GPR109A antibody

Principal name

GPR109A antibody

Alternative names for GPR109A antibody

HM74A, NIACR1, Niacin receptor 1, Nicotinic acid receptor, PUMA-G, Pumag, G-protein coupled receptor 109A, G-protein coupled receptor HM74A

SwissProt ID

Q80Z39 (Rat), Q8TDS4 (Human), Q9EP66 (Mouse)

Gene ID

338442 (HCAR2)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Rat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of GPR109A antibody

NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR109A (Center) antibody

Western blot analysis of GPR109A Antibody (Center) Cat.-No AP52875PU-N in NCI-H292 cell line lysates (35ug/lane). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GPR109A antibody

Immunohistochemistry-Paraffin: NIACR1 Antibody [NBP1-92180] Immunohistochemical staining of human thyroid gland shows strong granular cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPR109A

GPR109A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

HCAR2 overexpression lysate

HCAR2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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