GCS-alpha-2 / GUCY1A2 antibody

Principal name

GCS-alpha-2 / GUCY1A2 antibody

Alternative names for GCS-alpha-2 / GUCY1A2 antibody

Guanylate cyclase soluble subunit alpha-2, GUC1A2, GUCSA2

SwissProt ID

P33402 (Human), Q9WVI4 (Rat)

Gene ID

2977 (GUCY1A2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of GCS-alpha-2 / GUCY1A2 antibody

The cellular levels of Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, are maintained by the orchestrated activities of two opposing enzymes: synthesizing gualylyl cyclases (GC) and hydrolyzing phosphodiesterases (PDEs). The synthesizing enzymes (GCs) are found in two forms: cytosolic (soluble) and membrane-bound (particulate). In last several years new members of particulate guanylate cyclase family have been identified and significant progress is made in understanding the molecular mechanisms that underlie the regulation of these family of enzymes. In response to G-protein couples receptor stimulation, the cGMP can be produced from GTP by either cytoplasmic, soluble guanylate cyclase (sGC) are heterodimers (a and b polypeptide chains), that are stimulated by nitric oxide and carbon monoxide or by particulate membrane-bound guanylyl cyclases which are activated by a complex mechanism by natriuretic peptides. Particulate GC (PGCs) have 7 different isoforms, PGC-A through PGC-G and are expressed in most tissues in isoform specific manner (See Table 1). There is significant structural homology among various PGCs, there is a large N-terminal extracellular domain (ECD), a single TMD and a large intracellular domain with protein kinase activity (KLD), a C-terminal catalytic domain (CD) and in between is a dimmerization domain (DD). It has been shown that a significant number hippocampal astrocytes (67%) contained both soluble and particulate guanylate cyclases in the same cell (2).

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GCS-alpha-2 / GUCY1A2 antibody

Host: Rabbit; Target Name: GUCY1A2; Sample Tissue: HepG2 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

GCS-alpha-2 / GUCY1A2 control peptide

GCS-alpha-2 / GUCY1A2
0.25 mg / €250.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 (N-term) antibody

Western blot using Soluble Guanylyl Cyclase alpha 2 antibody at 1/750 dilution Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 control peptide

GCS-alpha-2 / GUCY1A2
0.25 mg / €250.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 (C-term) antibody

Western blot using Soluble Guanylyl Cyclase alpha 2 antibody at 1/750 dilution Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GCS-alpha-2 / GUCY1A2 antibody

GUCY1A2 polyclonal antibody (A01), Lot # 050920JC01 Western Blot analysis of GUCY1A2 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

GCS-alpha-2 / GUCY1A2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCY1A2 polyclonal antibody ( Cat # PAB2682 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

GCS-alpha-2 / GUCY1A2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with GUCY1A2 polyclonal antibody ( Cat # PAB4064 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GCS-alpha-2 / GUCY1A2

GCS-alpha-2 / GUCY1A2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GCS-alpha-2 / GUCY1A2

GCS-alpha-2 / GUCY1A2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GUCY1A2 overexpression lysate

GUCY1A2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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