Gemin-5 antibody

Principal name

Gemin-5 antibody

Alternative names for Gemin-5 antibody

Gem-associated protein 5, GEMIN5

SwissProt ID

Q8BX17 (Mouse), Q8TEQ6 (Human)

Gene ID

25929 (GEMIN5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of Gemin-5 antibody

Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of motor neurons in the spinal cord (1). SMA is caused by deletion or loss-of-function mutations in the SMN (Survival of Motor Neuron) gene (2). Gemin5, the protein product of human chromosome 5q33.3 (3), associates directly with SMN and is a part of the SMN complex containing Gemin2, Gemin3, Gemin4 and Gemin6 as well as several spliceosomal snRNP proteins (2,4). The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing of the nucleus (2). The SMN complex is found in both the cytoplasm and the nucleus (2). The nuclear form is concentrated in subnuclear bodies called gems (Gemini of the coiled bodies) (2,5,6). Gemin5 interacts with several snRNP core proteins including SmB, SmD1, SmD2, SmD3 and SmE (7). The amino terminal half of Gemin5 contains 13 WD repeat domains and a coiled-coil motif near the C-terminus (7).

6 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Gemin-5 antibody

Western Blot and Immunoprecipitation: Gemin5 Antibody [NB100-61048] - Detection of Human Gemin5 on HeLa whole cell lysate using NB100-61048. Gemin5 was also immunoprecipitated by rabbit anti-Gemin5 antibody NB100-61049. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Gemin-5 antibody

Western Blot and Immunoprecipitation: Gemin5 Antibody [NB100-61049] - Detection of Human Gemin5 on HeLa whole cell lysate using NB100-61049. Gemin5 was also immunoprecipitated by rabbit anti-Gemin5 antibody NB100-61048. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Gemin-5 antibody

Immunohistochemistry-Paraffin: Gemin 5 Antibody [NBP1-90354] - Immunohistochemical staining of human cerebellum shows strong cytoplasmic and nucleolar positivity in purkinje cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Gemin-5

Gemin-5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Gemin-5

Gemin-5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Gemin-5

Gemin-5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

6 Item(s)

per page
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