GEMC1 antibody

Principal name

GEMC1 antibody

Alternative names for GEMC1 antibody

Geminin coiled-coil domain-containing protein 1

SwissProt ID

A6NCL1 (Human), D3YN49, Q3URY2 (Mouse)

Gene ID

647309 (GMNC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of GEMC1 antibody

GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GEMC1 (Center) antibody

Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide Rabbit Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GEMC1 control peptide

Western blot analysis of GEMC1 in mouse heart tissue lysate with GEMC1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide
50 µg / €160.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

GMNC overexpression lysate

GMNC overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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