Gelsolin antibody

Principal name

Gelsolin antibody

Alternative names for Gelsolin antibody

Brevin, AGEL, GSN, Actin-depolymerizing factor

SwissProt ID

O93510 (Chick), P06396 (Human), P13020 (Mouse), P20305 (Pig), Q28372 (Horse), Q3SX14 (Bovin), Q68FP1 (Rat)

Gene ID

2934 (GSN), 227753 (Gsn), 296654

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), Rb (Rabbit), Eq (Equine), Sh (Sheep)

Available hosts

Sheep, Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Gelsolin antibody

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. 
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

General readings

Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Gelsolin (Isoform a) antibody

AP31939PU-N Gelsolin antibody staining of Human Duodenum lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Gelsolin antibody

  Goat Polyclonal Antibody against GSN  
TA303164 (0.1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

  Anti-GSN Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human brain tissue using TA323717(GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

  Anti-GSN Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323718 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

  GSN Rabbit Polyclonal Antibody  
Western blot analysis of extracts of RAW264.7 cell lysate, using GSN antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

  Rabbit Polyclonal Anti-GSN Antibody  
WB Suggested Anti-GSN Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Rt, Sh, Ze ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

Gelsolin Mouse IgG1 GEL-42 Purified Hu, Rb C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Gelsolin antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G5 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Gelsolin (161-369) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Gelsolin antibody

Gelsolin Sheep Purified Bov, Hu, Ms, Por E
1 ml / €360.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GSN - human gene knockout kit via CRISPR

GSN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GSN - human gene knockout kit via CRISPR

GSN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR

Gsn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR

Gsn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR

Gsn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Gelsolin (transcript variant 1)

  Recombinant protein of human gelsolin (amyloidosis, Finnish type) (GSN), transcript variant 1  
Gelsolin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GSN overexpression lysate

GSN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GSN (mGFP-tagged) - Human gelsolin (GSN), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GSN (mGFP-tagged) - Human gelsolin (GSN), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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