GPR6 / LGR6 antibody

Principal name

GPR6 / LGR6 antibody

Alternative names for GPR6 / LGR6 antibody

G-protein coupled receptor 6, Leucine-rich repeat-containing G-protein coupled receptor 6

SwissProt ID

Q3UVD5 (Mouse), Q9HBX8 (Human)

Gene ID

59352 (LGR6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of GPR6 / LGR6 antibody

Relaxin family peptides which closely resembles insulin, act on a group of G-protein-coupled receptors now known as relaxin family peptide (RXFP) receptors. The leucine-rich repeat containing RXFP1 and RXFP2 and the small peptide-like RXFP3 and RXFP4 are the physiological targets for relaxin, insulin-like (INSL) peptide 3, relaxin-3 and INSL5, respectively. Leucine rich repeat containing GPCR (Lgr6) is a member of the same large family of GPCR (Lgr1-Lgr16) that binds to variety of glycoprotein hormones like TSH, FSH, LH (1). This family of receptor is unique in having a large ectodomain important for ligand binding. The large extracelluar domain binds the ligands with high affinity; there also exist a low affinity binding site in the exoloop of the trnasmembrane region. LGR6 has a subgroup-specific hinge region after leucine-rich repeats whereas LGR7, like snail LGR, contains a low density lipoprotein (LDL) receptor cysteine-rich motif at the N terminus. The expression of LGR5 is induced in the limb, tail, and intestine by T3 during metamorphosis of frog form larval stage. More importantly, LGR5 mRNA is localized to the developing adult epithelial stem cells of the intestine (2). Lgr6 are also involved in transcription silencing of CpG islands by hypermethylation in colorectal cancer which are referred as methylator phenotypes. The CAN genes include SYNE1, STRAD8, CD109, RNF, RET, APC2 MMP2, PTPRD and Lgr6 (3). Lgr5 is a marker for cycling stem cells in intestine (4) whereas Lgr6 is expressed in earliest embryonic hair placodes (5).Lgr6 positive cells are also involved in wound healing. In adult hair follicles the Lgr6 resides in a region just above the follicle bulge, this region was previously uncharacterized and does not express any known bulge stem cell markers. The Lgr6 is a marker for a distinct population of stem cells that give rise to all lineages of the skin. Unlike Lgr5, the Lgr6 is not regulated by Wnt signaling. The Lgr6-selective antibodies were generated against antigenic peptide taken from human Lgr6 protein corresponding near to carboxy terminal Lgr6 protein. Lgr6-antibodies are affinity purified over immobilized antigen based chromatography, and the purified immunoglobulins are stabilized in antibody stabilization buffer.

Items 1 to 20 of 22 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR6 / LGR6 antibody

Anti-LGR6 mouse monoclonal antibody (TA504757) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LGR6(RC219284). Mouse IgG1 OTI2A3 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

GPR6 / LGR6 antibody

Western blot analysis of extracts from HUVEC cells, using LGR6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPR6 / LGR6 (N-term) antibody

Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

GPR6 / LGR6 antibody

Anti-LGR6 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

GPR6 / LGR6 antibody

GPR6 / LGR6 Rabbit Serum Hu C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

GPR6 / LGR6 antibody

GPR6 / LGR6 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

GPR6 / LGR6 antibody

Immunofluorescence analysis of LOVO cells, using LGR6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

GPR6 / LGR6 antibody

Immunofluorescence analysis of LOVO cells, using LGR6 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

GPR6 / LGR6 antibody

Western blot analysis of LGR6 expression in L929 (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

GPR6 / LGR6 antibody

Western blot analysis of LGR6 expression in L929 (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

GPR6 / LGR6 antibody

Western blot analysis of LGR6 expression in L929 (A); mouse brain (B); rat kidney (C) whole cell lysates. Rabbit Aff - Purified Hu WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

GPR6 / LGR6 antibody

GPR6 / LGR6 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

GPR6 / LGR6 antibody

GPR6 / LGR6
0.25 mg / €340.00
  Novus Biologicals Inc.

GPR6 / LGR6 antibody

GPR6 / LGR6 Rabbit IgG FITC Hu, Rt E, WB
50 µg / €340.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPR6 / LGR6

GPR6 / LGR6 Human
10 µg / €540.00
  Abnova Taiwan Corp.

GPR6 / LGR6

GPR6 / LGR6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

GPR6 / LGR6

GPR6 / LGR6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

GPR6 / LGR6

GPR6 / LGR6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

GPR6 / LGR6

GPR6 / LGR6 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

LGR6 overexpression lysate

LGR6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Items 1 to 20 of 22 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn