Gelsolin antibody

Principal name

Gelsolin antibody

Alternative names for Gelsolin antibody

Brevin, AGEL, GSN, Actin-depolymerizing factor

SwissProt ID

O93510 (Chick), P06396 (Human), P13020 (Mouse), P20305 (Pig), Q28372 (Horse), Q3SX14 (Bovin), Q68FP1 (Rat)

Gene ID

2934 (GSN)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Rb (Rabbit), Can (Canine), Chk (Chicken), Ze (Zebrafish), Re (Reptiles), Eq (Equine), Sh (Sheep)

Available hosts

Sheep, Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of Gelsolin antibody

Gelsolin is a calcium-dependent actin capping and severing protein belonging to the villin/gelsolin family and serves to regulate several cellular functions: remodeling actin cytoskeleton, motility, morphology, secretion, and apoptosis. It is able to bind actin filaments and monomers at the plus end, effectively inhibiting the exchange of monomers. It is also able to sever preformed filaments and increase nucleation. When cleaved by caspase-3, the N-terminal end of gelsolin is active and pro-apoptotic, promoting the depolarization of actin and leading to cell death. However, studies have shown overepxression of gelsolin effectively inhibits caspase-3 and can therefore have a role in cell survival. Expression has been observed in fibroblasts, nonmuscle cells, phagocytic cells, platelets, skeletal and smooth muscle cells. Mutations in gelsolin expression are causal to amyloidosis type 5 (AMYL5). High levels of expression have been linked to human heart failure progression.

General readings

Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Gelsolin (Isoform a) antibody

AP31939PU-N Gelsolin antibody staining of Human Duodenum lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Gelsolin antibody

TA303164 (0.1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

Immunohistochemistry of paraffin-embedded Human brain tissue using TA323717(GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323718 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

Western blot analysis of extracts of RAW264.7 cell lysate, using GSN antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

WB Suggested Anti-GSN Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Rt, Sh, Ze ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody

Gelsolin Mouse IgG1 GEL-42 Purified Hu, Rb C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Gelsolin antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G5 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Gelsolin (161-369) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Gelsolin antibody

Gelsolin Sheep Purified Bov, Hu, Ms, Por E
1 ml / €360.00
  Acris Antibodies GmbH

Gelsolin antibody

Gelsolin Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Gelsolin antibody

GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in human stomach. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Gelsolin antibody

GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in human stomach. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Gelsolin antibody

Gelsolin Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Gelsolin antibody

GSN MaxPab rabbit polyclonal antibody. Western Blot analysis of GSN expression in human liver. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Gelsolin antibody

Immunoperoxidase of monoclonal antibody to GSN on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml] Mouse IgG1 3G5 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Gelsolin antibody

Immunoblot analysis of human plasma protein and cell lysates. Lane 1 : Gelsolin isolated from human plasma. Lane 2 : Human plasma. Lane 3 : NIH : OVCAR-3 cell lysate. Lane 4 : MCF-7 cell lysate. Mouse IgG1 35B2 Hu IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Gelsolin antibody

GSN polyclonal antibody ( Cat # PAB7148 ) ( 0.1 µg/ml ) staining of human spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Gelsolin antibody

Human Tonsil; . IHC Information: Paraffin embedded tonsil tissue, tested with an antibody Dilution of 5 ug/ml.; GSN antibody - C-terminal region (ARP54299_P050) in Human Tonsil cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Gelsolin antibody

Gelsolin Mouse IgG1 GEL-42 Ascites Bov, Hu, Rb C, P, WB
0.1 mg / €290.00
  Boster Immunoleader

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