Glycoprotein hormones alpha chain antibody

Principal name

Glycoprotein hormones alpha chain antibody

Alternative names for Glycoprotein hormones alpha chain antibody

Follitropin alpha chain, Follicle-stimulating hormone alpha chain, FSH-alpha, Lutropin alpha chain, Luteinizing hormone alpha chain, LSH-alpha, LH alpha, Thyrotropin alpha chain, Thyroid-stimulating hormone alpha chain, TSH-alpha, Choriogonadotropin alpha chain, Chorionic gonadotrophin subunit alpha, hCG-alpha, Anterior pituitary glycoprotein hormones common subunit alpha

SwissProt ID

P01215 (Human), P01216 (Mouse), P01217 (Bovin), P01218 (Sheep), P01219 (Pig), P01220 (Horse), P11962 (Rat)

Gene ID

1081 (CGA), 12640 (Cga)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), ELISA (capture) (E(capture)), Paraffin Sections (P), ELISA (detection) (E(detection)), Radioimmunoassay (R), Immunoprecipitation (IP), Frozen Sections (C), Western blot / Immunoblot (WB), Lateral Flow (LF)

Background of Glycoprotein hormones alpha chain antibody

Thyroid stimulating hormone (TSH), also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones.
TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity. 
TSH has a alpha subunit that is identical to the one in other glycoprotein hormones such as LH, FSH and HCG.

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