GPNMB / HGFIN antibody

Principal name

GPNMB / HGFIN antibody

Alternative names for GPNMB / HGFIN antibody

Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN

SwissProt ID

Q14956 (Human), Q6P7C7 (Rat), Q99P91 (Mouse)

Gene ID

10457 (GPNMB), 93695 (Gpnmb)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), African clawed frog, Eq (Equine), Rb (Rabbit), GP (Guinea Pig)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of GPNMB / HGFIN antibody

Transmembrane glycoprotein NMB is a protein that in humans is encoded by the GPNMB gene. In osteoblast progenitor cells, GPNMB works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization that is mediated at least in part by BMP-2 in a SMAD1 dependent manner to promote osteoblast differentiation. GPNMB can enhance the repairing process in bone fracture, demonstrated by its high expression during chondrogenesis(soft callus) and osteogenesis(hard callus) compared to the intact femurs that is why Osteoactivin(OA) could be a novel therapeutic agent used to treat generalized osteoporosis or localized osteopenia during fracture repair by stimulating bone growth and regeneration. Similarly, GPNMB expression increases during osteoclast differentiation and it is functionally implicated in this process, possibly by promoting the fusion of osteoclast progenitor cells.

General readings

Rose A.A., et al. (2010) PLoS ONE. 5:e12093-e12093Patel-Chamberlin M., et al. (2011) Kidney Int. 79:1138-1148

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI2F9 (formerly 2F9)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807745)(1:150) Mouse IgG1 OTI2F9 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI2A10 (formerly 2A10)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-GPNMB mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807766)(1:150) Mouse IgG1 OTI2A10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  Rabbit Polyclonal Anti-GPNMB Antibody  
WB Suggested Anti-GPNMB Antibody Titration: 1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Ms, Por, Rb P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

GPNMB / HGFIN antibody

  Rabbit Polyclonal Anti-GPNMB Antibody  
WB Suggested Anti-GPNMB Antibody Titration: 1 ug/ml; Positive Control: 293T cells lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

GPNMB / HGFIN antibody

  Rabbit Polyclonal Anti-GPNMB Antibody  
WB Suggested Anti-GPNMB Antibody Titration: 0.2-1 ug/ml; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI1E3 (formerly 1E3)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPNMB (RC207615, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPNMB.(1:2000) Mouse IgG1 OTI1E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI1G10 (formerly 1G10)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPNMB (RC207615, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPNMB. Mouse IgG2a OTI1G10 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI8A10 (formerly 8A10)  
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-GPNMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807721) Mouse IgG2a OTI8A10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI5C2  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPNMB (RC207615, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPNMB.(1:2000) Mouse IgG1 OTI5C2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

  GPNMB mouse monoclonal antibody, clone OTI7E3  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GPNMB (RC207615, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-GPNMB.(1:2000) Mouse IgG1 OTI7E3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPNMB / HGFIN antibody

Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3A5 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GPNMB - human gene knockout kit via CRISPR

GPNMB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GPNMB - human gene knockout kit via CRISPR

GPNMB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GPNMB - human gene knockout kit via CRISPR

GPNMB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GPNMB - human gene knockout kit via CRISPR

GPNMB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gpnmb - mouse gene knockout kit via CRISPR

Gpnmb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Gpnmb - mouse gene knockout kit via CRISPR

Gpnmb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPNMB / HGFIN (transcript variant 1)

  Recombinant protein of human glycoprotein (transmembrane) nmb (GPNMB), transcript variant 1  
GPNMB / HGFIN Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

GPNMB / HGFIN (transcript variant 1)

  Recombinant protein of human glycoprotein (transmembrane) nmb (GPNMB), transcript variant 1  
GPNMB / HGFIN Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

GPNMB / HGFIN (22-474, His-tag)

GPNMB / HGFIN Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

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