GFRA1 / GDNFR-alpha antibody

Principal name

GFRA1 / GDNFR-alpha antibody

Alternative names for GFRA1 / GDNFR-alpha antibody

GFR-alpha-1, GDNF receptor alpha, RET ligand 1, GDNFRA, RETL1, TRNR1, GDNF family receptor alpha-1, TGF-beta-related neurotrophic factor receptor 1

SwissProt ID

O13156 (Chick), P56159 (Human), P97785 (Mouse), Q62997 (Rat)

Gene ID

2674 (GFRA1), 25454 (Gfra1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Goat, Rabbit, Mouse, Chicken

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of GFRA1 / GDNFR-alpha antibody

The GDNF family ligands (GFLs) belong to the super family of the TGF-Ã?. They belong to the group of cystine-knot protein and function as homodimers. This family includes glial cell line-derived neurotrophic factor (GDNF), artemin (ARTN), Neurturin (NRTN) and persephin (PSPN).These factors are heavily involved in the development and function of the nervous system (both central and peripheral). In particular GDNF has an important role outside the nervous system where it plays a role in kidney morphogenesis.In general GFLs all sigl through a sigl through the receptor tyrosine kise Ret. Their specificity is implemented by different GDNF family receptor a (GFRa), which act as co-receptors. These extracellular proteins are bound to the plasma membrane via a glycosyl phosphatidyl inositol (GPI) anchor. GFRa1-4 are responsible for the binding of GDNF, NRTN, ARTN, and PSPN respectively and the subsequent activation of Ret. Soluble forms of the receptor by the cleavage of a yet unknown phospholipase or protease can be detected. Also altertive spliced forms of the protein can lead to soluble forms of GFRa receptors. In respect to their important role in development, individual knockout of either gdnf, gfra1 or ret gives rise to lethal phenotypes.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GFRA1 / GDNFR-alpha (Center) antibody

  Rabbit Polyclonal GFR alpha 1 Antibody  
Western blot analysis of GFR alpha 1 in crude membrane fractions of human brain (B), liver (L), kidney (K), and spleen (S), respectively, with GFR alpha 1 antibody at 1:500 dilution. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha antibody

  Rabbit polyclonal anti-GFR a-1 antibody  
Immunohistochemical analysis of paraffin-embedded human brain tissue, using GFR a-1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha antibody

  Anti-GFRA1 Rabbit Polyclonal Antibody  
Western blot analysis of Mouse brain tissue using TA322638(GFRA1 Antibody) at dilution 1/350 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha antibody

  Anti-GFRA1 Rabbit Polyclonal Antibody  
Predicted band size: 51 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/2000-5000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/1250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha antibody

  Rabbit polyclonal Anti-GDNF Family Receptor alpha1 (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1, 2. Anti-GDNF Family Receptor α1 (extracellular) antibody , (1:200). 3, 4. Anti-GDNF Family Receptor α1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha antibody

  Rabbit anti-GFRA1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using GFRA1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

GFRA1 / GDNFR-alpha (alpha) (24-440) antibody

Western blot analysis of GFRα1 expression in HCC-1500 (1), MCF-7 (2), BT-20 (3) and ZR-75-1 (4) using AM26644AF-N. Mouse IgG2b 4G10 Azide Free Hu WB
0.1 mg / €400.00
  Acris Antibodies GmbH

GFRA1 / GDNFR-alpha (alpha) (24-440) antibody

Immunoprecipitation of GFRα1 from HCC-1500 with AM26645AF-N (1) or isotype control (2). After immunoprecipitated with the antibody, immunocomplex was resolved on SDS-PAGE and immunoblotted with AM26645AF-N. Mouse IgG2b 3H8 Azide Free Hu F, IP
0.1 mg / €400.00
  Acris Antibodies GmbH

GFRA1 / GDNFR-alpha antibody

Immunohistochemistry analysis of GFRA1 / GDNFR-alpha Antibody (Cat.-No AP06136PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GFRA1 / GDNFR-alpha antibody

Immunofluorescence  detection of human GFRα-1 expressed in U2OS cells. GFRα-1 was visualized using Chicken polyclonal antibody to human GFRα-1 (dilution 1:2000) and Goat anti-chicken IgY - H&L DyLight 550 (dilution 1:200) as secondary antibody. For nuclear staining DAPI was used. ArrayScan VTI platform (Thermo Scientific) was used for image acquisition (10x objective). Composite picture was generated using pseudocolors green for GFRα-1 specific signal and blue for nuclei. Chicken IgY Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

GFRA1 / GDNFR-alpha antibody

Immunohistochemical staining of of human brain with Rabbit anti Human GDNFR alpha antibody Cat.-No SP1086P Rabbit Purified Hu P, WB
0.1 mg / €290.00
  Acris Antibodies GmbH

GFRA1 / GDNFR-alpha antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GFR alpha-1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €230.00
  Assay Biotech

GFRA1 / GDNFR-alpha antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GFR alpha-1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €330.00
  Assay Biotech

GFRA1 / GDNFR-alpha antibody

GFRA1 / GDNFR-alpha Goat Aff - Purified Hu, Rt C, E, P, WB
0.1 mg / €450.00
  Neuromics Antibodies

GFRA1 / GDNFR-alpha antibody

GFRA1 / GDNFR-alpha Goat Biotin Hu, Rt C, E, P, WB
50 µg / €470.00
  Neuromics Antibodies

GFRA1 / GDNFR-alpha antibody

GFRA1 / GDNFR-alpha Goat Aff - Purified Hu C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

GFRA1 / GDNFR-alpha antibody

GFRA1 / GDNFR-alpha Mouse IgG2b 81401 Purified Rt C, E, WB
0.5 mg / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

GFRA1 - human gene knockout kit via CRISPR

GFRA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GFRA1 - human gene knockout kit via CRISPR

GFRA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GFRA1 - human gene knockout kit via CRISPR

GFRA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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