GRB10 / GRBIR antibody
Principal name
GRB10 / GRBIR antibody
Alternative names for GRB10 / GRBIR antibody
Grb-IR, KIAA0207, Growth factor receptor-bound protein 10, Insulin receptor-binding protein Grb-IR
Ncbi ID
9606, NP_001001549, NP_001001549.1, NP_005302, NM_005311, NM_001001549, NM_001001550, NP_001001555, NP_001001550, NP_001171100.1, NM_001177629, NM_010345
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)
Background of GRB10 / GRBIR antibody
Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine- containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
General readings
Liu F and Roth RA. Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function. Proc. Natl. Acad. Sci. USA 1995; 92:10287-91.



Lane 1: HEK293T whole cell lysate.
Lane 2: Raw364.7 whole cell lysate.
Lane 2: PC12 whole cell lysate.







Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AP32960PU-N | GRB10 / GRBIR antibody |
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Goat | Aff - Purified | Hu | WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
Acris recommends this product for Western blotting. |
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TA313962 | GRB10 / GRBIR antibody |
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Rabbit polyclonal GRB10 (Tyr67) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu | E, ICC/IF, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA319657 | GRB10 / GRBIR (C-term) antibody |
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Rabbit Polyclonal GRB10 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu, Ms, Rt | E, ICC/IF, WB |
0.1 mg /
€371.00
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OriGene Technologies, Inc. | |||||||
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TA322628 | GRB10 / GRBIR antibody |
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Anti-GRB10 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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|
OriGene Technologies, Inc. | |||||||
TA322629 | GRB10 / GRBIR antibody |
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Anti-GRB10 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, P |
0.1 ml /
€335.00
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|
OriGene Technologies, Inc. | |||||||
TA325016 | GRB10 / GRBIR antibody |
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Rabbit polyclonal GRB10 Antibody (N-term) | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.4 ml /
€410.00
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|
OriGene Technologies, Inc. | |||||||
AP20303PU-N | GRB10 / GRBIR antibody |
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Rabbit | Aff - Purified | Hu | ICC/IF, P, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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A1031-1 | GRB10 / GRBIR pTyr67 antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
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A1031-2 | GRB10 / GRBIR pTyr67 antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, WB |
0.1 mg /
€330.00
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Assay Biotech | |||||||
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B1031-1 | GRB10 / GRBIR antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, P, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
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B1031-2 | GRB10 / GRBIR antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, P, WB |
0.1 mg /
€330.00
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Assay Biotech | |||||||
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CRISPR
Catalog No. | Species | Donor Vector | |
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KN206853 | GRB10 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN206853BN | GRB10 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN206853LP | GRB10 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN206853RB | GRB10 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN307303 | Grb10 - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN307303BN | Grb10 - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN307303LP | Grb10 - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN307303RB | Grb10 - mouse gene knockout kit via CRISPR |
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Mouse | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP306853 | GRB10 / GRBIR (transcript variant 4) |
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Recombinant protein of human growth factor receptor-bound protein 10 (GRB10), transcript variant 4 | |||||
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Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
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OriGene Technologies, Inc. |