GFAP antibody

Principal name

GFAP antibody

Alternative names for GFAP antibody

Glial Fibrillary Acidic Protein

SwissProt ID

P03995 (Mouse), P14136 (Human), P47819 (Rat), P48677 (Carau), Q28115 (Bovin), Q58EE9 (Danre), Q5RA72 (Ponab)

Gene ID

2670 (GFAP), 14580 (Gfap), 281189, 24387

Available reactivities

Fe (Feline), Hu (Human), Por (Porcine), Bov (Bovine), Chk (Chicken), GP (Guinea Pig), Hst (Hamster), Kangaroo, Mky (Monkey), Ms (Mouse), Rt (Rat), Sh (Sheep), Prim (Primate), Ze (Zebrafish), Mam (Mammalia), Can (Canine), Av (Birds), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Chicken, Guinea Pig, Goat, Rat

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), ELISA (capture) (E(capture)), Dot blot (Dot), Flow Cytometry (F), Luminex (LMNX)

Background of GFAP antibody

Glial Fibrillary Acidic Protein (GFAP) was discovered by Bignami et al. (1972) as a major fibrous protein of multiple sclerosis plaques. It was subsequently found to be a member of the 10 nm or intermediate filament protein family, specifically the intermediate filament protein family Class III, which also includes peripherin, desmin and vimentin.
GFAP is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. It is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes.
Although its function is not fully understood, GFAP protein is probably involved in controlling the shape and movement of astrocytes. The protein probably also plays a significant role in the interactions of astrocytes with other cells, which are required for the formation and maintenance of the insulating layer (myelin) that covers nerve cells. Additionally, GFAP protein may assist in maintaining the protective barrier that allows only certain substances to pass between blood vessels and the brain (blood-brain barrier).
In adults, GFAP levels increase as a result of the proliferation of astrocytes that occurs in a response to a variety of physical, chemical and etiological insults, including Alzheimer’s disease, epilepsy and multiple sclerosis.
Antibodies to GFAP are therefore very useful as markers of astrocytic cells and neural stem cells and for distinguishing of neoplasms of astrocytic origin from other neoplasms in the central nervous system.
Finally, Alexander's disease was recently shown to be caused by point mutations in protein coding region of the GFAP gene (Brenner et al., 2001). All forms of Alexander disease are characterized by the presence of Rosenthal fibers, which are GFAP containing cytoplasmic inclusions found in astrocytes.

General readings

Achtstätter T, Moll R, Anderson A, Kuhn C, Pitz S, Schwechheimer K, Franke WW: Expression of glial filament protein (GFP) in nerve sheaths and nonneural cells re-examined using monoclonal antibodies, with special emphasis on the co-expression of GFP and cytokeratins in epithelial cells of human salivary gland and pleomorphic adenomas. Differentiation 31, 206-227 (1986)
Gould VE, Koukoulis GK, Janssons DS, Nagle RB, Franke WW, Moll R: Coexpression patterns of vimentin and glial filament protein with cytokeratin in the normal, hyperplastic and neoplastic breast. Am J Pathol 137, 1143-1155 (1989)
Osborn M, Altmannsberger M, Debus E, Weber K: Differentiation of the major human tumor groups using conventional and monoclonal antibodies specific for individual intermediate filament proteins. Ann New York Acad Sci 455, 649-668 (1985)
Rungger-Brändle E, Achtstätter T, Franke WW: An epithelium-type cytokeratin in a glial cell: Astrocytes of amphibian optic nerves contain cytokeratin filaments and are connected by desmosomes. J Cell Biol 109, 705-716 (1989)
Gomi H, Yokoyama T, Fujimoto K, Ikeda T, Katoh A, Itoh T, Itohara S: Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions. Neuron 14, 29-41 (1995)
Akat K, Mennel H-D, Kremer P, Gassler N, Bleck CKE, Kartenbeck J: Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. Acta Neuropathol 106, 337-347 (2003)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GFAP antibody

GFAP Guinea Pig Serum Bov, Hu, Rt C, P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

GFAP antibody

Dissociated culture of Rat cerebral cortical neurons and astrocytes (red staining).  The nuclei of some neuronal cells (blue staining) are visible. Picture courtesy of Dr. Gerry Shaw, University of Florida. Chicken Ig Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €290.00
  Acris Antibodies GmbH

GFAP antibody

GFAP Mouse IgG1 GF-05 Purified Hu C, E, ICC/IF, WB
0.2 mg / €320.00
  Acris Antibodies GmbH

GFAP antibody

GFAP Mouse IgG1 UMAB5 Purified Hu, Rt ICC/IF, P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

GFAP antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-GFAP mouse monoclonal antibody. (UM500094; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB129 Purified Hu P, WB
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

GFAP antibody

GFAP Mouse IgG1 UMAB5 Purified Hu, Rt ICC/IF, P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

GFAP antibody

Immunohistochemical staining of paraffin-embedded Human embryonic cerebellum using anti-GFAP mouse monoclonal antibody. (UM500094; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB129 Purified Hu P, WB
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

GFAP antibody

Western blot analysis of extracts of mouse brain and mouse spinal cord, using GFAP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

GFAP antibody

Western Blot: GFAP Antibody [TA336611] - Western blot analysis of GFAP expression in whole rat cerebellum homogenate using TA336611. Rabbit Purified Bov, Can, Chk, Fe, Hu, Ms, Rt C, ICC/IF, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

GFAP antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-GFAP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500336) Mouse IgG2a OTI4C10 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GFAP antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-GFAP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500337) Mouse IgG1 OTI4G8 Purified Hu, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GFAP antibody

Immunohistochemical staining of paraffin-embedded Ovary tissue within the normal limits using anti-GFAPmouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500338, Dilution 1:50) Mouse IgG2b OTI4D11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GFAP antibody

Immunohistochemical staining of paraffin-embedded colon tissue within the normal limits using anti-GFAPmouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500340, Dilution 1:50) Mouse IgG2b OTI5D7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GFAP antibody

Immunofluorescent staining of A549 cells using anti-GFAP mouse monoclonal antibody (TA500341). Mouse IgG2b OTI2D8 Purified Hu, Mky, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GFAP (C-term) antibody

Human Eye stained with GFAP antibody Cat.-No AM09113PU Rabbit IgG SP78 Purified Hu P
0.5 ml / €510.00
  Acris Antibodies GmbH

GFAP (C-term) antibody

Human Eye stained with GFAP antibody Cat.-No AM09113PU Rabbit IgG SP78 Purified Hu P
1 ml / €730.00
  Acris Antibodies GmbH

GFAP (C-term) antibody

Human Eye stained with GFAP antibody Cat.-No AM09113PU Rabbit IgG SP78 Purified Hu P
0.1 ml / €290.00
  Acris Antibodies GmbH

GFAP antibody

Immunohistochemistry-Paraffin: GFAP Antibody (4D11) [NBP1-47782] - Immunohistochemical staining of paraffin-embedded prostate tissue using anti-GFAPmouse monoclonal antibody. (Dilution 1:50) Mouse 4D11 Aff - Purified Hu P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

GFAP antibody

Formalin-Paraffin Human brain stained with GFAP Antibody Cat.-No AM32829PU (Clone GA-5). Note cytoplasmic staining. Mouse IgG1 GA5 Purified Bov, Chk, Hu, Ms, Por, Rb, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

GFAP antibody

Formalin-Paraffin Human brain stained with GFAP Antibody Cat.-No AM32829PU (Clone GA-5). Note cytoplasmic staining. Mouse IgG1 GA5 Purified Bov, Chk, Hu, Ms, Por, Rb, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

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