Hu, Mky, Ms, Rt, Ze WB
50 µl / €510.00
  Acris Antibodies GmbH

GABRG2 antibody

GABRG2 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GABRG2 - human gene knockout kit via CRISPR

GABRG2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GABRG2 - human gene knockout kit via CRISPR

GABRG2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GABRG2 - human gene knockout kit via CRISPR

GABRG2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GABRG2 - human gene knockout kit via CRISPR

GABRG2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabrg2 - mouse gene knockout kit via CRISPR

Gabrg2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gabrg2 - mouse gene knockout kit via CRISPR

Gabrg2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabrg2 - mouse gene knockout kit via CRISPR

Gabrg2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gabrg2 - mouse gene knockout kit via CRISPR

Gabrg2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GABRG2 overexpression lysate

GABRG2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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