Glutamate receptor 2 / GLUR2 antibody

Principal name

Glutamate receptor 2 / GLUR2 antibody

Alternative names for Glutamate receptor 2 / GLUR2 antibody

GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA2, GRIA2, AMPA-selective glutamate receptor 2

SwissProt ID

P19491 (Rat), P23819 (Mouse), P42262 (Human)

Gene ID

2891 (GRIA2), 29627 (Gria2), 14800

Available reactivities

Bov (Bovine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Mky (Monkey), Av (Birds)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Glutamate receptor 2 / GLUR2 antibody

AMPA receptors are members of the glutamate receptor family of ion channels that also include the NMDA and Kaite receptors. The three subfamilies are med after the origil synthetic agonists that were identified as selective ligands of each family. The α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptor subfamily includes four members AMPA1-AMPA4 that are also known as GluR1-GluR4 respectively. The functiol AMPA channel is believed to be a tetramer, with most neurol AMPA receptors being actually heterotetramers composed of AMPA1 plus AMPA2 or AMPA2 plus AMPA3, although homotetramers can also be found. AMPA receptors are permeable to cations +, K+ and Ca2+. The Ca2+ permeability is dependent on the presence of AMPA2: whenever this subunit is present, the channel will be impermeable to Ca2+. The Ca2+ permeability of the AMPA2 subunit is determined by the presence of the amino acid arginine (R) at a critical site in the pore loop instead of glutamine (Q) present in the same site in the other AMPA subunits. A post-transcriptiol process known as R editing determines the presence of this R. Since most AMPA2 subunits in the adult brain have undergone R editing and most AMPA receptors contain the AMPA2 subunit, most tive AMPA receptors will be impermeable to Ca2+. Gating of AMPA receptors by glutamate is extremely fast and therefore the AMPA receptors mediate most excitatory (depolarizing) currents in the brain during basal neurol activity. The depolarization caused by the activation of post-syptic AMPA receptors is necessary for the activation of NMDA receptors that will open only in the presence of both glutamate and a depolarized membrane. Syptic strength, defined as the level of post-syptic depolarization, can be long term (hence the term long term potentiation, LTP) and therefore induce changes in sigling and protein synthesis in the activated neuron. These changes are associated with memory formation and learning. Changes in syptic strength are thought to involve rapid movement of the AMPA receptors in and out of the sypses and a great deal of effort has been focused on understanding the mechanisms that govern AMPA receptor trafficking.

General readings

1. Sun W, Ferrer-Montiel AV, Montal M. Primary structure and functional expression of the AMPA/Kainate receptor subunit 2 from human brain. Neuroreport. 12 January 1999; 5(4):441-444.
2. Mayer ML. Glutamate receptor ion channels. Current Opinion in Neurobiology. 2005; 15(3):282-288.
3. Gryder DS, Castaneda DC, Rogawski MA. Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala. J Neurochem. September 2005; 94(6):1728-1738.
4. Kawahara Y, Ito K, Sun H, Aizawa H, Kanazawa I, Kwak S. Glutamate Receptors: RNA editing and death of motor neurons. Nature. 26 February 2004; 427(6977):801.
5. Deng YP, Xie JP, Wang HB, Lei WL, Chen Q, Reiner A. Differential localization of the GluR1and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats. J Chem Neuroanat. July 2007; 33(4):167-192.
6. Park J-S, voitenko N, Petralia RS, Guan X, Xu J-T, Steinberg JP, Takamiya K, Sotnik A, Kopach O, Huganir RL, Tao Y-X. Persistent inflammation induces GluR2 internalization via NMDA
receptor-triggered PKC activation in dorsal horn neurons. J Neurosci. 11 March 2009; 29(10): 3206-3219.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor 2 / GLUR2 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 L21/32 Supernatant Hu, Ms, Rt C, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

Glutamate receptor 2 / GLUR2 antibody

Adult rat hippocampus immunohistochemistry Mouse IgG1 L21/32 Purified Hu, Ms, Rt C, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

Glutamate receptor 2 / GLUR2 antibody

  Rabbit Anti-GluR2 Antibody  
Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein. Rabbit IgG Aff - Purified Chk, Hu, Ms, non-Human Primates, Rt, Ze WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Rabbit Anti-GluR2-subunit (Ser880) Antibody (Phospho-Specific)  
Western blot of rat brain homogenate showing specific immunolabeling of the  ~100k GluR2 protein phosphorylated at Ser880 (control).  Immunolabeling is  blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown). Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Rabbit polyclonal Glutamate receptor 2 (Ab-880) antibody  
Western blot analysis of extracts from COLO205/HuvEC cells, using GluR2 (Ab-880) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Rabbit polyclonal Glutamate receptor 2 (Ser880) antibody(Phospho-specific)  
Western blot analysis of extracts from mouse brain, using Glutamate receptor 2 (phospho-Ser880) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Anti-GRIA2 (phospho-Ser880) Rabbit Polyclonal Antibody  
Predicted band size: 99 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Treated with the peptide Lane2: Mouse brain tissue lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Anti-GRIA2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human gastric and breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human gastric and breast cancer tissue using GRIA2 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Anti-GRIA2 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human liver and colon cancer tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded Human liver and colon cancer tissue using GRIA2 antibody at dilution 1/70, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Mouse Monoclonal Anti-GluR2 Antibody  
Western blot analysis of GluR2 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S21-32 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 antibody

  Rabbit Polyclonal Anti-AMPA Receptor 2 (GluA2) (extracellular)  
Western blot analysis of rat brain membranes: 1. Anti-AMPA Receptor 2 (GluA2) (extracellular) antibody, (1:200). 2. Anti-AMPA Receptor 2 (GluA2) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor 2 / GLUR2 pSer880 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (AP02530PU-S; AP02530PU-N, Lane 3 and 4). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 pSer880 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (AP02530PU-S; AP02530PU-N, Lane 3 and 4). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €240.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (Lane 3 and 4). Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Western blot analysis of extract from mouse brain tissue, using Glutamate receptor 2 (Precursor)antibody (Lane 1 and 2) and Glutamate receptor 2 (Precursor)(pSer880) antibody (Lane 3 and 4). Rabbit Aff - Purified Hu, Ms WB
50 µl / €240.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Glutamate receptor 2 / GLUR2 Rabbit IgG Purified Chk, Hu, Mky, Ms, Rt, Ze WB
0.1 ml / €500.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Brain, cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 (+ GLUR3) antibody

Figure 1. Western blot of rat Hippocampal lysate showing specific immunolabeling of the ~100k GluR2/3 protein. Rabbit IgG Aff - Purified Chk, Hu, Ms, Rt, Ze WB
0.1 ml / €380.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 antibody

Immunohistochemistry analysis of GluR2 antibody (Cat.-No AP20753PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Glutamate receptor 2 / GLUR2 pSer880 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using GluR2 (Phospho-Ser880) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

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