Galactocerebrosidase antibody

Principal name

Galactocerebrosidase antibody

Alternative names for Galactocerebrosidase antibody

GALCERase, GALC, Galactosylceramidase, Galactosylceramide beta-galactosidase, Galactocerebroside beta-galactosidase

SwissProt ID

P54803 (Human), P54804 (Canfa), P54818 (Mouse)

Gene ID

14420 (Galc), 2581 (GALC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), African clawed frog, Ze (Zebrafish), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Galactocerebrosidase antibody

Galactosylceramidase hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. It is an enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. It shows highest level of activity in testes compared to brain, kidney, placenta and liver. It can also be found in urine. Defects in Galactosylceramidase are the cause of globoid cell leukodystrophy (GLD); also known as Krabbe disease. This autosomal recessive disorder results in the insufficient catabolism of several galactolipids that are important in the production of normal myelin. Clinically, the most frequent form is the infantile form. Most patients (90%) present before six months of age with irritability, spasticity, arrest of motor and mental development, and bouts of temperature elevation without infection. This is followed by myoclonic jerks of arms and legs, oposthotonus, hypertonic fits, and mental regression, which progresses to a severe decerebrate condition with no voluntary movements and death from respiratory infections or cerebral hyperpyrexia before 2 years of age. However, a significant number of cases with later onset, presenting with unexplained blindness, weakness and/or progressive motor, and sensory neuropathy that can progress to severe mental incapacity and death, have been identified.

General readings

Formichi,P., (2007) J. Cell. Physiol. 212 (3), 737-743

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Galactocerebrosidase antibody

WB Suggested Anti-GALC Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Galactocerebrosidase antibody

Western Blot analysis of GALC expression in transfected 293T cell line (H00002581-T02) by GALC MaxPab polyclonal antibody.

Lane 1: GALC transfected lysate(75.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Galactocerebrosidase antibody

Galactocerebrosidase Mouse IgG2a 2D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Galactocerebrosidase antibody

Human Jurkat; WB Suggested Anti-GALC Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; GALC antibody - middle region (ARP44847_P050) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Galactocerebrosidase antibody

Western Blot: GALC Antibody [NBP1-62280] - This Anti-GALC antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Galactocerebrosidase

Galactocerebrosidase Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Galactocerebrosidase

Galactocerebrosidase Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

per page
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