GAPVD1 / RAP6 antibody

Principal name

GAPVD1 / RAP6 antibody

Alternative names for GAPVD1 / RAP6 antibody

Rab5-activating protein 6, GAPex-5, KIAA1521, GAPEX5, GTPase-activating protein and VPS9 domain-containing protein 1

SwissProt ID

A2RV61 (Xenla), A5D794 (Bovin), Q14C86 (Human), Q14C86-6, Q3UYD5 (Mouse)

Gene ID

26130 (GAPVD1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of GAPVD1 / RAP6 antibody

GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.

General readings

Hunker,C.M., (2006) Biochem. Biophys. Res. Commun. 340 (3), 967-975

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GAPVD1 / RAP6 antibody

  Rabbit Polyclonal Anti-GAPVD1 Antibody  
WB Suggested Anti-GAPVD1 Antibody Titration: 0.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

GAPVD1 - human gene knockout kit via CRISPR

GAPVD1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GAPVD1 - human gene knockout kit via CRISPR

GAPVD1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GAPVD1 - human gene knockout kit via CRISPR

GAPVD1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GAPVD1 - human gene knockout kit via CRISPR

GAPVD1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GAPVD1 (mGFP-tagged)-Human GTPase activating protein and VPS9 domains 1 (GAPVD1), 200 uL, >10^7 TU/mL

Lenti ORF particles, GAPVD1 (mGFP-tagged)-Human GTPase activating protein and VPS9 domains 1 (GAPVD1), 200 uL, >10^7 TU/mL  
200 µl / €2,530.00
  OriGene Technologies, Inc.

Lenti ORF particles, GAPVD1 (Myc-DDK-tagged)-Human GTPase activating protein and VPS9 domains 1 (GAPVD1), 200 uL, >10^7 TU/mL

Lenti ORF particles, GAPVD1 (Myc-DDK-tagged)-Human GTPase activating protein and VPS9 domains 1 (GAPVD1), 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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