Granzyme B (GZMB) antibody

Principal name

Granzyme B (GZMB) antibody

Alternative names for Granzyme B (GZMB) antibody

Granzyme-2, CGL1, CTSGL1, CSPB, CTLA1, CTLA-1, GRB, SECT, Fragmentin-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Cathepsin G-like 1

SwissProt ID

P04187 (Mouse), P10144 (Human)

Gene ID

3002 (GZMB), 300284 (Alg13), 14939 (Gzmb)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Chimp (Chimpanzee), Prim (Primate), Bov (Bovine), Can (Canine), Por (Porcine)

Available hosts

Rabbit, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of Granzyme B (GZMB) antibody

Granzymes are exogenous serine proteinases (enzymes) that are released from cytoplasmic granules of cytotoxic lymphocytes (CTLs) and NK cells. The name "granzymes" is derived from: granules + enzymes. These granules contain next to granzymes other proteins including a poreforming protein (Perforin). Upon binding of the CTL to a target cell (by CTL-receptor and antigen-presenting MHC molecules on the target cell) the contents of the granules are released in the intercellular space where after perforine will "perforate" the target cell membrane by forming transmembrane pores. Through these pores the granzymes can now enter the cytosol of the target cell. Granzyme B activates the intracellular cascade of caspases finally resulting in the killing of the target cells. Percentages of the Granzyme A and B positive CTLs can be determined by flow cytometry and immunocytochemical methods for many disorders. Not all granzymes enter the target cell, part of them also "leak" in to the peripheral blood and other biological fluids. Detectable amounts of granzymes have been found to circulate in healthy volunteers. These soluble granzymes can be measured by ELISAs.

General readings

General / background references:Andrade F et al. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 8:451-60 (1998). PubMed PMID: 9586635
Cho MS et al. Granzyme B immunoreactivity in T/natural killer cell lymphomas. Yonsei Med J 38:285-93 (1997). PubMed PMID: 9409191
de Bruin PC et al. Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype. Histopathology 31:313-7 (1997). PubMed PMID: 9363445

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Granzyme B (GZMB) antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-GZMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505930) Mouse IgG2a OTIE6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Granzyme B (GZMB) antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-GZMB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505931) Mouse IgG1 OTI4E4 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Granzyme B (GZMB) antibody

Human tonsil stained with anti-Granzyme B antibody Rabbit Purified Can, Hu, Ms, Por, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Human tonsil stained with anti-Granzyme B antibody Rabbit Purified Can, Hu, Ms, Por, Rt P
1 ml / €490.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Human tonsil stained with anti-Granzyme B antibody Rabbit Purified Can, Hu, Ms, Por, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Western blot analysis of extracts from NIH/3T3 cells, using Granzyme B antibody (#TA312131).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Granzyme B (GZMB) antibody

Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using GZMB antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Granzyme B (GZMB) antibody

Western blot analysis of extracts of various cell lines, using GZMB antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Granzyme B (GZMB) antibody

Western blot analysis on NIH-3T3 cell lysate using Granzyme B Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Granzyme B (GZMB) antibody

Granzyme B (GZMB) Mouse IgG1 B18.1 Aff - Purified Hu C, F, IP, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Granzyme B (GZMB) Mouse IgG2a GrB-7 Supernatant Hu P, WB
5 ml / €1,700.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Granzyme B (GZMB) Mouse IgG2a GrB-7 Supernatant Hu P, WB
1 ml / €420.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Immunohistochemistry (IHC) analyzes of Granzyme B/H antibody (Cat.-No.: AP06147PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Granzyme B (GZMB) (N-term) antibody

Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P
50 µl / €470.00
  Acris Antibodies GmbH

Granzyme B (GZMB) (C-term) antibody

Western blot analysis of GZMB Antibody (C-term) (AP17448PU-N) in HL-60 cell line lysates (35 µg/lane). GZMB (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Granzyme B (GZMB) (N-term) antibody

Western blot analysis of GZMB antibody (N-term) (AP17449PU-N) in mouse stomach lysates (35 µg/lane). GZMB (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Figure.3: BOSC cells were transiently transfected with expression vectors for Granzyme A, B, K, or M. Expression of the constructs was tested with an anti-tag monoclonal antibody (green curves), an irrelevant monoclonal antibody served as negative control (black curves). For specificity testing, purified Granzyme B antibody was tested on all transfectants. A positive signal wasobtained only with Granzyme B transfected cells (red curves). Mouse IgG1 GM4C1 Purified Hu E, F
0.1 mg / €330.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Formalin fixed paraffin embedded human tonsil stained with Granzyme B antibody. DP105 Rabbit Purified Hu, Ms, Rt C, P
1 ml / €660.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Formalin fixed paraffin embedded human tonsil stained with Granzyme B antibody. DP105 Rabbit Purified Hu, Ms, Rt C, P
0.5 ml / €430.00
  Acris Antibodies GmbH

Granzyme B (GZMB) antibody

Granzyme B (GZMB) Mouse IgG2a GB7 Purified Hu P, WB
0.1 mg / €540.00
  Acris Antibodies GmbH

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