Glutamate receptor KA1 / GRIK4 antibody

Principal name

Glutamate receptor KA1 / GRIK4 antibody

Alternative names for Glutamate receptor KA1 / GRIK4 antibody

Excitatory amino acid receptor 1, EAA1, Glutamate receptor ionotropic kainate 4

SwissProt ID

Q01812 (Rat), Q16099 (Human), Q8BMF5 (Mouse)

Gene ID

2900 (GRIK4), 24406 (Grik4), 110637

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Glutamate receptor KA1 / GRIK4 antibody

Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS). Glutamate is involved in cognitive functions like learning and memory in the brain. Imbalances in glutamatergic transmission have profound physiological and behavioral consequences. Ionotropic glutamate receptors are classified functiolly and by molecular homology into three receptor classes: N-methyl-D-aspartate (NMDA), amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kaite (KA). KA receptors assemble as tetramers from five subunit types, GluK1, GluK2 GluK3, GluK4 and GluK5. The GluK1-GluK3 subunits have low glutamate affinity and are capable of forming functiol homomeric channels. GluK4 and GluK5 are high-affinity kaite receptor subunits that bind glutamate but require coassembly with one or more GluK1-GluK3 subunits to form functiol channels. The heteromultimeric assembly of kaite receptors like many other ion channels leads to the formation of receptors with unique pharmacological and functiol properties. Unlike the other KA receptor subunits, which are expressed throughout the CNS, GluK4 expression is limited to only a few regions of the brain, and expression is highest in the CA3 region of the hippocampus and dentate gyrus. The GluK4 receptor subunit gene, GRIK4, is located near the tip of the long arm of chromosome 11. Genetic variants in the GRIK4 gene have been demonstrated to associate with several psychiatric disorders. GRIK4 has been identified as a susceptibility gene in schizophrenia and bipolar disorder. GluK4 may also play a role in excitotoxic Neurodegeneration.

General readings

Kamboj, R.K., et al., (1994) J. Neurochem. 62:1-9.

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glutamate receptor KA1 / GRIK4 (C-term) antibody

  Rabbit Polyclonal Grik4 Antibody  
Western blot analysis of Grik4 in rat brain lysate with Grik4 antibody at (A) 0.5 (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 (N-term) antibody

  Rabbit Polyclonal Grik4 Antibody  
Western blot analysis of Grik4 in Rat brain tissue lysate with Grik4 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 antibody

  Rabbit Polyclonal Anti-Kainate Receptor GluK4 (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1,2. Anti-Kainate Receptor GluK4 (extracellular) antibody, (1:400). 3,4. Anti-Kainate Receptor GluK4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glutamate receptor KA1 / GRIK4 (C-term) antibody

Human Adrenal (formalin-fixed, paraffin-embedded) stained with GRIK4 antibody AP22667PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GRIK4 - human gene knockout kit via CRISPR

GRIK4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRIK4 - human gene knockout kit via CRISPR

GRIK4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIK4 - human gene knockout kit via CRISPR

GRIK4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIK4 - human gene knockout kit via CRISPR

GRIK4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grik4 - mouse gene knockout kit via CRISPR

Grik4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Grik4 - mouse gene knockout kit via CRISPR

Grik4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grik4 - mouse gene knockout kit via CRISPR

Grik4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grik4 - mouse gene knockout kit via CRISPR

Grik4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GRIK4 overexpression lysate

GRIK4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRIK4 (mGFP-tagged) - Human glutamate receptor, ionotropic, kainate 4 (GRIK4), 200 uL, >10^7 TU/mL

Lenti ORF particles, GRIK4 (mGFP-tagged) - Human glutamate receptor, ionotropic, kainate 4 (GRIK4), 200 uL, >10^7 TU/mL  
200 µl / €1,980.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRIK4 (Myc-DDK tagged) - Human glutamate receptor, ionotropic, kainate 4 (GRIK4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRIK4 (Myc-DDK tagged) - Human glutamate receptor, ionotropic, kainate 4 (GRIK4) , 200 uL, >10^7 TU/mL  
200 µl / €1,780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grik4 (GFP-tagged) - Mouse glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grik4 (GFP-tagged) - Mouse glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL  
200 µl / €1,720.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grik4 (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grik4 (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL  
200 µl / €1,550.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grik4 (GFP-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grik4 (GFP-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL  
200 µl / €1,720.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grik4 (Myc-DDK-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grik4 (Myc-DDK-tagged ORF) - Rat glutamate receptor, ionotropic, kainate 4 (Grik4), 200 uL, >10^7 TU/mL  
200 µl / €1,548.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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