Glycine decarboxylase / GLDC antibody

Principal name

Glycine decarboxylase / GLDC antibody

Alternative names for Glycine decarboxylase / GLDC antibody

GCSP, Glycine cleavage system P protein, Glycine decarboxylase, Glycine dehydrogenase (aminomethyl-transferring), Glycine dehydrogenase (decarboxylating), mitochondrial

Gene ID

2731 (GLDC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Xen (Xenopus)

Available hosts


Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Glycine decarboxylase / GLDC antibody

The glycine cleavage system is comprised of AMT (known as Protein T), GCSH (known as Protein H), DLD (known as Protein L) and GLDC (known as Protein P), all of which work together to catalyze the cleavage and degradation of glycine. GLDC (glycine dehydrogenase ), also known as GCE, GCSP (glycine cleavage system P protein) or HYGN1, is a 1,020 amino acid protein that localizes to the mitochondria and belongs to the gcvP family. GLDC binds to glycine and enables the methylamine group from glycine to be transferred to the Protein T. GLDC exists as a homodimer and utilizes pyridoxal phosphate as a cofactor. Mutations in the gene encoding GLDC leads to nonketotic hyperglycinemia (NKH), also known as glycine encephalopathy (GCE), an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

General readings

Chang, C.Y., et al. Acta Paediatr Taiwan 49(1):35-37(2008)
Kanno, J., et al. J. Med. Genet. 44 (3), E69 (2007)
Kure, S., et al. Hum. Mutat. 27(4):343-352(2006)

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glycine decarboxylase / GLDC antibody

Glycine dehydrogenase antibody detects Glycine dehydrogenase protein by western blot analysis. A. 30 ug HeLa whole cell lysate/extract. B. 30 ug HepG2 whole cell lysate/extract. 5 % SDS-PAGE. Glycine dehydrogenase antibody (TA308885) dilution: 1:500 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine decarboxylase / GLDC (N-term) antibody

Western blot analysis of GLDC Antibody (N-term) Cat.-No AP51849PU-N in mouse liver tissue lysates (35ug/lane). GLDC (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Glycine decarboxylase / GLDC antibody

Immunohistochemistry-Paraffin: GLDC Antibody [NBP1-83374] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.


Catalog No.    

GLDC overexpression lysate

GLDC overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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