GNAS1 / XLalphas antibody

Principal name

GNAS1 / XLalphas antibody

Alternative names for GNAS1 / XLalphas antibody

Extra large alphas protein, G protein alpha XLas, Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Adenylate cyclase-stimulating G alpha protein

SwissProt ID

Q5JWF2 (Human), Q63803 (Rat), Q6R0H7 (Mouse)

Gene ID

2778 (GNAS)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Chk (Chicken), African clawed frog, Mky (Monkey), Prim (Primate)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of GNAS1 / XLalphas antibody

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5\' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5\' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance. There are RefSeqs representing four transcript variants of this gene. Other transcript variants including four additional exons have been described; however, their full length sequences have not been determined.This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5\' exons. Some transcripts contains a differentially methylated region (DMR) at their 5\' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript exists, and this antisense transcript and one of the transcripts are paternally expressed, produce noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

General readings

Linglart,A., (2006) Endocrinology 147 (5), 2253-2262

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GNAS1 / XLalphas antibody

Human Lung; GNAS antibody - N-terminal region (ARP42694_T100) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

GNAS1 / XLalphas (385-394) antibody

Anti-GNAS antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. Rabbit Purified Hu, Mky, Prim E, P
50 µg / €345.00
  OriGene Technologies, Inc.

GNAS1 / XLalphas antibody

Western blot analysis of GNAS Antibody (Center) (AP17431PU-N) in Ramos cell line lysates (35 µg/lane). GNAS (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GNAS1 / XLalphas (164-394) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

GNAS1 / XLalphas antibody

human thryoid; . Sample Type:.  Nthy-ori cell lysate (50ug). Primary Dilution:.  1:1000. Secondary Antibody:.  anti-rabbit HRP. Secondary Dilution: . 1:2000. Image Submitted By:.  Anonymous.; GNAS antibody - N-terminal region (ARP41764_T100) in human thryoid cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

GNAS1 / XLalphas antibody

Human Jurkat; WB Suggested Anti-GNAS Antibody Titration: 2.5ug/ml. Positive Control: Jurkat cell lysate. There is BioGPS gene expression data showing that GNAS is expressed in Jurkat.; GNAS antibody - C-terminal region (ARP41765_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

6 Item(s)

per page
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