GADD45B antibody

Principal name

GADD45B antibody

Alternative names for GADD45B antibody

MYD118, Growth arrest and DNA-damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118

SwissProt ID

O75293 (Human), P22339 (Mouse), Q5E9A5 (Bovin)

Gene ID

4616 (GADD45B)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), Flow Cytometry (F)

Background of GADD45B antibody

Growth-Arrest and DNA-damage inducible 45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in either cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. GADD proteins acts as stress sensors and are mediated by physical interaction with cellular proteins such as PCNA, p21, cdc2/cyclinB1, p38 and JNK stress response kinase, that are implicated in cell cycle regulation and stress related responses. There are two isoforms of GADD45 known (GADD45a and GADD45b), myeloid enriched bone marrow cells from mouse deficient in GADD45a and GADD45b are more susceptible to apoptosis induced chemically or by UV radiation than wild type cells (1). These data suggest that GADD45 proteins are anti-apoptotic and increase the survival of hematopoietic cells following UV irradiation. The GADD45b deficient mouse also exhibit deficiencies in neuronal activity induced proliferation of neuronal progenitors and dendritic growth of new born neurons in adult hippocampus. GADD45b is required for activity-induced DNA demethylation of specific promotors and expression of corresponding genes critical for adult neurogenesis brain derived neurotrophic factors and fibroblast growth factor (2).
Electro-convulsive treatment ECT) of adult mice cuases a sustained up-regulation of hippocampal neurogenesis without any significant cell damage. ECT also up-regulated GADD45b, a known epigenetic regulator (2). The neuroprotective effect of GADD45b has been shown in retinal ganglion cells (RGC), GADD45b is up-regulated in RGCs in response to oxidative stress, aging and increasing ocular pressure. Using GADD45b SiRNA, the RGCs are protected from dying against different neuronal injury including oxidative stress, TNF alfa cytotoxicity and glutamate excitotoxicity in vitro, suggesting GADD45b is a component of an intrinsic neuroprotective mechanism in RGC in retina and perhaps in CNS (3). GADD45b is a neuronal activity-induced immediate early gene in mature hippocampal neurons (2). GADD45b also promotes hepatocyte survival during liver regeneration in mice by modulating the activity of JNK signaling, suggestingthat GADD45b may be a potential therapeutic target in liver disease (4). GADD45b is a 160 amino acid (20kDa) protein.

General readings

Tornatore,L., (2008) J. Mol. Biol. 378 (1), 97-111

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GADD45B antibody

Human Prostate Cancer; Product Page for GADD45B antibody - middle region (ARP48346_P050). . . Sample Type :. Human Prostate Cancer. . Primary Antibody Dilution :. 2ug/mL . Color/Signal Descriptions:. GADD45B (DAB; brown), nuclei (hematoxylin; blue) . Gene Name:. GADD45B .; GADD45B antibody - middle region (ARP48346_P050) in Human Prostate Cancer cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

GADD45B Control Peptide

GADD45B Aff - Purified IP, WB
0.25 mg / €250.00
  Acris Antibodies GmbH

GADD45B (C-term) antibody

GADD45B Rabbit Aff - Purified Chimp, Hu, Mky, Ms, Rt IP, WB
0.2 ml / €420.00
  Acris Antibodies GmbH

GADD45B antibody

GADD45B Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

GADD45B antibody

Western blot analysis of GADD45 beta expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

GADD45B antibody

Western blot analysis of GADD45 beta expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

GADD45B antibody

Western blot analysis of GADD45 beta expression in MCF7 (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

GADD45B antibody

Western Blot: MYD118 Antibody [NBP1-58997] - This Anti-GADD45B antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.25ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

GADD45B antibody

Immunohistochemistry-Paraffin: MYD118 Antibody [NBP1-87990] Immunohistochemical staining of human rectum shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GADD45B

GADD45B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

GADD45B

GADD45B Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

GADD45B (1-160)

GADD45B Human Purified > 95 % by SDS-PAGE E. coli
0.5 mg / €540.00
  Acris Antibodies GmbH

GADD45B (1-160)

GADD45B Human Purified > 95 % by SDS-PAGE E. coli
0.1 mg / €230.00
  Acris Antibodies GmbH

GADD45B

GADD45B Human
0.1 mg / €330.00
  Abnova Taiwan Corp.

GADD45B

SDS-Page: MYD118 Protein [NBC1-18436] - GADD45B, 17.8 kDa (160 aa), confirmed by MALDI-TOF with a purity of 95% by SDS - PAGE Protein
0.1 mg / €310.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

GADD45B overexpression lysate

GADD45B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

16 Item(s)

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