GEMC1 antibody

Principal name

GEMC1 antibody

Alternative names for GEMC1 antibody

Geminin coiled-coil domain-containing protein 1

SwissProt ID

A6NCL1 (Human), D3YN49, Q3URY2 (Mouse)

Gene ID

647309 (GMNC), 239789 (Gm606)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of GEMC1 antibody

The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GEMC1 (Center) antibody

  Rabbit Polyclonal GEMC1 Antibody  
Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide Rabbit Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

Gmnc - mouse gene knockout kit via CRISPR

Gmnc - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gmnc - mouse gene knockout kit via CRISPR

Gmnc - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gmnc - mouse gene knockout kit via CRISPR

Gmnc - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gmnc - mouse gene knockout kit via CRISPR

Gmnc - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GMNC overexpression lysate

GMNC overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GMNC (mGFP-tagged) - Human geminin coiled-coil domain-containing protein 1 (GEMC1), 200 uL, >10^7 TU/mL

Lenti ORF particles, GMNC (mGFP-tagged) - Human geminin coiled-coil domain-containing protein 1 (GEMC1), 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

Lenti ORF particles, GMNC (Myc-DDK tagged) - Human geminin coiled-coil domain-containing protein 1 (GEMC1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GMNC (Myc-DDK tagged) - Human geminin coiled-coil domain-containing protein 1 (GEMC1) , 200 uL, >10^7 TU/mL  
200 µl / €800.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gmnc (GFP-tagged) - Mouse predicted gene 606 (Gm606), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gmnc (GFP-tagged) - Mouse predicted gene 606 (Gm606), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gmnc (Myc-DDK-tagged) - Mouse predicted gene 606 (Gm606), 200 uL, >10^7 TU/mL

Lenti ORF particles, Gmnc (Myc-DDK-tagged) - Mouse predicted gene 606 (Gm606), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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