GAPVD1 / RAP6 antibody

Principal name

GAPVD1 / RAP6 antibody

Alternative names for GAPVD1 / RAP6 antibody

Rab5-activating protein 6, GAPex-5, KIAA1521, GAPEX5, GTPase-activating protein and VPS9 domain-containing protein 1

SwissProt ID

A2RV61 (Xenla), A5D794 (Bovin), Q14C86 (Human), Q14C86-6, Q3UYD5 (Mouse)

Gene ID

26130 (GAPVD1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of GAPVD1 / RAP6 antibody

GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.

General readings

Hunker,C.M., (2006) Biochem. Biophys. Res. Commun. 340 (3), 967-975

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GAPVD1 / RAP6 antibody

WB Suggested Anti-GAPVD1 Antibody Titration: 0.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

GAPVD1 / RAP6 antibody

GAPVD1 MaxPab polyclonal antibody. Western Blot analysis of GAPVD1 expression in human placenta. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

GAPVD1 / RAP6 antibody

Human Brain; GAPVD1 antibody - N-terminal region (ARP42451_P050) in Human Brain cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

GAPVD1 / RAP6 antibody

Western Blot and Immunoprecipitation: GAPex5 Antibody [NBP1-19156] -Whole cell lysate from HeLa cells. GAPex5 was also immunoprecipitated by rabbit anti-GAPex5 antibody NBP1-19157. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

GAPVD1 / RAP6 antibody

Western Blot: RAP6 Antibody [NBP1-53013] - This Anti-GAPVD1 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.25ug/ml. Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

GAPVD1 / RAP6 antibody

Immunohistochemistry-Paraffin: RAP6 Antibody [NBP1-85136] - Immunohistochemical staining of human duodenum shows strong granular positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

GAPVD1 / RAP6 antibody

Immunohistochemistry-Paraffin: RAP6 Antibody [NBP1-85137] - Immunohistochemical staining of human appendix shows moderate cytoplasmic positivity in glanular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GAPVD1 / RAP6

GAPVD1 / RAP6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GAPVD1 / RAP6

GAPVD1 / RAP6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GAPVD1 293T Cell Transient Overexpression Lysate(Denatured)

GAPVD1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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