Galectin-3 antibody

Principal name

Galectin-3 antibody

Alternative names for Galectin-3 antibody

Mac-2, Lgals3, GAL3, GALBP, CBP35, L-31, Galactose-specific lectin 3, IgE-binding protein, 35 kDa lectin, Carbohydrate-binding protein 35, Laminin-binding protein, Lectin L-29, L-34 galactoside-binding lectin

SwissProt ID

P08699 (Rat), P16110 (Mouse), P17931 (Human), P38486, P47845 (Rabit)

Gene ID

3958 (LGALS3), 16854 (Lgals3), 404021

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Rat, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Functional assay (FN), Immunoprecipitation (IP), Luminex (LMNX)

Background of Galectin-3 antibody

Galectin-3 is a member of the galectin family. The protein is composed of three domains: a small amino-terminal domain, a carboxyl-terminal carbohydrate recognition domain (CRD) and amino-terminal domain containing repeating elements. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. The expression is also affected by neoplastic transformation: up-regulated in certain types of lymphomas and thyroid carcinoma, while down-regulated in other types of malignancies, such as colon, breast, ovarian and uterine carcinomas.
Galectin-3 has been shown to function through both intracellular and extracellular actions. Related to its intracellular functions, galectin-3 has been identified as a component of heterogeneous nuclear ribonuclear protein (hnRNP), a factor in pre-mRNA splicing, and has been found to control cell cycle and prevent T cell apoptosis. On the other hand, this protein has also been demonstrated to function as extracellular molecule in activating various types of cells, including monocytes/macrophages, mast cells, neutrophils and lymphocytes. Galectin-3 has been shown to mediate cell-cell and cell-extracellular matrix interactions.

General readings

1. Ma F  et al. The requirement of CD8+ T cells to initiate and augment acute cardiac inflammatory response to high blood pressure. J Immunol 192:3365-73 (2014). IHC-P,ICC/IF ; Mouse .PubMed: 24600037
2. Lee YJ  et al. Spatial and temporal expression, and statin responsiveness of galectin-1 and galectin-3 in murine atherosclerosis. Korean Circ J 43:223-30 (2013). IHC-FoFr ; Mouse .PubMed: 23682281
3. Reticker-Flynn NE  et al. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nat Commun 3:1122 (2012).WB .PubMed: 23047680
4. Doe JA  et al. Transgenic overexpression of the a7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A. J Cell Sci 124:2287-97 (2011). WB, IHC-Fr ; Mouse .PubMed: 21652631
5. Checinska A  et al. Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells. J Proteomics 72:575-85 (2009).PubMed: 19118655

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Galectin-3 antibody

Galectin-3 Rat IgG2a M3/38 Biotin Ms C, E, F, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Galectin-3 antibody

Cell Source: Thioglycollate-elicited peritoneal exudate
Percentage of cells stained above control: 48.0% Rat IgG2a M3/38 Purified Ms C, E, F, ICC/IF, P, WB
0.1 mg / €310.00
  Acris Antibodies GmbH

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-LGALS3 mouse monoclonal antibody. (UM500104, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB157 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-LGALS3 mouse monoclonal antibody. (UM500104, heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.0, 120C for 3min) Mouse IgG1 UMAB157 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-LGALS3 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800081)(1:200) Mouse IgG1 UMAB189 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil using anti-LGALS3 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.0) at 120C for 3 min, UM800081)(1:200) Mouse IgG1 UMAB189 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506397) Mouse IgG1 OTI1A2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunofluorescent staining of HeLa cells using anti-LGALS3 mouse monoclonal antibody (TA506398). Mouse IgG1 OTI1A4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506399) Mouse IgG1 OTI1G8 Purified Can, Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506400) Mouse IgG1 OTI1A3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-LGALS3 mouse monoclonal antibody (TA506401) at 1:150 dilution. Mouse IgG1 OTI1A1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA801621) Mouse IgG OTI1C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804567) Mouse IgG2b OTI2F1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804612) Mouse IgG1 OTI7G9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-LGALS3 Mouse monoclonal antibody. (TA804656; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI9C7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-LGALS3 Mouse monoclonal antibody. (TA804694; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG2a OTI6E1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-LGALS3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA804697) Mouse IgG1 OTI15E4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Galectin-3 antibody

Formalin-Fixed, Paraffin-Embedded Human Small Intestine stained with Galectin-3 Antibody Cat.-No AM50085PU-N Mouse IgG1 1G8 Purified Hu ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Galectin-3 antibody

Human Colon, Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Galectin-3 antibody

Immunofluorescence of purified MaxPab antibody to LGALS3 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

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