Glycine receptor alpha-1 antibody

Principal name

Glycine receptor alpha-1 antibody

Alternative names for Glycine receptor alpha-1 antibody

GLRA1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit

SwissProt ID

P07727 (Rat), P23415 (Human), P57695 (Bovin), Q64018 (Mouse)

Gene ID

2741 (GLRA1), 25674 (Glra1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Dot blot (Dot)

Background of Glycine receptor alpha-1 antibody

Glycine receptors (GlyRs) mediate ionotropic inhibitory neurotransmission in the CNS where they play an essential role in inhibition of motor neurons in the spil cord and brainstem. The glycine receptor is composed of three ligand-binding subunits of 48 kDa (a) and two homologous polypeptides of 58 kDa (Ã?) that span the postsyptic membrane in a pentameric arrangement to form a Cl--selective channel. So far, at least three different a-subunit variants of the GlyR have been identified: a1, a2 and a33. Homo-oligomeric a2 receptors have a low strychnine-binding affinity and are considered to represent a neotal form of GlyR, which is replaced during development by receptors containing the a1 subunit. Adult GlyRs are predomintly composed of a1 and Ã? subunits, the a3 subunit being expressed at low levels in only a few brain regions.GlyRa1 subunits are widely expressed and contribute to many processes in the CNS, including inflammatory pain perception, modulation of auditory and visual pathways, and neurotransmission in the cerebellar cortex.Mutations in glycine receptor a1 subunits cause human hereditary hyperekplexia, a disorder characterized by an exaggerated startle response, which is a consequence of the role of GlyRs in motor reflex circuits of the spil cord.

General readings

Schofield,C.M., et al., (2004) Biochemistry 43 (31), 10058-10063

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glycine receptor alpha-1 (alpha-1/2) (N-term) antibody

  Rabbit Anti-Glycine Receptor Antibody  
Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~78k synapsin I doublet protein. Rabbit IgG Aff - Purified Hu, Ms, Rt C, Dot, WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 (Intracellular) antibody

Staining of Mouse Testis lysate using AP32151PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Glycine receptor alpha-1 antibody

  Anti-GLRA1/GLRA2/GLRA3 Rabbit Polyclonal Antibody  
Gel: 8%SDS-PAGE, Lysate: 40µg, Lane: Human placenta tissue, Primary antibody: TA321076(GLRA1 Antibody) at dilution 1/350 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

  Anti-GLRA1 Rabbit Polyclonal Antibody  
Predicted band size: 53 kDa . Positive control: Raji cell and mouse brain tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: Raji cell lysate Lane2: Mouse brain tissue lysate Lysates: 40 ug per lane Primary antibody: 1/260 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

  Anti-GLRA1 Rabbit Polyclonal Antibody  
Predicted band size: 53 kDa . Positive control: Mouse brain and human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Mouse brain tissue lysate Lane2: Human fetal brain tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

  Rabbit anti-GLRA1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using GLRA1 antibody. (1: Hela cell lysate 2: Mouse brain tissue lysate) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

  Rabbit Polyclonal Anti-Glycine Receptor Alpha1  
Western blot analysis of rat DRG (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat brain (lanes 3 and 6): 1-3. Anti-Glycine Receptor a1 antibody, (1:400). 4-6. Anti-Glycine Receptor a1 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

  Rabbit Polyclonal Anti-GLRA1 Antibody  
WB Suggested Anti-GLRA1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Raji cell lysateGLRA1 is supported by BioGPS gene expression data to be expressed in Raji Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

GLRA1 - human gene knockout kit via CRISPR

GLRA1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GLRA1 - human gene knockout kit via CRISPR

GLRA1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GLRA1 - human gene knockout kit via CRISPR

GLRA1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GLRA1 - human gene knockout kit via CRISPR

GLRA1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GLRA1 overexpression lysate

GLRA1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GLRA1 (mGFP-tagged)-Human glycine receptor, alpha 1 (GLRA1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GLRA1 (mGFP-tagged)-Human glycine receptor, alpha 1 (GLRA1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GLRA1 (mGFP-tagged) - Human glycine receptor, alpha 1 (GLRA1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, GLRA1 (mGFP-tagged) - Human glycine receptor, alpha 1 (GLRA1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GLRA1 (Myc-DDK-tagged)-Human glycine receptor, alpha 1 (GLRA1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, GLRA1 (Myc-DDK-tagged)-Human glycine receptor, alpha 1 (GLRA1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, GLRA1 (Myc-DDK tagged) - Human glycine receptor, alpha 1 (GLRA1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, GLRA1 (Myc-DDK tagged) - Human glycine receptor, alpha 1 (GLRA1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Glra1 (GFP-tagged ORF) - Rat glycine receptor, alpha 1 (Glra1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glra1 (GFP-tagged ORF) - Rat glycine receptor, alpha 1 (Glra1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, Glra1 (Myc-DDK-tagged ORF) - Rat glycine receptor, alpha 1 (Glra1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Glra1 (Myc-DDK-tagged ORF) - Rat glycine receptor, alpha 1 (Glra1), 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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