GLP2 receptor antibody

Principal name

GLP2 receptor antibody

Alternative names for GLP2 receptor antibody

Glucagon-like peptide 2 receptor, GLP-2-R, GLP-2R, GLP2R

SwissProt ID

O95838 (Human), Q5IXF8 (Mouse), Q9Z0W0 (Rat)

Gene ID

9340 (GLP2R), 60432 (Glp2r)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Hu (Human), Mky (Monkey), Por (Porcine), Rb (Rabbit), Bear, Eq (Equine), Hst (Hamster), Ms (Mouse), Rt (Rat), Gorilla

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Dot blot (Dot)

Background of GLP2 receptor antibody

Glucagon-like peptide-2 (GLP-2) is a potent intestinotrophic/satiety hormone that acts through its G protein-coupled receptors (GLP1 and GLP2R). Tissue-specific posttranslational processing of proglucagon leads to GLP-2 and GLP-1 secretion from the intestine and glucagon secretion from the pancreas. Peptide hormones of the secretin-glucagon family are mainly expressed in endocrine cells of the pancreas, gastrointestinal epithelium and in specialized neurons in the brain (1). These peptide hormones subserve multiple biological functions, including regulation of growth, nutrient transit within the gut, digestion, energy absorption, and energy assimilation. The actions of these peptides are mediated by distinct members of the glucagon receptor super-family, all G protein-coupled receptors (GPCRs). GLP-2 also reduces gut permeability, bacterial translocation and pro-inflammatory cytokine expression under conditions of intestinal inflammation and injury. Glucagon, glucagon-like peptide-1 (GLP1), GLP2, glucose-dependent insulinotropic peptide, growth hormone-releasing hormone and secretin are structurally related peptides that exert their actions through members of related G protein-coupled receptor class 2 family (2). These receptors exhibit tissue-specific expression and significant structural homology associated with GPCRs (7 transmembrane domains) and share similar structural and functional properties with respect to ligand binding and signal transduction. GLP-2R expression is detected in multiple extrahypothalamic regions of the mouse and rat CNS, including cell groups in the cerebellum, medulla, amygdala, hippocampus, dentate gyrus, pons, cerebral cortex, and pituitary. The trophic actions of GLP-2 are specific for the intestine and are mediated by stimulation of crypt cell proliferation and reduced apoptosis in mucosal epithelial cells (2). Central infusion of GLP2 led to suppression of food intake (3). The effects of GLP-2 are mediated by G-Protein coupled GLP2-receptor, that is localized to the neuronal and endocrine cells of intestinal mucosa, but not in enterocytes, and hypothalamus which suggests that its actions are mediated indirectly via a secondary signaling mechanism.
Glucagon Like peptide 2 receptor (PGL2R) is G-protein coupled receptor containing 7 transmembrane domains (TMD) with 553 amino acids (66.7 kDa). The GLP2 receptor exhibit unique patterns of tissue-specific expression, considerable amino acid sequence identity, and share similar structural and functional properties with respect to other glucagons like peptide receptors.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GLP2 receptor (N-term, extracell. dom.) antibody

Anti-GLP2R antibody IHC of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hu, Mky, Por, Rb ICC/IF, IP, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

GLP2 receptor (internal) antibody

Anti-GLP2R antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Can, Elephant, Hu, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

Anti-GLP2R antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

GLP2 receptor (C-term) antibody

Anti-GLP2R antibody IHC of human small intestine, intraepithelial neuroendocrine cells and enterocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Eq, Hst, Hu, Mky, Ms P
50 µg / €345.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

Gel: 8%SDS-PAGE,Lysate: 40 µg,,Primary antibody:GLP2R Antibody at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

Western blot analysis of rat colon lysate: 1. Anti-Glucagon-like Peptide 2 Receptor (extracellular) antibody, (1:200). 2. Anti-Glucagon-like Peptide 2 Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

WB Suggested Anti-GLP2R Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GLP2 receptor control peptide

GLP2 receptor
0.25 mg / €250.00
  Acris Antibodies GmbH

GLP2 receptor antibody

GLP2 receptor Rabbit Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GLP2 receptor (Center) antibody

Western blot analysis of GLP2R Antibody (Center) Cat.-No AP51856PU-N in A549 cell line lysates (35ug/lane).This demonstrates the GLP2R antibody detected the GLP2R protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GLP2 receptor antibody

GLP2 receptor Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

GLP2 receptor antibody

Detection limit for recombinant GST tagged GLP2R is approximately 10ng/ml as a capture antibody. Mouse IgG2b 1F2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

GLP2 receptor antibody

Human HepG2; WB Suggested Anti-GLP2R Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HepG2 cell lysate; GLP2R antibody - N-terminal region (ARP58471_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

GLP2 receptor antibody

Immunohistochemistry-Paraffin: GLP2R Antibody [NBP1-44281] - Small intestine, Human: Formalin-Fixed Paraffin-Embedded Rabbit IgG Aff - Purified Hu P
50 µg / €440.00
  Novus Biologicals Inc.

GLP2 receptor antibody

Western Blot: GLP2R Antibody [NBP1-59029] - This Anti-GLP2R antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GLP2 receptor

GLP2 receptor Human
10 µg / €540.00
  Abnova Taiwan Corp.

GLP2 receptor

GLP2 receptor Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GLP2 receptor

GLP2 receptor Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

GLP2 receptor

GLP2 receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GLP2 receptor

GLP2 receptor Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

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