GNAS / GSP antibody

Principal name

GNAS / GSP antibody

Alternative names for GNAS / GSP antibody

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Adenylate cyclase-stimulating G alpha protein

SwissProt ID

P04896 (Bovin), P63092 (Human), P63094 (Mouse), P63095 (Rat)

Gene ID

2778 (GNAS), 281793

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of GNAS / GSP antibody

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5\' exons. Some transcripts contains a differentially methylated region (DMR) at their 5\' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

General readings

Bagchi,G., (2008) Cancer Res. 68 (9), 3225-3231

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GNAS / GSP antibody

Human Pancreas; Rabbit Anti-GNAS Antibody. Catalog Number: arp42693. Paraffin Embedded Tissue: Human Pancreas. Antibody Concentration: 5 ug/ml; GNAS antibody - N-terminal region (ARP42693_P050) in Human Pancreas cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

GNAS / GSP antibody

(1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GNAS / GSP antibody

Adult rat brain membrane immunoblot Mouse IgG1 N192/12 Supernatant Ms, Rt WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

GNAS / GSP antibody

Adult rat brain membrane immunoblot Mouse IgG1 N192/12 Purified Ms, Rt WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

GNAS / GSP antibody

GNAS / GSP Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

GNAS / GSP antibody

Western Blot: G protein alpha Antibody [NBP1-58349] - This Anti-GNAS antibody was used in Western Blot of MCF7 tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GNAS / GSP (transcript variant 1)

GNAS / GSP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

GNAS / GSP (transcript variant 3)

GNAS / GSP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

GNAS / GSP (transcript variant 7)

GNAS / GSP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

GNAS overexpression lysate

GNAS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GNAS overexpression lysate

GNAS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GNAS overexpression lysate

GNAS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GNAS overexpression lysate

GNAS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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