Glypican-2 antibody

Principal name

Glypican-2 antibody

Alternative names for Glypican-2 antibody

GPC2

Gene ID

221914 (GPC2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Glypican-2 antibody

The glypicans (GPC) constitute a family of heparan sulfate proteoglycans that are attached to the cell surface by a lycosylphosphatidylinositol (GPI) anchor. Six members of this family have been identified in mammals (GPC1-GPC6).
All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine rich domain (CRD) with 14 invariant cysteine residues, a stalklike region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site. Based on the degree of their amino acid sequence similarity, two subfamilies of glypicans have been defined. One subfamily (sharing from 35-63% sequence homology) includes GPC1, 2, 4, and 6, while the second subfamily (sharing 54% sequence identity) includes GPC3 and 5. Proteins between the two subfamilies also share 17-25% sequence similarity (1-4).
Glypicans are widely expressed in adult and fetal tissues. During embryonic development, the expression level of the various glypicans changes in a stage and tissue specific manner. GPC2, also known as cerebroglycan, is primarily expressed in developing neuronal tissues including the brain, spinal cord, dorsal root ganglia, and cranial nerves. It is found on the tracts of actively growing axons (5). Cell surface GPC2 binds midkine, indicating midkine GPC2 interaction may participate in neuronal cell migration and neurite outgrowth (6).

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Glypican-2 antibody

WB Suggested Anti-GPC2 Antibody; Titration: 1.0 ug/ml; Positive Control: HCT15 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Glypican-2 (N-term) antibody

Western blot analysis of GPC2 Antibody (N-term) Cat.-No AP51901PU-N in T47D cell line lysates (35 µg/lane). This demonstrates the GPC2 antibody detected the GPC2 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Glypican-2 antibody

Glypican-2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GPC2 overexpression lysate

GPC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
  • LinkedIn