Gastrin-releasing peptide receptor antibody
Principal name
Gastrin-releasing peptide receptor antibody
Alternative names for Gastrin-releasing peptide receptor antibody
GRP-R, GRPR, GRP-preferring bombesin receptor
Ncbi ID
9606, NP_005305, NP_005305.1, NP_032203.1, NM_008177, NM_012706, NM_005314
Available reactivities
Available hosts
Available applications
Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of Gastrin-releasing peptide receptor antibody
Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue). BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R. BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified. All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth. GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestil tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes. In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation. Filly, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies. Alomone labs is pleased to offer a highly specific antibody directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor. Anti-Bombesin Receptor 2 (extracellular) antibody (#ABR-002) can be used in western blot alysis, as well as immunocytochemical and immunohistochemical applications, and will recognize BB2 from human, rat, mouse, and dog samples.
General readings
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Chao, C., et al. J. Surg. Res. 156(1):26-31(2009)
Ananias, H.J., et al. Prostate 69(10):1101-1108(2009)
Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009)

















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- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA328635 | Gastrin-releasing peptide receptor antibody |
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Rabbit Polyclonal Anti-Bombesin Receptor 2 (extracellular) | |||||||
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Rabbit | Purified | Hu, Ms, Rt | WB |
0.2 ml /
€622.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA316872 | Gastrin-releasing peptide receptor (Extracell. Dom.) antibody |
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GRPR Rabbit Polyclonal (Extracellular Domain) Antibody | |||||||
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Rabbit | Aff - Purified | Bov, Bt, Can, Eq, Gorilla, Hst, Hu, Marmoset, Mky, Ms, Por, Rb, Rt | P, WB |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA316873 | Gastrin-releasing peptide receptor (Cytopl. Dom.) antibody |
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GRPR Rabbit Polyclonal (Cytoplasmic Domain) Antibody | |||||||
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Rabbit | Aff - Purified | Bov, Bt, Can, Chk, Eq, Hst, Hu, Marmoset, Mky, Ms, Por, Rb, Rt | ICC/IF, P |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA321704 | Gastrin-releasing peptide receptor antibody |
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Anti-GRPR Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA321705 | Gastrin-releasing peptide receptor antibody |
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Anti-GRPR Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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AP51959PU-N | Gastrin-releasing peptide receptor (Center) antibody |
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Rabbit | Ig | Aff - Purified | Hu | F, P, WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
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CRISPR
Catalog No. | Species | Donor Vector | |
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KN210362 | GRPR - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210362BN | GRPR - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210362LP | GRPR - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN210362RB | GRPR - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN307357 | Grpr - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN307357BN | Grpr - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN307357LP | Grpr - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN307357RB | Grpr - mouse gene knockout kit via CRISPR |
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Mouse | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC210362L2V | Lenti ORF particles, GRPR (mGFP-tagged) - Human gastrin-releasing peptide receptor (GRPR), 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC210362L1V | Lenti ORF particles, GRPR (Myc-DDK tagged) - Human gastrin-releasing peptide receptor (GRPR) , 200 uL, >10^7 TU/mL |
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200 µl /
€969.00
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OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
Catalog No. | ||
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MR224721L2V | Lenti ORF particles, Grpr (GFP-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||
MR224721L1V | Lenti ORF particles, Grpr (Myc-DDK-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL |
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200 µl /
€804.00
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OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
Catalog No. | ||
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RR201544L2V | Lenti ORF particles, Grpr (GFP-tagged ORF) - Rat gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL |
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200 µl /
€907.00
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OriGene Technologies, Inc. | ||