GPBAR1 / TGR5 antibody

Principal name

GPBAR1 / TGR5 antibody

Alternative names for GPBAR1 / TGR5 antibody

G-protein coupled bile acid receptor 1, BG37, G-protein coupled receptor GPCR19, M-BAR, Membrane-type receptor for bile acids

SwissProt ID

Q80SS6 (Mouse), Q80T02 (Rat), Q862A8 (Rabit), Q862A9 (Bovin), Q8TDU6 (Human)

Gene ID

151306 (GPBAR1)

Available reactivities

Hu (Human), Chimp (Chimpanzee), Eq (Equine), Mky (Monkey), Ms (Mouse), Prim (Primate), Rt (Rat), Rb (Rabbit)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of GPBAR1 / TGR5 antibody

The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPBAR1 / TGR5 (C-term) antibody

Anti-TGR5 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 (C-term) antibody

Anti-GPBAR1 / TGR5 antibody IHC of human colon, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hst, Hu, Mky, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 antibody

Immunofluorescence analysis of LOVO cells, using GPBAR antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 antibody

Western Blot: TGR5 Antibody [TA336956] - Western blot analysis of TGR5 in spleen lysate. Lane 1 shows pre-immune sera. Lane 2 shows TA336956 tested at 1:5000 on mouse spleen lysate. Rabbit Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 antibody

Western Blot: TGR5 Antibody [TA336958] - Western blot analysis of TGR5 in spleen lysate. Lane 1 shows pre-immune sera. Lanes 2, 3 and 4 show TA336958 tested on human (1:1000), mouse (1:5000) and rat (1:5000) spleen lysate, respectively. Rabbit Purified Hu, Ms, Prim, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 antibody

Western Blot: TGR5 Antibody [TA336959] - Analysis of TGR5 in spleen lysate.  Lane 1 shows pre-immune sera.  Lanes 2, 3 and 4 show TGR5 antibody tested on human (1:1000), mouse (1:5000) and rat (1:5000) spleen lysate, respectively. Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 antibody

Western Blot: TGR5 Antibody [TA337009] - Western blot analysis of TGR5 using TGR5 polyclonal antibody. Human kidney lysate in the 1) absence and 2) presence of immunizing peptide probed with TGR5 antibody at 3 ug/ml. Rabbit Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 (1st Cytopl. Dom.) antibody

Anti-TGR5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 (3rd cytopl. dom.) antibody

Human Uterus, Endometrium: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

GPBAR1 / TGR5 (302-322) antibody

Colon: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hst, Hu, Mky, Prim P, WB
50 µg / €470.00
  Acris Antibodies GmbH

GPBAR1 / TGR5 antibody

Immunofluorescence analysis of LOVO cells, using GPBAR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
50 µg / €205.00
  Assay Biotech

GPBAR1 / TGR5 antibody

Immunofluorescence analysis of LOVO cells, using GPBAR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF
0.1 mg / €310.00
  Assay Biotech

GPBAR1 / TGR5 antibody

Immunohistochemistry-Paraffin: GPCR TGR5 Antibody [NBP1-39749] - GPCR TGR5 antibody (10 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human colon, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Hu P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

GPBAR1 overexpression lysate

GPBAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GPBAR1 overexpression lysate

GPBAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GPBAR1 overexpression lysate

GPBAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GPBAR1 overexpression lysate

GPBAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

GPBAR1 overexpression lysate

GPBAR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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