GDF15 antibody
Principal name
GDF15 antibody
Alternative names for GDF15 antibody
GDF-15, MIC1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, MIC-1, Prostate differentiation factor, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)
Background of GDF15 antibody
Growth and differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1(MIC-1), placental transforming growth factor-., prostate-derived factor, and placental bone morphogenetic protein, is a divergent member of the transforming growth factor beta (TGF-.) superfamily . GDF-15 is initially synthesized as a 40 kDa inactive precursor protein. It is then proteolytically cleaved to release the active C-terminal fragment, which is assembled into a disulfide-linked homodimer of 28 kDa to become biologically active GDF-15 . In humans, GDF-15 is predominantly expressed in the placenta, with low levels in the kidney,pancreas, and prostate. However, its expression can be rapidly induced by cytokines such as interleukin-1 and TGF-. .
GDF-15 has diverse biological functions. Early studies have shown that low serum GDF-15 levels correlate with miscarriages, indicating that it might be able to suppress inflammation in early pregnancy . GDF-15 also plays an important role in tumorigenesis and metastasis. It has been observed that in many types of cancers, such as colorectal, breast, and prostate, theexpression of GDF-15 is dramatically increased . Additionally, in cancer patients, serum levels of GDF-15 are elevated, which are of value in disease diagnosis and stratification (10 -12). GDF-15 is strongly induced by the tumor suppressor gene p53 and other anti-tumorigenic agents, such as the non-steroidal anti-inflammatory drugs and peroxisome proliferators-activated receptor .. These findings suggest that GDF-15 may be a downstream target of those signaling pathways that regulate cell cycle arrest and apoptosis . Through the modulation of neuronal pathways important in the regulation of appetite and energy homeostasis, GDF-15 mediates cancer-induced anorexia and weight loss .
General readings
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Agarwal, M.K. et al. (2006) Proc. Natl. Acad. Sci. USA 103:16278.
Johnen, H. et al. (2007) Nat. Med. 13:1333.


































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA326764 | GDF15 antibody |
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Rabbit anti-GDF15 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA302498 | GDF15 (C-term) antibody |
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Goat Polyclonal Antibody against GDF15 | |||||||
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Goat | Aff - Purified | Hu, Ms, Rt | WB |
0.1 mg /
€360.00
|
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OriGene Technologies, Inc. | |||||||
TA312174 | GDF15 antibody |
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Rabbit polyclonal anti-GDF15 antibody | |||||||
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Rabbit | IgG | Purified | Hu | E, WB |
0.1 ml /
€335.00
|
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OriGene Technologies, Inc. | |||||||
TA317816 | GDF15 (30-45) antibody |
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GDF15 Rabbit Polyclonal (aa30-45) Antibody | |||||||
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Rabbit | Purified | Hu | E, P |
50 µg /
€400.00
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OriGene Technologies, Inc. | |||||||
TA318039 | GDF15 (C-term) antibody |
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GDF15 Goat Polyclonal (C-Terminus) Antibody | |||||||
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Goat | IgG | Aff - Purified | Hu, Ms, Rt | E, P, WB |
50 µg /
€400.00
|
|
OriGene Technologies, Inc. | |||||||
TA318812 | GDF15 antibody |
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GDF15 Rat Monoclonal (6D12.H10.E4) Antibody | |||||||
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Rat | IgG | 6D12.H10.E4 | Purified | Hu, Ms |
50 µg /
€400.00
|
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OriGene Technologies, Inc. | |||||||
TA319178 | GDF15 (D variant) antibody |
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Rabbit polyclonal anti-Nag-1 antibody | |||||||
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Rabbit | IgG | Aff - Purified | Chimp, Hu, Macaque, Ms, Rt | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319179 | GDF15 antibody |
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Rabbit polyclonal Nag-1 antibody Peroxidase Conjugated | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
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TA319180 | GDF15 (H variant) antibody |
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Rabbit polyclonal anti-Nag-1 antibody | |||||||
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Rabbit | IgG | Aff - Purified | Chimp, Hu, Macaque, Ms, Rt | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319181 | GDF15 antibody |
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Rabbit polyclonal Nag-1 antibody Biotin Conjugated | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, P, WB |
0.1 mg /
€503.00
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|
OriGene Technologies, Inc. | |||||||
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TA319182 | GDF15 (N-term) (H/D variant) antibody |
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Rabbit polyclonal anti-Nag-1 antibody | |||||||
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Rabbit | IgG | Aff - Purified | Chimp, Hu, Macaque, Ms, Rt | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319470 | GDF15 (C-term) antibody |
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Rabbit polyclonal anti-NAG-1 antibody | |||||||
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Rabbit | IgG | Ig Fraction | Hu, Ms | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319471 | GDF15 antibody |
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Rabbit polyclonal anti-Nag-1 antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319546 | GDF15 antibody |
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Mouse monoclonal NAG-1 H Variant antibody | |||||||
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Mouse | 7C12.B3.F2 | Purified | Hu | E, WB |
0.1 mg /
€503.00
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|
OriGene Technologies, Inc. | |||||||
TA319547 | GDF15 antibody |
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Mouse monoclonal anti-NAG-1 antibody | |||||||
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Mouse | 23B3D2.H5 | Purified | Hu | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA319548 | GDF15 antibody |
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Mouse monoclonal anti-NAG-1 antibody | |||||||
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Mouse | 23G10.F8 | Purified | Hu | E, WB |
0.1 mg /
€503.00
|
|
OriGene Technologies, Inc. | |||||||
TA321673 | GDF15 antibody |
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Anti-GDF15 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
TA321674 | GDF15 antibody |
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Anti-GDF15 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
AP09407PU-N | GDF15 (C-term) antibody |
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Rabbit | IgG | Aff - Purified | Chimp, Hu, Macaque, Ms, Rt | E, WB |
0.1 mg /
€460.00
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Acris Antibodies GmbH | |||||||
AP09407PU-S | GDF15 (C-term) antibody |
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Rabbit | IgG | Aff - Purified | Chimp, Hu, Macaque, Ms, Rt | E, WB |
25 µl /
€190.00
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Acris Antibodies GmbH |