GPR65 / Psychosine receptor antibody

Principal name

GPR65 / Psychosine receptor antibody

Alternative names for GPR65 / Psychosine receptor antibody

G-protein coupled receptor 65, TDAG8, T-cell death-associated protein 8

SwissProt ID

Q61038 (Mouse), Q8IYL9 (Human)

Gene ID

8477 (GPR65)

Available reactivities

Hu (Human), Mky (Monkey), Gorilla, Bt (Bat), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Rt (Rat), Bear

Available hosts

Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of GPR65 / Psychosine receptor antibody

GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1
GPR65 has been reported in human in peripheral blood leukocytes, spleen, lymph node, and thymus. ESTs have been isolated from human B-cell/lung/testis, brain/lung/testis, pancreas/spleen, lung/spleen, leukocyte, embryo, kidney, liver/spleen, thyroid, and vessel libraries.

General readings

Mogi, C., et al. J. Immunol. 182(5):3243-3251 (2009)
Ishii, S., et al. J. Biol. Chem. 280(10):9083-9087 (2005)
Radu, C.G., et al. Proc. Natl. Acad. Sci. U.S.A. 102(5):1632-1637 (2005)

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR65 / Psychosine receptor (1st cytopl. dom.) antibody

  GPR65 Rabbit Polyclonal (Cytoplasmic Domain) Antibody  
Anti-GPR65 / TDAG8 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

GPR65 / Psychosine receptor (3rd cytopl. dom.) antibody

  GPR65 Rabbit Polyclonal (Cytoplasmic Domain) Antibody  
Anti-GPR65 / TDAG8 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky, Prim, Rb P
50 µg / €400.00
  OriGene Technologies, Inc.

GPR65 / Psychosine receptor antibody

  GPR65 Rabbit Polyclonal (Extracellular Domain) Antibody  
Anti-GPR65 antibody IHC of human lymph node. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

GPR65 / Psychosine receptor antibody

  Rabbit Polyclonal TDAG8/GPR65 Antibody  
Western Blot: GPR65 Antibody [TA336983] - Analysis of human GPR65 in human kidney lysate in the 1) absence and 2) presence of immunizing peptide using GPR65 antibody at 1 ug/ml. Rabbit Purified Hu, Prim P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GPR65 / Psychosine receptor antibody

  Rabbit Polyclonal Anti-GPR65 Antibody  
GPR65 / Psychosine receptor Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPR65 / Psychosine receptor (C-term) antibody

Western blot analysis of GPR65 (arrow) in Hela cell line lysates (35ug/lane) using GPR65 / Psychosine receptor antibody Cat.-No. AP51930PU-N. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GPR65 - human gene knockout kit via CRISPR

GPR65 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GPR65 - human gene knockout kit via CRISPR

GPR65 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GPR65 - human gene knockout kit via CRISPR

GPR65 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GPR65 - human gene knockout kit via CRISPR

GPR65 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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