Glutamate receptor 6 / GLUR6 antibody
Principal name
Glutamate receptor 6 / GLUR6 antibody
Alternative names for Glutamate receptor 6 / GLUR6 antibody
GRIK2, Excitatory amino acid receptor 4, EAA4, Glutamate receptor ionotropic kainate 2
Ncbi ID
NP_786944, 9606, NP_001159719.1, NP_068775, AAH63814.1, Q13002, NP_062182.1, NM_019309, NM_021956, NM_175768
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Enzyme Immunoassay (E)
Background of Glutamate receptor 6 / GLUR6 antibody
L-Glutamate, the major excitatory neurotransmitter in the central nervous system (CNS), operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein-coupled receptors). The ligand-gated ion channel family consists of fifteen members that have been subdivided into three families based upon their pharmacological profile: the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-preferring receptors, the N-methyl-D-aspartate (NMDA)-preferring receptors, and the kaite-preferring receptors. The kaite receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functiol characteristics. GluR5, GluR6, and GluR7 receptor subunits share a high degree of homology and are able to form functiol channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are uble to form functiol channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kaite. Like AMPA receptors, the functiol unit of endogenous kaite receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kaite receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo R editing; as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+. GluR6 is expressed in the CNS in basal ganglia, cerebellum, and hipoccampus, as well as in the spil cord. The exact physiological role of GluR6 is unclear, but a role in controlling neurol excitability, syptic integration, and syptic plasticity has been proposed.
General readings
Bah,J., et al., (2004) Neuroreport 15 (12), 1987-1991






Lane 1: Hela whole cell lysate
Lane 2: NIH-3T3 whole cell lysate
Lane 3: Raw264.7 whole cell lysate
Lane 4: H9C2 whole cell lysate






Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA306496 | Glutamate receptor 6 / GLUR6 (C-term) antibody |
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Rabbit Polyclonal Grik2 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, WB |
0.1 mg /
€371.00
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OriGene Technologies, Inc. | |||||||
TA328828 | Glutamate receptor 6 / GLUR6 antibody |
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Rabbit Polyclonal Anti-Kainate Receptor GluK2 | |||||||
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Rabbit | Purified | Hu, Ms, Rt | WB |
0.2 ml /
€622.00
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OriGene Technologies, Inc. | |||||||
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TA332468 | Glutamate receptor 6 / GLUR6 antibody |
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Rabbit anti-GRIK2 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA338702 | Glutamate receptor 6 / GLUR6 antibody |
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Rabbit Polyclonal Anti-GRIK2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
0.1 mg /
€360.00
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|
OriGene Technologies, Inc. | |||||||
TA338703 | Glutamate receptor 6 / GLUR6 antibody |
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Rabbit Polyclonal Anti-GRIK2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€360.00
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|
OriGene Technologies, Inc. | |||||||
AP06141PU-N | Glutamate receptor 6 / GLUR6 (841-890) antibody |
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Rabbit | Aff - Purified | Hu | P, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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AP54977SU-N | Glutamate receptor 6 / GLUR6 (N-term) antibody |
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Rabbit | Serum | Hu | C, E, WB |
0.2 ml /
€400.00
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Acris Antibodies GmbH |
CRISPR
Catalog No. | Species | Donor Vector | |
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KN222369 | GRIK2 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN222369BN | GRIK2 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN222369LP | GRIK2 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN222369RB | GRIK2 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP322369 | Glutamate receptor 6 / GLUR6 (transcript variant 1) |
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Recombinant protein of human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 1 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
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OriGene Technologies, Inc. | |||||
TP323048 | Glutamate receptor 6 / GLUR6 (transcript variant 2) |
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Recombinant protein of human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 2 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
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|
OriGene Technologies, Inc. | |||||
Human Lenti ORF Particles
Catalog No. | ||
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RC222369L2V | Lenti ORF particles, GRIK2 (mGFP-tagged) - Human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 1, 200 uL, >10^7 TU/mL |
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200 µl /
€1,957.00
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OriGene Technologies, Inc. | ||
RC223048L2V | Lenti ORF particles, GRIK2 (mGFP-tagged) - Human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 2, 200 uL, >10^7 TU/mL |
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200 µl /
€1,896.00
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OriGene Technologies, Inc. | ||
RC222369L1V | Lenti ORF particles, GRIK2 (Myc-DDK tagged) - Human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 1 , 200 uL, >10^7 TU/mL |
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200 µl /
€1,762.00
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OriGene Technologies, Inc. | ||
RC223048L1V | Lenti ORF particles, GRIK2 (Myc-DDK tagged) - Human glutamate receptor, ionotropic, kainate 2 (GRIK2), transcript variant 2 , 200 uL, >10^7 TU/mL |
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200 µl /
€1,710.00
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OriGene Technologies, Inc. | ||
Rat Lenti ORF Particles
Catalog No. | ||
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RR213098L2V | Lenti ORF particles, Grik2 (GFP-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 2 (Grik2), 200 uL, >10^7 TU/mL |
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200 µl /
€1,710.00
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OriGene Technologies, Inc. | ||
RR213098L1V | Lenti ORF particles, Grik2 (Myc-DDK-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 2 (Grik2), 200 uL, >10^7 TU/mL |
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200 µl /
€1,536.00
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OriGene Technologies, Inc. | ||