Glutamate receptor KA1 / GRIK4 antibody

Principal name

Glutamate receptor KA1 / GRIK4 antibody

Alternative names for Glutamate receptor KA1 / GRIK4 antibody

Excitatory amino acid receptor 1, EAA1, Glutamate receptor ionotropic kainate 4

SwissProt ID

Q01812 (Rat), Q16099 (Human), Q8BMF5 (Mouse)

Gene ID

2900 (GRIK4), 2900656 (Q6BVB2), 24406 (Grik4)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of Glutamate receptor KA1 / GRIK4 antibody

Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS). Glutamate is involved in cognitive functions like learning and memory in the brain. Imbalances in glutamatergic transmission have profound physiological and behavioral consequences. Ionotropic glutamate receptors are classified functiolly and by molecular homology into three receptor classes: N-methyl-D-aspartate (NMDA), amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kaite (KA). KA receptors assemble as tetramers from five subunit types, GluK1, GluK2 GluK3, GluK4 and GluK5. The GluK1-GluK3 subunits have low glutamate affinity and are capable of forming functiol homomeric channels. GluK4 and GluK5 are high-affinity kaite receptor subunits that bind glutamate but require coassembly with one or more GluK1-GluK3 subunits to form functiol channels. The heteromultimeric assembly of kaite receptors like many other ion channels leads to the formation of receptors with unique pharmacological and functiol properties. Unlike the other KA receptor subunits, which are expressed throughout the CNS, GluK4 expression is limited to only a few regions of the brain, and expression is highest in the CA3 region of the hippocampus and dentate gyrus. The GluK4 receptor subunit gene, GRIK4, is located near the tip of the long arm of chromosome 11. Genetic variants in the GRIK4 gene have been demonstrated to associate with several psychiatric disorders. GRIK4 has been identified as a susceptibility gene in schizophrenia and bipolar disorder. GluK4 may also play a role in excitotoxic Neurodegeneration.

General readings

Kamboj, R.K., et al., (1994) J. Neurochem. 62:1-9.

16 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor KA1 / GRIK4 (C-term) antibody

Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 (N-term) antibody

Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1,2. Anti-Kainate Receptor GluK4 (extracellular) antibody, (1:400). 3,4. Anti-Kainate Receptor GluK4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 (C-term) antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with GRIK4 antibody AP22667PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Glutamate receptor KA1 / GRIK4 Control Peptide

Glutamate receptor KA1 / GRIK4
50 µg / €160.00
  Acris Antibodies GmbH

Glutamate receptor KA1 / GRIK4 Control Peptide

Glutamate receptor KA1 / GRIK4
50 µg / €160.00
  Acris Antibodies GmbH

Glutamate receptor KA1 / GRIK4 antibody

Glutamate receptor KA1 / GRIK4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Glutamate receptor KA1 / GRIK4 antibody

Immunohistochemical staining of human brain tissue using GRIK4 polyclonal antibody ( Cat # PAB13313 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Glutamate receptor KA1 / GRIK4 antibody

Immunohistochemical staining of human brain tissue using GRIK4 polyclonal antibody ( Cat # PAB13314 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Glutamate receptor KA1 / GRIK4 antibody

Glutamate receptor KA1 / GRIK4 Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

Glutamate receptor KA1 / GRIK4 antibody

Glutamate receptor KA1 / GRIK4 Rabbit Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Glutamate receptor KA1 / GRIK4 antibody

Immunohistochemistry-Paraffin: Glutamate receptor KA1 Antibody [NBP1-76851] - Human brain tissue using Grik4 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Glutamate receptor KA1 / GRIK4 antibody

Immunohistochemistry-Paraffin: Glutamate receptor KA1 Antibody [NBP1-76852] - Human brain tissue using Grik4 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Glutamate receptor KA1 / GRIK4

Glutamate receptor KA1 / GRIK4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Glutamate receptor KA1 / GRIK4

Glutamate receptor KA1 / GRIK4 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GRIK4 overexpression lysate

GRIK4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

16 Item(s)

per page
  • LinkedIn