Granulins (GRN) antibody

Principal name

Granulins (GRN) antibody

Alternative names for Granulins (GRN) antibody

GRN, Granulins, Proepithelin, PEPI

SwissProt ID

P23785 (Rat), P28797 (Cavpo), P28798 (Mouse), P28799 (Human)

Gene ID

2896 (GRN), 29143 (Grn)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Mky (Monkey), Bov (Bovine), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P)

Background of Granulins (GRN) antibody

Granulin, also known as Proepithelin(PEPI) is a protein that in humans is encoded by the GRN gene. This gene is mapped to 17q21.31. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

General readings

Ghetti B, Spina S, Murrell JR, Huey ED, Pietrini P, Sweeney B, Wassermann EM Keohane C, Farlow MR, Grafman J
In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
Neurodegener Dis. 2008;5(3-4):215-7.
PMID: 18322394

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Granulin-3 (248-259) antibody

AP31954PU-N Granulin-3 antibody staining of A431 lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Granulins (GRN) antibody

  Rabbit Polyclonal Granulin Antibody  
Immunohistochemical staining of human epididymis shows strong cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Can, Hu, Mky, Ms E, ICC/IF, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Granulins (GRN) antibody

  GRN mouse monoclonal antibody, clone OTI4B9 (formerly 4B9)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807349)(1:150) Mouse IgG1 OTI4B9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granulins (GRN) antibody

  GRN mouse monoclonal antibody, clone OTI3H6  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807350)(1:150) Mouse IgG1 OTI3H6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granulins (GRN) antibody

  GRN mouse monoclonal antibody, clone OTI3B3 (formerly 3B3)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807351)(1:150) Mouse IgG2a OTI3B3 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granulins (GRN) antibody

  GRN mouse monoclonal antibody, clone OTI1F9 (formerly 1F9)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807352) Mouse IgG1 OTI1F9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granulins (GRN) antibody

  GRN mouse monoclonal antibody, clone OTI2F4 (formerly 2F4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-GRN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA807476) Mouse IgG1 OTI2F4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granulins (GRN) antibody

  Goat Anti-Granulin / GRN Antibody  
TA305781 (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Granulins (GRN) antibody

  Rabbit polyclonal GRN Antibody (C-term)  
GRN Antibody (C-term) (Cat. #TA325165) western blot analysis in A2058,HepG2,HL-60,T47D cell line lysates (35ug/lane).This demonstrates the GRN antibody detected the GRN protein (arrow). Rabbit IgG Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Granulins (GRN) antibody

  Rabbit anti-GRN Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using GRN antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Granulins (GRN) antibody

  Rabbit Polyclonal Anti-GRN Antibody  
Host: Rabbit; Target Name: GRN; Sample Tissue: Thyroid Tumor lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

GRN - human gene knockout kit via CRISPR

GRN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRN - human gene knockout kit via CRISPR

GRN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRN - human gene knockout kit via CRISPR

GRN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRN - human gene knockout kit via CRISPR

GRN - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Granulins (GRN)

  Recombinant protein of human granulin (GRN)  
Granulins (GRN) Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ELISA Kits

Catalog No.    

Human Progranulin ELISA Kit

Human Progranulin ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

OmniKine™ Human Progranulin ELISA Kit

OmniKine™ Human Progranulin ELISA Kit  
96 Tests / €440.00
  Assay Biotech

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRN (mGFP-tagged) - Human granulin (GRN), 200 uL, >10^7 TU/mL

Lenti ORF particles, GRN (mGFP-tagged) - Human granulin (GRN), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRN (Myc-DDK tagged) - Human granulin (GRN) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRN (Myc-DDK tagged) - Human granulin (GRN) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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