GRIN3B antibody

Principal name

GRIN3B antibody

Alternative names for GRIN3B antibody

NMDAR3B, NR3B, Glutamate [NMDA] receptor subunit 3B

SwissProt ID

O60391 (Human), Q8VHN2 (Rat), Q91ZU9 (Mouse)

Gene ID

116444 (GRIN3B), 170796 (Grin3b)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of GRIN3B antibody

The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinsonâ??s and Alzheimerâ??s disease. The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

General readings

Sedaghati, M., et al. Eur. J. Pharmacol. 633 (1-3), 50-54 (2010)
Saus, E., et al. J Psychiatr Res (2010) In press
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Liu, H.P., et al. Dement Geriatr Cogn Disord 28(6):521-527(2009)
Niemann, S., et al. Neurology 70(9):666-676(2008)

5 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GRIN3B (C-term) antibody

(0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GRIN3B antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1, 2. Anti-NMDA Receptor 3B (GluN3B) (extracellular) antibody, (1:200). 3, 4. Anti-NMDA Receptor 3B (GluN3B) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GRIN3B (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with GRIN3B Antibody (C-term) Cat.-No AP51956PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GRIN3B antibody

GRIN3B Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

GRIN3B antibody

GRIN3B Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

5 Item(s)

per page
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