GABRR1 antibody

Principal name

GABRR1 antibody

Alternative names for GABRR1 antibody

GABA(A) receptor subunit rho-1, Gamma-aminobutyric acid receptor subunit rho-1, GABA(C) receptor

SwissProt ID

P24046 (Human), P50572 (Rat), P56475 (Mouse)

Gene ID

2569 (GABRR1), 29694 (Gabrr1), 14408

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of GABRR1 antibody

?-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter. It is involved in roughly 40% of the inhibitory sypses.GABA acts through two receptors, GABA(A) and GABA(B). To date, nineteen different GABA(A) subunits have been identified and divided in eight subunits: a (1-6), Ã? (1-3), ? (1-3), d, e, ? (1-3), ? and p. For some of the subunits, altertive splicing further increases the number of existing receptor types. They all have extracellular N- and C-termini and four transmembrane domains.Three r subunits have been detected: GABA(A) ?1, GABA(A) ?2 and GABA(A) ?3. Like all GABA(A) receptors the ? subunits also assemble into a pentameric structure forming a Cl- channel. However, in contrast to all other GABA(A) subunits they mostly form homomeric entities. The GABA(A) ? subunits display different pharmacological characteristics and were therefore once referred to GABA(C) receptors. GABA(A) and GABA(B) respectively respond to bicuculline and baclofen, whereas ? subunits are insensitive to either drug. In addition, ? subunits also display different electrophysiological properties, and are significantly more sensitive to GABA.r subunits are highly expressed in the reti and it was believed that they are only expressed in that area. They are however, also expressed in central and peripheral nervous systems, as well as in the gastrointestil and cardiovascular systems.

General readings

Jansen,M., (2008) J. Gen. Physiol. 131 (2), 137-146

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GABRR1 antibody

  Anti-GABRR1 Rabbit Polyclonal Antibody  
Western blot analysis of Mouse liver tissue using TA323067(GABRR1 Antibody) at dilution 1/200 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

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