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Gelsolin antibody

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Principal name

Gelsolin antibody

Alternative names for Gelsolin antibody

Brevin, AGEL, GSN, Actin-depolymerizing factor

SwissProt ID

O93510 (Chick), P06396 (Human), P13020 (Mouse), P20305 (Pig), Q28372 (Horse), Q3SX14 (Bovin), Q68FP1 (Rat)

Gene ID

2934 (GSN), 227753 (Gsn), 296654

Ncbi ID

NP_000168.1, 9606, NP_000168, NM_000177, NM_146120, NM_001004080, NM_198252, NM_001127662, NM_001127663, NM_001127664, NM_001127665, NM_001127667, NM_001127666, NP_666232.2

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), Rb (Rabbit), Eq (Equine), Sh (Sheep)

Available hosts

Sheep, Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Gelsolin antibody

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. 
Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Defects in GSN are the cause of amyloidosis type 5 (AMYL5) [MIM:105120]; also known as familial amyloidosis Finnish type. AMYL5 is a hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

General readings

Shokouhi,G. Nephrol. Dial. Transplant. 23 (3), 1071 (2008)

H00002934-M01 - Gelsolin
Immunoperoxidase of monoclonal antibody to GSN on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml]
H00002934-M01 - Gelsolin
GSN monoclonal antibody (M01), clone 3G5 Western Blot analysis of GSN expression in HeLa ( Cat # L013V1 ).
H00002934-M01 - Gelsolin
Detection limit for recombinant GST tagged GSN is approximately 0.03ng/ml as a capture antibody.
PAB7148 - Gelsolin
GSN polyclonal antibody ( Cat # PAB7148 ) ( 0.1 µg/ml ) staining of human spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence.
MAB0786 - Gelsolin
Immunoblot analysis of human plasma protein and cell lysates. Lane 1 : Gelsolin isolated from human plasma. Lane 2 : Human plasma. Lane 3 : NIH : OVCAR-3 cell lysate. Lane 4 : MCF-7 cell lysate.
H00002934-B01 - Gelsolin
GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in human stomach.
H00002934-B01 - Gelsolin
Western Blot analysis of GSN expression in transfected 293T cell line (H00002934-T01) by GSN MaxPab polyclonal antibody.Lane 1: GSN transfected lysate(86.02 KDa).Lane 2: Non-transfected lysate.
H00002934-B01 - Gelsolin
GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in HepG2.
H00002934-B01P - Gelsolin
GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in human stomach.
H00002934-B01P - Gelsolin
Western Blot analysis of GSN expression in transfected 293T cell line (H00002934-T01) by GSN MaxPab polyclonal antibody.Lane 1: GSN transfected lysate(86.02 KDa).Lane 2: Non-transfected lysate.
H00002934-B01P - Gelsolin
GSN MaxPab polyclonal antibody. Western Blot analysis of GSN expression in HepG2.
H00002934-D01P - Gelsolin
GSN MaxPab rabbit polyclonal antibody. Western Blot analysis of GSN expression in human liver.
H00002934-D01P - Gelsolin
Western Blot analysis of GSN expression in transfected 293T cell line (H00002934-T01) by GSN MaxPab polyclonal antibody.Lane 1: GSN transfected lysate(85.70 KDa).Lane 2: Non-transfected lysate.
H00002934-D01P - Gelsolin
GSN MaxPab rabbit polyclonal antibody. Western Blot analysis of GSN expression in HepG2.
ARP54299_P050 - Gelsolin
Human Tonsil; . IHC Information: Paraffin embedded tonsil tissue, tested with an antibody Dilution of 5 ug/ml.; GSN antibody - C-terminal region (ARP54299_P050) in Human Tonsil cells using Immunohistochemistry
ARP54299_P050 - Gelsolin
Human Tonsil; GSN antibody - C-terminal region (ARP54299_P050) validated by WB using pFA fixed human tonsil tissue; GSN antibody - C-terminal region (ARP54299_P050) in Human Tonsil cells using Western Blot
ARP54299_P050 - Gelsolin
Human MCF7; WB Suggested Anti-GSN Antibody Titration: 0.2-1 ug/ml. Positive Control: MCF7 cell lysate; GSN antibody - C-terminal region (ARP54299_P050) in Human MCF7 cells using Western Blot
AP23589PU-N - Gelsolin
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
AP23589PU-N - Gelsolin
Immunofluorescence analysis of methanol-fixed HeLa, using Gelsolin antibody at 1/200 dilution.
AP23589PU-N - Gelsolin
Sample (30 µg of whole cell lysate). A: H1299. B: Hela. 7.5% SDS PAGE. GSN antibody diluted at 1/1000.
AM31077PU-N - Gelsolin
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
AM31077PU-N - Gelsolin
GSN monoclonal antibody (M01), clone 3G5 Western Blot analysis of GSN expression in HeLa.
AM31077PU-N - Gelsolin
Detection limit for recombinant GST tagged GSN is approximately 0.03ng/ml as a capture antibody.
AP31939PU-N - Gelsolin
AP31939PU-N Gelsolin antibody staining of Human Duodenum lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TP314871 - Gelsolin
TA303164 - Gelsolin
TA303164 (0.1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA323717 - Gelsolin
Immunohistochemistry of paraffin-embedded Human brain tissue using TA323717(GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200)
TA323717 - Gelsolin
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA323717 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200)
TA323718 - Gelsolin
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323718 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200)
TA323718 - Gelsolin
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA323718 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200)
TA327454 - Gelsolin
Western blot analysis of extracts of RAW264.7 cell lysate, using GSN antibody.
TA327454 - Gelsolin
Immunohistochemistry of paraffin-embedded human ovarian cancer tissue using GSN antibody.
TA336242 - Gelsolin
WB Suggested Anti-GSN Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate
TA336242 - Gelsolin
GSN antibody - C-terminal region validated by WB using pFA fixed human tonsil tissue
TA336242 - Gelsolin
IHC Information: Paraffin embedded tonsil tissue, tested with an antibody Dilution of 5 ug/ml.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Gelsolin (Isoform a) antibody
AP31939PU-N Gelsolin antibody staining of Human Duodenum lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH
 

Acris recommends this product for Western blotting.

Gelsolin antibody
  Goat Polyclonal Antibody against GSN  
TA303164 (0.1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Gelsolin antibody
  Anti-GSN Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human brain tissue using TA323717(GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.
+1 additional image

Gelsolin antibody
  Anti-GSN Rabbit Polyclonal Antibody  
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323718 (GSN Antibody)(left image) at dilution 1/40, the image on the right is treated with the synthetic peptide.(Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.
+1 additional image

Gelsolin antibody
  GSN Rabbit Polyclonal Antibody  
Western blot analysis of extracts of RAW264.7 cell lysate, using GSN antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.
+1 additional image

Gelsolin antibody
  Rabbit Polyclonal Anti-GSN Antibody  
WB Suggested Anti-GSN Antibody Titration: 0.2-1 ug/ml; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Rt, Sh, Ze ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.
+2 additional images

Gelsolin antibody
Gelsolin Mouse IgG1 GEL-42 Purified Hu, Rb C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Gelsolin antibody
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3G5 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH
+2 additional images

Gelsolin (161-369) antibody
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Rt ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH
+2 additional images

Gelsolin antibody
Gelsolin Sheep Purified Bov, Hu, Ms, Por E
1 ml / €360.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GSN - human gene knockout kit via CRISPR
GSN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GSN - human gene knockout kit via CRISPR
GSN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR
Gsn - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR
Gsn - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gsn - mouse gene knockout kit via CRISPR
Gsn - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Gelsolin (transcript variant 1)
  Recombinant protein of human gelsolin (amyloidosis, Finnish type) (GSN), transcript variant 1  
Gelsolin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.		 HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GSN overexpression lysate
GSN overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GSN (mGFP-tagged) - Human gelsolin (GSN), transcript variant 1, 200 uL, >10^7 TU/mL
Lenti ORF particles, GSN (mGFP-tagged) - Human gelsolin (GSN), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 2, 200 uL, >10^7 TU/mL
Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.
 

Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 3, 200 uL, >10^7 TU/mL
Lenti ORF particles, GSN (mGFP-tagged)-Human gelsolin (GSN), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.
 

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