GPR78 antibody

Principal name

GPR78 antibody

Alternative names for GPR78 antibody

G-protein coupled receptor 78

SwissProt ID

Q96P69 (Human)

Gene ID

27201 (GPR78)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of GPR78 antibody

Within the ER misfolded proteins are detected by Bip(GPR78). In the presence of misfolded proteins, Bip disscociates from PERK, allowing it to homodimerize and autophosphoyate. In its dimerized, phosphorylated form PERK phosphorylates eIF2. The phosphorylation of eIF2 blocks the majority of translation to prevent the continued accumulation of protein in the ER. Bip also is binds to IRE1 and ATF6 under normal ER conditions, but dissociates upon accumulation of misfolded proteins. Unbound ATF6 is translocated to the gogli where it is converted into a cleaved, active form. The cleaved form of ATF6 is then able to up regulated transcription of UPR genes including XBP1. Activated IRE1 acts as an endoribonuclease to an intron from XBP1 transcripts. The XBP1 splice variant codes for an active transcription factor which activates transcription of P58IPK. P58IPK is a HSP40 protein which binds to and inhibits PERK. Thus, if the accumulated, misfolded proteins have been removed, P58IPK acts to shut down the UPR by removing the block to translation

8 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GPR78 (C-term) antibody

Anti-GPR78 antibody IHC of human placenta, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Gorilla, Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

GPR78 antibody

Anti-GPR78 antibody IHC of human placenta, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €345.00
  OriGene Technologies, Inc.

GPR78 antibody

WB Suggested Anti-GPR78 Antibody; Titration: 1.0 ug/ml; Positive Control: OVCAR-3 Whole Cell Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GPR78 antibody

WB Suggested Anti-GPR78 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal kidney Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GPR78 antibody

Immunohistochemistry-Paraffin: GPR78 Antibody [NBP1-86467] Immunohistochemical staining of human pancreas shows distinct cytoplasmic and membranous positivity in intercalated ducts. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

GPR78 antibody

Pituitary Rabbit Hu P
50 µl / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GPR78

GPR78 Human
2 µg / €450.00
  Abnova Taiwan Corp.

GPR78

GPR78 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

8 Item(s)

per page
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