GPR73b / Prokineticin receptor 2 antibody

Principal name

GPR73b / Prokineticin receptor 2 antibody

Alternative names for GPR73b / Prokineticin receptor 2 antibody

PK-R2, G-protein coupled receptor 73-like 1, GPRg2, PROKR2, GPR73L1, PKR2

SwissProt ID

Q8K458 (Mouse), Q8NFJ6 (Human), Q8R415 (Rat), Q8SPN1 (Bovin)

Gene ID

246313 (Prokr2), 128674 (PROKR2), 192649

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Eq (Equine), Mky (Monkey), Prim (Primate), Bov (Bovine), Can (Canine)

Available hosts

Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of GPR73b / Prokineticin receptor 2 antibody

The Prokineticins (PK1 and PK2) are a pair of cysteine-rich secreted peptides with broad physiological functions including gastrointestil motility, angiogenesis, hematopoiesis and circadian rhythms regulation. The biological effects of the PK1 and PK2 are mediated by two highly homologous receptors termed Prokineticin Receptor 1 (PKR1) and Prokineticin Receptor 2 (PKR2) that belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. Both PK ligands activate the two PK receptors with similar potency. PKR2 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization. The distribution of PKR2 is relatively restricted with high expression levels in the brain, spil cord and dorsal root ganglions, in organs of the reproductive system and in endocrine tissues such as the thyroid, pituitary and adrel glands. The PK2 ligand has been shown to be involved in the regulation of circadian rhythms of physiological and behavioral processes in mammals, probably through sigling via PKR2 which is highly expressed in the suprachiasmatic nucleus (SCN), an area of the brain that controls circadian rhythm processes. In addition, loss of function mutations in the PKR2 gene have been associated with Kallmann Syndrome, a condition characterized by idiopathic hypogodotropic hypogodism (IHCCH) in combition with anosmia, a compromised sense of smell.

General readings

Brouillet S, Hoffmann P, Chauvet S, Salomon A, Chamboredon S, Sergent F, Benharouga M, Feige JJ, Alfaidy N. Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors. Cell Mol Life Sci. 2011 Dec 3.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR73b / Prokineticin receptor 2 antibody

  Goat Anti-PROKR2 Antibody  
(1ug/ml) staining of Rat Stomach lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 antibody

  Anti-PROKR2 Rabbit Polyclonal Antibody  
Predicted band size: 44 kDa . Positive control: 823 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 20 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 antibody

  Rabbit polyclonal Anti-Prokineticin Receptor-2 (extracellular)  
Western blot analysis of rat brain membranes: 1. Anti-Prokineticin Receptor 2 (extracellular) antibody , (1:200). 2. Anti-Prokineticin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 (N-term, Extracell. Dom.) antibody

  Rabbit Polyclonal Anti-PROKR2 Antibody (N-Terminus)  
Anti-PROKR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Eq, Hu, Mky, Prim P
50 µg / €400.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 (C-term) antibody

  Rabbit Polyclonal Anti-PROKR2 Antibody (C-Terminus)  
Anti-PROKR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Can, Eq, Hu, Mky, Prim, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 antibody

  Rabbit Polyclonal Anti-PROKR2 Antibody (N-Terminus)  
Anti-PROKR2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

GPR73b / Prokineticin receptor 2 antibody

GPR73b / Prokineticin receptor 2 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

GPR73b / Prokineticin receptor 2 antibody

Immunocytochemical localization of PKR2 in fasciculata cells Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PROKR2 - human gene knockout kit via CRISPR

PROKR2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PROKR2 - human gene knockout kit via CRISPR

PROKR2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROKR2 - human gene knockout kit via CRISPR

PROKR2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PROKR2 - human gene knockout kit via CRISPR

PROKR2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prokr2 - mouse gene knockout kit via CRISPR

Prokr2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Prokr2 - mouse gene knockout kit via CRISPR

Prokr2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prokr2 - mouse gene knockout kit via CRISPR

Prokr2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Prokr2 - mouse gene knockout kit via CRISPR

Prokr2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPR73b / Prokineticin receptor 2

  Recombinant protein of human prokineticin receptor 2 (PROKR2)  
GPR73b / Prokineticin receptor 2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PROKR2 overexpression lysate

PROKR2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Prokr2 (GFP-tagged) - Mouse prokineticin receptor 2 (Prokr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Prokr2 (GFP-tagged) - Mouse prokineticin receptor 2 (Prokr2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Prokr2 (Myc-DDK-tagged) - Mouse prokineticin receptor 2 (Prokr2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Prokr2 (Myc-DDK-tagged) - Mouse prokineticin receptor 2 (Prokr2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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