Glutamate receptor 4 / GLUR4 antibody

Principal name

Glutamate receptor 4 / GLUR4 antibody

Alternative names for Glutamate receptor 4 / GLUR4 antibody

GluR-4, GRIA4, GluR-D, GluA4, Glutamate receptor ionotropic AMPA4, AMPA-selective glutamate receptor 4

SwissProt ID

P19493 (Rat), P48058 (Human), Q9Z2W8 (Mouse)

Gene ID

2893 (GRIA4), 29629 (Gria4)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey), Ze (Zebrafish)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of Glutamate receptor 4 / GLUR4 antibody

Glutamate is the major excitatory neurotransmitter and modulates its effects via ionotropic and metabotropic receptors which are different in their molecular, biochemical, pharmacological and physiological properties. The ionotropic ligand-gated ion channel glutamate receptors are classified into three major subtypes, AMPA, kaite and NMDA receptors according to their selective agonist. AMPA receptors consist of four closely related genes with about 70% homology that encode the four subunits GluR1-4. Their expression is known to be developmentally regulated and are also known to undergo altertive splicing. In fact, all four receptors have two splice variants, termed flip and flop, in an extracellular region adjacent to the M4 transmembrane region. These splice variants are also developmentally regulated such that flip is expressed before birth and remains highly expressed throughout adulthood whereas flop expression is posttal and reaches flip’s level in adulthood. In addition to their expression regulation, flip and flop also differ in their activation/ictivation kinetics. Each AMPA receptor contains 3 membrane spanning domains (M1, M3 and M4), while the fourth hydrophobic domain (M2) is a reentering cytoplasmic loop that forms part of the channels pore. Different stoichiometries of these receptors form tetrameric structures to eventually form functiol receptors. AMPA receptors are highly expressed in the brain. However, the GluR4 subunit is present in lower amounts in the CNS, except in the reticular thalamic neuclei and the cerebellum. The primary depolarization in glutamate neurotransmission is mediated by AMPA receptors, which are also key players in syptic plasticity, learning and memory formation. The cellular distribution and post-translatiol modifications like phosphorylation are important for the activity of AMPA receptors and are thought to play a role in the long lasting and activity-dependent changes in syptic strength.

General readings

Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Volpi, S., et al. J Clin Psychiatry 70(6):801-809(2009)
Kessels, H.W., et al. Neuron 61(3):340-350(2009)
Arai, S., et al. Psychiatr. Genet. 19(1):6-13(2009)
Aruscavage, P.J., et al. RNA 6(2):257-269(2000)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor 4 / GLUR4 antibody

TA305853 (0.3ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 4 / GLUR4 antibody

Western blot analysis of rat brain membranes (lanes 1 and 3) and mouse brain lysate (lanes 2 and 4): 1, 2. Anti-AMPA Receptor 4 (GluA4) (extracellular) antibody, (1:200). 3, 4. Anti-AMPA Receptor 4 (GluA4) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor 4 / GLUR4 antibody

Immunohistochemistry (IHC) analyzes of GluR4 antibody (Cat.-No.: AP20233PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Glutamate receptor 4 / GLUR4 (279-292) antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with GRIA4 antibody AP22578PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bov, Bt, Can, Chk, Eq, Fi, Hu, L, Mky, Ms, Op, Prim, Rb, Rt, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor 4 / GLUR4 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with Glutamate receptor 4 / GLUR4 Antibody (Center) Cat.-No AP51950PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Glutamate receptor 4 / GLUR4 (Center) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with Glutamate receptor 4 / GLUR4 Antibody (Center) Cat.-No AP51951PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Glutamate receptor 4 / GLUR4 antibody

GRIA4 polyclonal antibody ( Cat # PAB11410 ) ( 0.3 µg/ml ) staining of human cerebellum lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Glutamate receptor 4 / GLUR4 pSer862 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using GluR4 (Phospho-Ser862) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

Glutamate receptor 4 / GLUR4 pSer862 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using GluR4 (Phospho-Ser862) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

Glutamate receptor 4 / GLUR4 antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with Forskolin 40nM 30', using GluR4 (Ab-862) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Glutamate receptor 4 / GLUR4 antibody

Western blot analysis of extracts from NIH-3T3 cells, treated with Forskolin 40nM 30', using GluR4 (Ab-862) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Glutamate receptor 4 / GLUR4 pSer862 antibody

Western blot analysis of GLUR4 (pS862) expression in MCF7 Forskonlin-treated (A); mouse brain (B); mouse spleen (C); rat spleen (D) whole cell lysates. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt, Ze WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

Glutamate receptor 4 / GLUR4 pSer862 antibody

Western blot analysis of GLUR4 (pS862) expression in MCF7 Forskonlin-treated (A); mouse brain (B); mouse spleen (C); rat spleen (D) whole cell lysates. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt, Ze WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

Glutamate receptor 4 / GLUR4 pSer862 antibody

Western blot analysis of GLUR4 (pS862) expression in MCF7 Forskonlin-treated (A); mouse brain (B); mouse spleen (C); rat spleen (D) whole cell lysates. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt, Ze WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

Glutamate receptor 4 / GLUR4 antibody

GluR4 staining of human brain tissue, cortex (formalin-fixed paraffin-embedded) at 5 ug/ml followed by biotinylated horse anti-goat IgG secondary antibody,  alkaline phosphatase-streptavidin and chromogen. Protocol on data-sheet. Goat IgG Aff - Purified Bov, Hu, Ms, Rt E, P, WB
0.1 mg / €400.00
  Neuromics Antibodies

Glutamate receptor 4 / GLUR4 antibody

Immunohistochemistry-Paraffin: Glutamate Receptor 4 Antibody [NBP1-02312] - (5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat IgG Aff - Purified Bov, Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Glutamate receptor 4 / GLUR4 antibody

Glutamate receptor 4 / GLUR4 Rabbit Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Glutamate receptor 4 / GLUR4 antibody

Western Blot: Glutamate receptor 4 Antibody (EPR2512(2)) [NBP1-95770] - SY5Y lysates using anti-GluR4. Rabbit EPR2512(2) Purified Hu, Ms, Rt F, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Glutamate receptor 4 / GLUR4

Glutamate receptor 4 / GLUR4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Glutamate receptor 4 / GLUR4

Glutamate receptor 4 / GLUR4 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

20 Item(s)

per page
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