Gastrin-releasing peptide receptor antibody

Principal name

Gastrin-releasing peptide receptor antibody

Alternative names for Gastrin-releasing peptide receptor antibody

GRP-R, GRPR, GRP-preferring bombesin receptor

SwissProt ID

P21729 (Mouse), P30550 (Human), P52500 (Rat)

Gene ID

2925 (GRPR), 14829 (Grpr), 24938

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Marmoset, Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Gorilla, Chk (Chicken)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Gastrin-releasing peptide receptor antibody

Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue). BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R. BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified. All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth. GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestil tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes. In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation. Filly, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies. Alomone labs is pleased to offer a highly specific antibody directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor. Anti-Bombesin Receptor 2 (extracellular) antibody (#ABR-002) can be used in western blot alysis, as well as immunocytochemical and immunohistochemical applications, and will recognize BB2 from human, rat, mouse, and dog samples.

General readings

Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Chao, C., et al. J. Surg. Res. 156(1):26-31(2009)
Ananias, H.J., et al. Prostate 69(10):1101-1108(2009)
Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Gastrin-releasing peptide receptor antibody

  Rabbit Polyclonal Anti-Bombesin Receptor 2 (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-Bombesin Receptor 2 (extracellular) antibody, (1:500). 3, 4. Anti-Bombesin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Gastrin-releasing peptide receptor (Extracell. Dom.) antibody

  GRPR Rabbit Polyclonal (Extracellular Domain) Antibody  
Anti-GRPR antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Eq, Gorilla, Hst, Hu, Marmoset, Mky, Ms, Por, Rb, Rt P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

Gastrin-releasing peptide receptor (Cytopl. Dom.) antibody

  GRPR Rabbit Polyclonal (Cytoplasmic Domain) Antibody  
Anti-GRPR antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Chk, Eq, Hst, Hu, Marmoset, Mky, Ms, Por, Rb, Rt ICC/IF, P
50 µg / €400.00
  OriGene Technologies, Inc.

Gastrin-releasing peptide receptor antibody

  Anti-GRPR Rabbit Polyclonal Antibody  
Western blot analysis of Human hepatocellular carcinoma tissue and A549 cell using TA321704(GRPR Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gastrin-releasing peptide receptor antibody

  Anti-GRPR Rabbit Polyclonal Antibody  
Predicted band size: 43 kDa . Positive control: Mouse pancreas tissue and A549 cell lysate. Recommended dilution: 1/1000-2000. (Gel: 10%SDS-PAGE Lane1: Mouse pancreas tissue lysate Lane2: A549 cell lysate Lysates: 40 ug per lane Primary antibody: 1/600 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gastrin-releasing peptide receptor (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded brain tissue reacted with GRPR Antibody (Center) Cat.-No AP51959PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GRPR - human gene knockout kit via CRISPR

GRPR - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRPR - human gene knockout kit via CRISPR

GRPR - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRPR - human gene knockout kit via CRISPR

GRPR - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRPR - human gene knockout kit via CRISPR

GRPR - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grpr - mouse gene knockout kit via CRISPR

Grpr - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Grpr - mouse gene knockout kit via CRISPR

Grpr - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grpr - mouse gene knockout kit via CRISPR

Grpr - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grpr - mouse gene knockout kit via CRISPR

Grpr - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRPR (mGFP-tagged) - Human gastrin-releasing peptide receptor (GRPR), 200 uL, >10^7 TU/mL

Lenti ORF particles, GRPR (mGFP-tagged) - Human gastrin-releasing peptide receptor (GRPR), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRPR (Myc-DDK tagged) - Human gastrin-releasing peptide receptor (GRPR) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRPR (Myc-DDK tagged) - Human gastrin-releasing peptide receptor (GRPR) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grpr (GFP-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grpr (GFP-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grpr (Myc-DDK-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grpr (Myc-DDK-tagged) - Mouse gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grpr (GFP-tagged ORF) - Rat gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grpr (GFP-tagged ORF) - Rat gastrin releasing peptide receptor (Grpr), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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