GFI1B antibody

Principal name

GFI1B antibody

Alternative names for GFI1B antibody

Zinc finger protein Gfi-1b, Growth factor independent protein 1B, Potential regulator of CDKN1A translocated in CML

SwissProt ID

O42409 (Chick), O70237 (Mouse), Q5VTD9 (Human), Q6DCW1 (Xenla)

Gene ID

8328 (GFI1B), 14582 (Gfi1b)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of GFI1B antibody

Essential proto-oncogenic transcriptiol regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptiol repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine sigling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kise inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite D and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.

General readings

Huang,D.Y., et al., (2004) Nucleic Acids Res. 32 (13), 3935-3946

19 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GFI1B antibody

  Anti-GFI1B Rabbit Polyclonal Antibody  
Predicted band size: 37 kDa . Positive control: Raji cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GFI1B antibody

  Rabbit polyclonal GFI1B Antibody (C-term)  
GFI1B Antibody (C-term) (Cat. #TA325150) western blot analysis in HL-60,K562,U266 Rabbit IgG Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

GFI1B antibody

  Rabbit Polyclonal anti-GFI1B antibody  
WB Suggested Anti-GFI1B Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

GFI1B - human gene knockout kit via CRISPR

GFI1B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GFI1B - human gene knockout kit via CRISPR

GFI1B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GFI1B - human gene knockout kit via CRISPR

GFI1B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GFI1B - human gene knockout kit via CRISPR

GFI1B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gfi1b - mouse gene knockout kit via CRISPR

Gfi1b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Gfi1b - mouse gene knockout kit via CRISPR

Gfi1b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gfi1b - mouse gene knockout kit via CRISPR

Gfi1b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gfi1b - mouse gene knockout kit via CRISPR

Gfi1b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GFI1B overexpression lysate

GFI1B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GFI1B overexpression lysate

GFI1B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GFI1B (mGFP-tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GFI1B (mGFP-tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, GFI1B (mGFP-tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, GFI1B (mGFP-tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, GFI1B (Myc-DDK tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GFI1B (Myc-DDK tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Lenti ORF particles, GFI1B (Myc-DDK tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GFI1B (Myc-DDK tagged) - Human growth factor independent 1B transcription repressor (GFI1B), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Gfi1b (GFP-tagged) - Mouse growth factor independent 1B (Gfi1b), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gfi1b (GFP-tagged) - Mouse growth factor independent 1B (Gfi1b), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Gfi1b (Myc-DDK-tagged) - Mouse growth factor independent 1B (Gfi1b), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Gfi1b (Myc-DDK-tagged) - Mouse growth factor independent 1B (Gfi1b), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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