Glutamate receptor 2 / GLUR2 antibody

Principal name

Glutamate receptor 2 / GLUR2 antibody

Alternative names for Glutamate receptor 2 / GLUR2 antibody

GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA2, GRIA2, AMPA-selective glutamate receptor 2

SwissProt ID

P19491 (Rat), P23819 (Mouse), P42262 (Human)

Gene ID

2890 (GRIA1), 2891 (GRIA2), 29627 (Gria2)

Available reactivities

Rt (Rat), Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Ze (Zebrafish), African clawed frog, Mky (Monkey), Av (Birds)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoelectron Microscopy (EM), Radioimmunoassay (R), Flow Cytometry (F)

Background of Glutamate receptor 2 / GLUR2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (3, 4). GluR2 is possibly the most important AMPA receptor subunit, responsible for AMPA receptor rectifying properties, control of ion flow and in particular, the influx of calcium. The majority of GluR2 in the CNS is expressed in the GluR2 form, containing a critical arginine residue in the transmembrane region 2 domain, thereby rendering native AMPA receptors impermeable to calcium (5).

General readings

1. Sun W, Ferrer-Montiel AV, Montal M. Primary structure and functional expression of the AMPA/Kainate receptor subunit 2 from human brain. Neuroreport. 12 January 1999; 5(4):441-444.
2. Mayer ML. Glutamate receptor ion channels. Current Opinion in Neurobiology. 2005; 15(3):282-288.
3. Gryder DS, Castaneda DC, Rogawski MA. Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. J Neurochem. September 2005; 94(6):1728-1738.
4. Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S. Glutamate Receptors: RNA editing and death of motor neurons. Nature. 26 February 2004; 427(6977):801.
5. Deng YP, Xie JP, Wang HB, Lei WL, Chen Q, Reiner A. Differential localization of the GluR1and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats. J Chem Neuroanat. July 2007; 33(4):167-192.
6. Park J-S, voitenko N, Petralia RS, Guan X, Xu J-T, Steinberg JP, Takamiya K, Sotnik A, Kopach O, Huganir RL, Tao Y-X. Persistent inflammation induces GluR2 internalization via NMDA
receptor-triggered PKC activation in dorsal horn neurons. J Neurosci. 11 March 2009; 29(10): 3206-3219.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor 2 / GLUR2 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 L21/32 Supernatant Hu, Ms, Rt C, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Glutamate receptor 2 / GLUR2 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 L21/32 Purified Hu, Ms, Rt C, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Glutamate receptor 2 / GLUR2 (+ GLUR3) antibody

Human cerebellum stained with anti-GluR2/3 Rabbit Purified Av, Hu, Mky, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 (+ GLUR3) antibody

Human cerebellum stained with anti-GluR2/3 Rabbit Purified Av, Hu, Mky, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 (+ GLUR3) antibody

Human cerebellum stained with anti-GluR2/3 Rabbit Purified Av, Hu, Mky, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein. Rabbit IgG Aff - Purified Chk, Hu, Ms, non-Human Primates, Rt, Ze WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of extracts from COLO205/HuvEC cells, using GluR2 (Ab-880) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

Predicted cell location: Cytoplasm. Positive control: Human gastric and breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human gastric and breast cancer tissue using GRIA2 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and colon cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded Human liver and colon cancer tissue using GRIA2 antibody at dilution 1/70, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of GluR2 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S21-32 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of rat brain membranes: 1. Anti-AMPA Receptor 2 (GluA2) (extracellular) antibody, (1:200). 2. Anti-AMPA Receptor 2 (GluA2) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 pSer880 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (AP02530PU-S; AP02530PU-N, Lane 3 and 4). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 pSer880 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (AP02530PU-S; AP02530PU-N, Lane 3 and 4). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €240.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (Lane 3 and 4). Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (Lane 3 and 4). Rabbit Aff - Purified Hu, Ms WB
50 µl / €230.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Glutamate receptor 2 / GLUR2 Rabbit IgG Purified Chk, Hu, Mky, Ms, Rt, Ze WB
0.1 ml / €500.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 (+ GLUR3) antibody

Figure 1. Western blot of rat Hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein. Rabbit IgG Aff - Purified Chk, Hu, Ms, Rt, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 pSer880 antibody

Figure 1. Western blot of rat brain homogenate showing specific immunolabeling of the ~100k GluR2 protein phosphorylated at Ser880 (control). Immunolabeling is 
blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown). Rabbit IgG Aff - Purified Hu, Ms, non-Human Primates, Rt, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 control peptide

Glutamate receptor 2 / GLUR2
0.25 mg / €250.00
  Acris Antibodies GmbH

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