Gastrin-releasing peptide receptor antibody

Principal name

Gastrin-releasing peptide receptor antibody

Alternative names for Gastrin-releasing peptide receptor antibody

GRP-R, GRPR, GRP-preferring bombesin receptor

SwissProt ID

P21729 (Mouse), P30550 (Human), P52500 (Rat)

Gene ID

2925 (GRPR), 14829 (Grpr), 24938

Available reactivities

Hu (Human), Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Marmoset, Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Gorilla, Chk (Chicken)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Gastrin-releasing peptide receptor antibody

Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue). BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R. BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified. All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth. GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestil tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes. In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation. Filly, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies. Alomone labs is pleased to offer a highly specific antibody directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor. Anti-Bombesin Receptor 2 (extracellular) antibody (#ABR-002) can be used in western blot alysis, as well as immunocytochemical and immunohistochemical applications, and will recognize BB2 from human, rat, mouse, and dog samples.

General readings

Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Chao, C., et al. J. Surg. Res. 156(1):26-31(2009)
Ananias, H.J., et al. Prostate 69(10):1101-1108(2009)
Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009)

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