GNRH1 / Progonadoliberin-1 antibody

Principal name

GNRH1 / Progonadoliberin-1 antibody

Alternative names for GNRH1 / Progonadoliberin-1 antibody

GNRH, GRH, LHRH, GnRH-associated peptide 1

SwissProt ID

O54713 (Cavpo), P01148 (Human), P07490 (Rat), P13562 (Mouse), P37042 (Chick), P45656 (Xenla), P49921 (Pig)

Gene ID

2796 (GNRH1), 2798 (GNRHR), 14714 (Gnrh1)

Available reactivities

Ms (Mouse), Mam (Mammalia), Hu (Human), Rt (Rat), Hst (Hamster), Mky (Monkey), Chk (Chicken), Fi (Fish), Rb (Rabbit), Sh (Sheep), Gt (Goat)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Radioimmunoassay (R), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of GNRH1 / Progonadoliberin-1 antibody

Gonadotropin releasing hormone (GnRH), also known as luteinizing hormone releasing hormone (LHRH), is a key molecule in the regulation of reproduction in vertebrates. GnRH, a decapeptide, is produced by neurons in the medial basal hypothalamus (MBH) and secreted in a pulsatile manner into the cardiovascular system. The frequency and amplitude of GnRH pulses determine secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary. Higher frequencies (greater than one pulse per hour) stimulate LH secretion while lower frequencies stimulate FSH secretion. The generation of GnRH pulses is effected by numerous stimuli, such as neural, hormonal and environmental. Therefore, behavioral and physiological conditions such as sleep, exercise, and stress can affect the GnRH pulses and cause a disruption of the normal cycle.
Recent studies show that GnRH also has a role in mediating cancer. GnRH has been shown to inhibit the growth of human uterine leiomyloma cells by suppressing proliferation and inducing apoptosis. GnRH analogs have been used to treat a wide variety of reproductive cancers, although the side effects of using such compounds are often quite severe.

General readings

Norwitz ER et al. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology 143:985-97 (2002). PubMed PMID: 11861523
Kennedy SR et al. Growth hormone response to a novel growth hormone-releasing tripeptide in horses: interaction with gonadotropin-releasing hormone, thyrotropin-releasing hormone, and sulpiride. J Anim Sci 80:744-50 (2002). PubMed PMID: 11890411

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GnRH antibody

GnRH Rabbit Purified Hu, Rt P, WB
50 µl / €480.00
  Acris Antibodies GmbH

GnRH antibody

GnRH Rabbit Serum Hu C, ICC/IF, P
0.25 ml / €250.00
  Acris Antibodies GmbH

GnRH antibody

GnRH Rabbit Serum Hu C, E, P, R
0.25 ml / €320.00
  Acris Antibodies GmbH

GnRH antibody

Staining with LHRH (Luteinizing Hormone Releasing Hormone) Antibody 20075 Rabbit Serum Mam C, ICC/IF
0.1 ml / €370.00
  ImmunoStar Inc.

GnRH antibody

Figure 1 shows immunlocalization of GnRH in mouse embryo brain using NB 300-506. Rabbit Purified Hu, Ms ICC/IF, P
0.1 ml / €400.00
  Novus Biologicals Inc.

GNRH1 / Progonadoliberin-1 antibody

Western blot analysis of extracts of Recombinant Protein cell line, using GNRH1 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

GNRH1 / Progonadoliberin-1 (11-60) antibody

Immunohistochemistry (IHC) analysis of GnRH 1 Antibody Cat.-No AP33395PU-N  in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GNRH1 / Progonadoliberin-1 antibody

GNRH1 / Progonadoliberin-1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1 antibody

GNRH1 / Progonadoliberin-1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1 antibody

GNRH1 / Progonadoliberin-1 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1 antibody

GNRH1 / Progonadoliberin-1 Mouse IgG2a 4H3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1 antibody

GNRH1 / Progonadoliberin-1 Mouse IgM 1C2 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1 antibody

Immunohistochemistry-Paraffin: GnRH Antibody [NBP1-89749] Immunohistochemical staining of human placenta shows moderate membranous positivity in trophoblasitc cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GNRH1 / Progonadoliberin-1 (transcript variant 2)

GNRH1 / Progonadoliberin-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

GNRH1 / Progonadoliberin-1 (24-92, His-tag)

GNRH1 / Progonadoliberin-1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €940.00
  Acris Antibodies GmbH

GNRH1 / Progonadoliberin-1 (24-92, His-tag)

GNRH1 / Progonadoliberin-1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

GNRH1 / Progonadoliberin-1

GNRH1 / Progonadoliberin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1

GNRH1 / Progonadoliberin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1

GNRH1 / Progonadoliberin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GNRH1 / Progonadoliberin-1

GNRH1 / Progonadoliberin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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