GALE antibody

Principal name

GALE antibody

Alternative names for GALE antibody

Galactowaldenase, UDP-glucose 4-epimerase, UDP-galactose 4-epimerase

SwissProt ID

P09147 (Ecoli), P18645 (Rat), Q14376 (Human), Q8R059 (Mouse), Q9W0P5 (Drome)

Gene ID

2582 (GALE)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), African clawed frog, Can (Canine), Mky (Monkey), Por (Porcine), Rb (Rabbit), Eq (Equine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of GALE antibody

GALE is an UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (\'peripheral\' form) to severe (\'generalized\' form). This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild (\'peripheral\' form) to severe (\'generalized\' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

General readings

Holden HM., et al. (2003) J Biol Chem. 278(45):43885-8.
Timson DJ., et al. (2005) FEBS J. 272(23):6170-7.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GALE antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GALE mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502146) Mouse IgG1 OTI1C4 Purified Can, Hu, Mky, Rt P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

GALE antibody

WB Suggested Anti-GALE Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GALE antibody

WB Suggested Anti-GALE Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GALE (Center) antibody

Western blot analysis of GALE Antibody (Center) (AP17410PU-N) in A375 cell line lysates (35 µg/lane). GALE (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GALE antibody

GALE Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

GALE antibody

GALE MaxPab polyclonal antibody. Western Blot analysis of GALE expression in human colon. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

GALE antibody

GALE MaxPab polyclonal antibody. Western Blot analysis of GALE expression in human colon. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

GALE antibody

GALE Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

GALE antibody

GALE Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

GALE antibody

Human Liver; WB Suggested Anti-GALE Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Liver; GALE antibody - N-terminal region (ARP54393_P050) in Human Liver cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

GALE antibody

GALE Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GALE (transcript variant 1)

GALE Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

GALE (transcript variant 2)

GALE Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

GALE (transcript variant 3)

GALE Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

GALE (transcript variant 1)

GALE Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €399.00
  OriGene Technologies, Inc.

GALE (1-348, His-tag)

GALE Human Purified > 95 % by SDS – PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

GALE (1-348, His-tag)

GALE Human Purified > 95 % by SDS – PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

GALE

GALE Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GALE

GALE Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

GALE (Human) IP-WB Antibody Pair

GALE (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

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