Glycine receptor alpha-1 antibody

Principal name

Glycine receptor alpha-1 antibody

Alternative names for Glycine receptor alpha-1 antibody

GLRA1, Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit

SwissProt ID

P07727 (Rat), P23415 (Human), P57695 (Bovin), Q64018 (Mouse)

Gene ID

2741 (GLRA1), 25674 (Glra1), 14654

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ze (Zebrafish), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Dot blot (Dot)

Background of Glycine receptor alpha-1 antibody

Glycine receptors (GlyRs) mediate ionotropic inhibitory neurotransmission in the CNS where they play an essential role in inhibition of motor neurons in the spil cord and brainstem. The glycine receptor is composed of three ligand-binding subunits of 48 kDa (a) and two homologous polypeptides of 58 kDa (Ã?) that span the postsyptic membrane in a pentameric arrangement to form a Cl--selective channel. So far, at least three different a-subunit variants of the GlyR have been identified: a1, a2 and a33. Homo-oligomeric a2 receptors have a low strychnine-binding affinity and are considered to represent a neotal form of GlyR, which is replaced during development by receptors containing the a1 subunit. Adult GlyRs are predomintly composed of a1 and Ã? subunits, the a3 subunit being expressed at low levels in only a few brain regions.GlyRa1 subunits are widely expressed and contribute to many processes in the CNS, including inflammatory pain perception, modulation of auditory and visual pathways, and neurotransmission in the cerebellar cortex.Mutations in glycine receptor a1 subunits cause human hereditary hyperekplexia, a disorder characterized by an exaggerated startle response, which is a consequence of the role of GlyRs in motor reflex circuits of the spil cord.

General readings

Schofield,C.M., et al., (2004) Biochemistry 43 (31), 10058-10063

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glycine receptor alpha-1 (alpha-1/2) (N-term) antibody

Western blot of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~78k synapsin I doublet protein. Rabbit IgG Aff - Purified Hu, Ms, Rt C, Dot, WB
0.2 mg / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 (Intracellular) antibody

Staining of Mouse Testis lysate using AP32151PU-N at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Glycine receptor alpha-1 antibody

Gel: 8%SDS-PAGE, Lysate: 40µg, Lane: Human placenta tissue, Primary antibody: TA321076(GLRA1 Antibody) at dilution 1/350 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

Predicted band size: 53 kDa . Positive control: Raji cell and mouse brain tissue lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: Raji cell lysate Lane2: Mouse brain tissue lysate Lysates: 40 ug per lane Primary antibody: 1/260 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 seconds) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

Predicted band size: 53 kDa . Positive control: Mouse brain and human fetal brain tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: Mouse brain tissue lysate Lane2: Human fetal brain tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

Western blot analysis of extracts of various cell lines, using GLRA1 antibody. (1: Hela cell lysate 2: Mouse brain tissue lysate) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

Western blot analysis of rat DRG (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat brain (lanes 3 and 6): 1-3. Anti-Glycine Receptor a1 antibody, (1:400). 4-6. Anti-Glycine Receptor a1 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

WB Suggested Anti-GLRA1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Raji cell lysateGLRA1 is supported by BioGPS gene expression data to be expressed in Raji Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Glycine receptor alpha-1 antibody

Western Blot analysis of GLRA1 expression in transfected 293T cell line (H00002741-T02) by GLRA1 MaxPab polyclonal antibody.

Lane 1: GLRA1 transfected lysate(51.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Western Blot analysis of GLRA1 expression in transfected 293T cell line by GLRA1 monoclonal antibody (M01), clone 2E6.

Lane 1: GLRA1 transfected lysate(51.7 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 2E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Western Blot analysis of GLRA1 expression in transfected 293T cell line by GLRA1 monoclonal antibody (M02), clone 2E7.

Lane 1: GLRA1 transfected lysate(51.7 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 2E7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 2G4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 3F1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Glycine receptor alpha-1 Mouse IgG2b 4D9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 3G8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 1F9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Detection limit for recombinant GST tagged GLRA1 is approximately 0.1ng/ml as a capture antibody. Mouse IgG2a 4D6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Western blot of rat spinal cord showing specific immunolabeling of the ~48k alpha1- and alpha2 subunits of the glycine receptor. The labeling was absent from a rat hippocampal (hipp) lysate as the glycine receptor is not expressed in the hippocampus. Rabbit Hu, Ms, Rt C, WB
0.2 mg / €470.00
  Abnova Taiwan Corp.

Glycine receptor alpha-1 antibody

Human Raji; WB Suggested Anti-GLRA1 Antibody Titration: 0.2-1 ug/ml. Positive Control: Raji cell lysate. GLRA1 is supported by BioGPS gene expression data to be expressed in Raji.; GLRA1 antibody - middle region (AVARP13003_P050) in Human Raji cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

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