Glutamate receptor 5 / GLUR5 antibody

Principal name

Glutamate receptor 5 / GLUR5 antibody

Alternative names for Glutamate receptor 5 / GLUR5 antibody

Excitatory amino acid receptor 3, EAA3, GRIK1, Glutamate receptor ionotropic kainate 1

SwissProt ID

P22756 (Rat), P39086 (Human), Q60934 (Mouse)

Gene ID

2897 (GRIK1), 29559 (Grik1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Goat, Sheep, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Dot blot (Dot), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Frozen Sections (C)

Background of Glutamate receptor 5 / GLUR5 antibody

L-Glutamate, the major excitatory neurotransmitter in the central nervous system (CNS), operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein-coupled receptors). The ligand-gated ion channel family consists of fifteen members that have been subdivided into three families based upon their pharmacological profile: the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring receptors, the N-methyl-D-aspartate (NMDA)-preferring receptors, and the kaite-preferring receptors. The kaite receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functiol characteristics. GluR5, GluR6, and GluR7receptor subunits share a high degree of homology and are able to form functiol channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are uble to form functiol channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kaite. Like AMPA receptors, the functiol unit of endogenous kaite receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kaite receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo R editing; as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+. GluR5 is highly expressed in dorsal root ganglion (DRG) neurons of the peripheral nervous system (PNS) as well as in several structures of the CNS including the amygdala, the hipoccampus, and Purkinje cells of the cerebellum. GluR5 has been implicated in the modulation of syptic transmission and syptic plasticity in both the CNS and PNS, but the exact physiological function of GluR5 is not well understood. Nevertheless, an involvement in persistent pain and some types of learning has been proposed.

General readings

Martin S, Nishimune A, Mellor JR, Henley JM.
SUMOylation regulates kainate-receptor-mediated synaptic transmission.
Nature. 2007 May 17;447(7142):321-5. Epub 2007 May 7.
PMID: 17486098

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor 5 / GLUR5 antibody

TA303274 (1µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 (C-term) antibody

Western blot analysis of Grik1 in P815 cell lysate with Grik1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 (Center) antibody

Western blot analysis of Grik1 in rat brain tissue lysate with Grik1 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 antibody

Western blot analysis on mouse brain cell lysate using GluR5 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 antibody

Western blot analysis of extracts from mouse brain, using GluR5 antibody (#TA326102).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 antibody

Western blot analysis of rat brain membranes: 1. Anti-Kainate Receptor GluK1 (extracellular) antibody, (1:200). 2. Anti-Kainate Receptor GluK1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor 5 / GLUR5 antibody

Immunohistochemistry (IHC) analyzes of GluR5 antibody (Cat.-No.: AP06140PU-) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 Control Peptide

Glutamate receptor 5 / GLUR5
0.25 mg / €250.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 antibody

Western Blot of GluR5 antibody (Cat#AP09862PU-N) at 1/500 dilution. Rabbit Aff - Purified Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 (C-term) antibody

Human Lung (formalin-fixed, paraffin-embedded) stained with GRIK1 antibody AP22600PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with GRIK1 antibody AP22601PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 Control Peptide

Glutamate receptor 5 / GLUR5
50 µg / €160.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 Control Peptide

Glutamate receptor 5 / GLUR5
50 µg / €160.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 antibody

Glutamate receptor 5 / GLUR5 Sheep Purified Hu E
1 ml / €450.00
  Acris Antibodies GmbH

Glutamate receptor 5 / GLUR5 antibody

Glutamate receptor 5 / GLUR5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Glutamate receptor 5 / GLUR5 antibody

Glutamate receptor 5 / GLUR5 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Glutamate receptor 5 / GLUR5 antibody

GRIK1 polyclonal antibody ( Cat # PAB7354 ) ( 1 µg/ml ) staining of human brain ( cerebellum ) lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Glutamate receptor 5 / GLUR5 antibody

Immunohistochemical staining of human brain tissue using GRIK1 polyclonal antibody ( Cat # PAB13311 ) at 2.5 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Glutamate receptor 5 / GLUR5 antibody

Immunohistochemical staining of human brain tissue using GRIK1 polyclonal antibody ( Cat # PAB13312 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Glutamate receptor 5 / GLUR5 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using GluR5 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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