GLP2 receptor antibody

Principal name

GLP2 receptor antibody

Alternative names for GLP2 receptor antibody

Glucagon-like peptide 2 receptor, GLP-2-R, GLP-2R, GLP2R

SwissProt ID

O95838 (Human), Q5IXF8 (Mouse), Q9Z0W0 (Rat)

Gene ID

9340 (GLP2R), 60432 (Glp2r), 93896

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Bear, Mky (Monkey), Gorilla, Eq (Equine), Hst (Hamster), Bt (Bat), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Dot blot (Dot), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of GLP2 receptor antibody

Glucagon-like peptide-2 (GLP-2) is a potent intestinotrophic/satiety hormone that acts through its G protein-coupled receptors (GLP1 and GLP2R). Tissue-specific posttranslational processing of proglucagon leads to GLP-2 and GLP-1 secretion from the intestine and glucagon secretion from the pancreas. Peptide hormones of the secretin-glucagon family are mainly expressed in endocrine cells of the pancreas, gastrointestinal epithelium and in specialized neurons in the brain (1). These peptide hormones subserve multiple biological functions, including regulation of growth, nutrient transit within the gut, digestion, energy absorption, and energy assimilation. The actions of these peptides are mediated by distinct members of the glucagon receptor super-family, all G protein-coupled receptors (GPCRs). GLP-2 also reduces gut permeability, bacterial translocation and pro-inflammatory cytokine expression under conditions of intestinal inflammation and injury. Glucagon, glucagon-like peptide-1 (GLP1), GLP2, glucose-dependent insulinotropic peptide, growth hormone-releasing hormone and secretin are structurally related peptides that exert their actions through members of related G protein-coupled receptor class 2 family (2). These receptors exhibit tissue-specific expression and significant structural homology associated with GPCRs (7 transmembrane domains) and share similar structural and functional properties with respect to ligand binding and signal transduction. GLP-2R expression is detected in multiple extrahypothalamic regions of the mouse and rat CNS, including cell groups in the cerebellum, medulla, amygdala, hippocampus, dentate gyrus, pons, cerebral cortex, and pituitary. The trophic actions of GLP-2 are specific for the intestine and are mediated by stimulation of crypt cell proliferation and reduced apoptosis in mucosal epithelial cells (2). Central infusion of GLP2 led to suppression of food intake (3). The effects of GLP-2 are mediated by G-Protein coupled GLP2-receptor, that is localized to the neuronal and endocrine cells of intestinal mucosa, but not in enterocytes, and hypothalamus which suggests that its actions are mediated indirectly via a secondary signaling mechanism.
Glucagon Like peptide 2 receptor (PGL2R) is G-protein coupled receptor containing 7 transmembrane domains (TMD) with 553 amino acids (66.7 kDa). The GLP2 receptor exhibit unique patterns of tissue-specific expression, considerable amino acid sequence identity, and share similar structural and functional properties with respect to other glucagons like peptide receptors.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GLP2 receptor (N-term, extracell. dom.) antibody

  Glp-2 / GLP2R Rabbit Polyclonal (N-Terminus) Antibody  
Anti-GLP2R antibody IHC of human small intestine, neuroendocrine cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hu, Mky, Por, Rb ICC/IF, IP, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

GLP2 receptor (internal) antibody

  Glp-2 / GLP2R Rabbit Polyclonal (Internal) Antibody  
Anti-GLP2R antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Bear, Bov, Can, Elephant, Hu, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

  Glp-2 / GLP2R Rabbit Polyclonal (C-Terminus) Antibody  
Anti-GLP2R antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

GLP2 receptor (C-term) antibody

  Glp-2 / GLP2R Rabbit Polyclonal (C-Terminus) Antibody  
Anti-GLP2R antibody IHC of human small intestine, intraepithelial neuroendocrine cells and enterocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Eq, Hst, Hu, Mky, Ms P
50 µg / €400.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

  Anti-GLP2R Rabbit Polyclonal Antibody  
Gel: 8%SDS-PAGE,Lysate: 40 µg,,Primary antibody:GLP2R Antibody at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

  Rabbit Polyclonal Anti-Glucagon-like Peptide 2 Receptor (extracellular)  
Western blot analysis of rat colon lysate: 1. Anti-Glucagon-like Peptide 2 Receptor (extracellular) antibody, (1:200). 2. Anti-Glucagon-like Peptide 2 Receptor (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GLP2 receptor antibody

  Rabbit Polyclonal Anti-GLP2R Antibody - N-terminal region  
WB Suggested Anti-GLP2R Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GLP2 receptor (Center) antibody

Western blot analysis of GLP2R Antibody (Center) Cat.-No AP51856PU-N in A549 cell line lysates (35ug/lane).This demonstrates the GLP2R antibody detected the GLP2R protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GLP2R - human gene knockout kit via CRISPR

GLP2R - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GLP2R - human gene knockout kit via CRISPR

GLP2R - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GLP2R - human gene knockout kit via CRISPR

GLP2R - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GLP2R - human gene knockout kit via CRISPR

GLP2R - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Glp2r - mouse gene knockout kit via CRISPR

Glp2r - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Glp2r - mouse gene knockout kit via CRISPR

Glp2r - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Glp2r - mouse gene knockout kit via CRISPR

Glp2r - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Glp2r - mouse gene knockout kit via CRISPR

Glp2r - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Glp2r (GFP-tagged) - Mouse glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glp2r (GFP-tagged) - Mouse glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL  
200 µl / €1,140.00
  OriGene Technologies, Inc.

Lenti ORF particles, Glp2r (Myc-DDK-tagged) - Mouse glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glp2r (Myc-DDK-tagged) - Mouse glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Glp2r (GFP-tagged ORF) - Rat glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glp2r (GFP-tagged ORF) - Rat glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Glp2r (Myc-DDK-tagged ORF) - Rat glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glp2r (Myc-DDK-tagged ORF) - Rat glucagon-like peptide 2 receptor (Glp2r), 200 uL, >10^7 TU/mL  
200 µl / €1,061.00
  OriGene Technologies, Inc.

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