GPR73 / Prokineticin receptor 1 antibody

Principal name

GPR73 / Prokineticin receptor 1 antibody

Alternative names for GPR73 / Prokineticin receptor 1 antibody

PK-R1, PROKR1, PKR1, G-protein coupled receptor 73, ZAQ, GPR73a, G-protein coupled receptor ZAQ

SwissProt ID

Q8R416 (Rat), Q8SPN2 (Bovin), Q8TCW9 (Human), Q9JKL1 (Mouse)

Gene ID

10887 (PROKR1), 192648 (Prokr1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C)

Background of GPR73 / Prokineticin receptor 1 antibody

The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestil motility, angiogenesis, hematopoiesis and circadian rhythms regulation. The biological effects of the PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin Receptor 1 (PKR1) and Prokineticin Receptor 2 (PKR2) that belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency. PKR1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization. In addition, activation of the mitogen-activated protein kise (MAPK) pathways has also been described. PKR1 is broadly distributed throughout peripheral tissues including the intestil tract, testis, uterus, lung and peripheral blood leukocytes. In addition, the receptor is expressed in the brain particularly in olfactory regions as well as in dorsal root ganglion (DRG) neurons. The physiological function of PKR1 is still being elucidated, however, evidence suggest that the receptor has an important role in pain perception through its ability to stimulate the TRPV1 ion channel in DRG neurons. In addition, a role for PKR1 in the control of the inflammatory response through regulation of macrophage chemotaxis and cytokine production has also been demonstrated.3

General readings

Brouillet S, Hoffmann P, Chauvet S, Salomon A, Chamboredon S, Sergent F, Benharouga M, Feige JJ, Alfaidy N. Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors. Cell Mol Life Sci. 2011 Dec 3.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR73 / Prokineticin receptor 1 antibody

Western blot analysis of rat brain membranes: 1. Anti-Prokineticin Receptor 1 (extracellular) antibody , (1:200). 2. Anti-Prokineticin Receptor 1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GPR73 / Prokineticin receptor 1 antibody

Western blot analysis of extracts from COLO cells, using PKR1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPR73 / Prokineticin receptor 1 (C-term) antibody

Anti-PROKR1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Elephant, Eq, Hu, Mky, Op, Prim P
50 µg / €379.00
  OriGene Technologies, Inc.

GPR73 / Prokineticin receptor 1 antibody

Anti-PROKR1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky WB
50 µg / €379.00
  OriGene Technologies, Inc.

GPR73 / Prokineticin receptor 1 antibody

Immunocytochemical localization of PKR1 in fasciculata cells Rabbit Purified Hu C, E, F, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

GPR73 / Prokineticin receptor 1 antibody

Western blot analysis of extracts from COLO cells, using PKR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

GPR73 / Prokineticin receptor 1 antibody

Western blot analysis of extracts from COLO cells, using PKR1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPR73 / Prokineticin receptor 1

GPR73 / Prokineticin receptor 1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PROKR1 overexpression lysate

PROKR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

9 Item(s)

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