GRIN3B antibody

Principal name

GRIN3B antibody

Alternative names for GRIN3B antibody

NMDAR3B, NR3B, Glutamate [NMDA] receptor subunit 3B

SwissProt ID

O60391 (Human), Q8VHN2 (Rat), Q91ZU9 (Mouse)

Gene ID

116444 (GRIN3B), 170796 (Grin3b), 170483

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of GRIN3B antibody

The NMDA receptors (NMDARs) are members of the glutamate receptor family of ion channels that also include the AMPA and Kaite receptors. The NMDA receptors are encoded by seven genes: one NMDAR1 (or NR1) subunit, four NR2 (NR2A-NR2D) and two NR3 (NR3A-NR3B) subunits. The functiol NMDA receptor appears to be a heterotetramer composed of two NMDAR1 and two NMDAR2 subunits. Whereas the NMDAR2 subunits that assemble with the NMDAR1 subunit can be either of the same kind (i.e. two NMDAR2A subunits) or different (one NMDAR2A with one NMDAR2B). NMDAR3 subunits can substitute the NMDAR2 subunits in their complex with the NMDAR1 subunit. The NMDAR is unique among ligand-gated ion channels in that it requires the simultaneous binding of two obligatory agonists: glycine and glutamate that bind to the NMDAR1 and NMDAR2 binding sites respectively. Another unique characteristic of the NMDA receptors is their dependence on membrane potential. At resting membrane potentials the channels are blocked by extracellular Mg2+. Neurol depolarization relieves the Mg2+ blockage and allows ion influx into the cells. NMDA receptors are strongly selective for Ca2+ influx differing from the other glutamate receptor ion channels that are non-selective cation channels. Ca2+ entry through the NMDAR regulates numerous downstream sigling pathways including long term potentiation (a molecular model of memory) and syptic plasticity that may underlie learning. In addition, the NMDA receptors have been implicated in a variety of neurological disorders including epilepsy, ischemic brain damage, Parkinsonâ??s and Alzheimerâ??s disease. The expression and function of NMDA receptors are modulated by a variety of factors including receptor trafficking to the sypses and interlization as well as phosphorylation and interaction with other intracellular proteins.

General readings

Sedaghati, M., et al. Eur. J. Pharmacol. 633 (1-3), 50-54 (2010)
Saus, E., et al. J Psychiatr Res (2010) In press
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Liu, H.P., et al. Dement Geriatr Cogn Disord 28(6):521-527(2009)
Niemann, S., et al. Neurology 70(9):666-676(2008)

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GRIN3B (C-term) antibody

  Goat Anti-GRIN3B Antibody  
(0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GRIN3B antibody

  Rabbit Polyclonal Anti-NMDA Receptor 3B (GluN3B) (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1, 2. Anti-NMDA Receptor 3B (GluN3B) (extracellular) antibody, (1:200). 3, 4. Anti-NMDA Receptor 3B (GluN3B) (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

GRIN3B (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with GRIN3B Antibody (C-term) Cat.-No AP51956PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

GRIN3B - human gene knockout kit via CRISPR

GRIN3B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

GRIN3B - human gene knockout kit via CRISPR

GRIN3B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIN3B - human gene knockout kit via CRISPR

GRIN3B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

GRIN3B - human gene knockout kit via CRISPR

GRIN3B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin3b - mouse gene knockout kit via CRISPR

Grin3b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Grin3b - mouse gene knockout kit via CRISPR

Grin3b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin3b - mouse gene knockout kit via CRISPR

Grin3b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grin3b - mouse gene knockout kit via CRISPR

Grin3b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRIN3B (mGFP-tagged) - Human glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (GRIN3B), 200 uL, >10^7 TU/mL

Lenti ORF particles, GRIN3B (mGFP-tagged) - Human glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (GRIN3B), 200 uL, >10^7 TU/mL  
200 µl / €2,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRIN3B (Myc-DDK tagged) - Human glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (GRIN3B) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRIN3B (Myc-DDK tagged) - Human glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (GRIN3B) , 200 uL, >10^7 TU/mL  
200 µl / €1,900.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grin3b (GFP-tagged) - Mouse glutamate receptor, ionotropic, NMDA3B (Grin3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin3b (GFP-tagged) - Mouse glutamate receptor, ionotropic, NMDA3B (Grin3b), 200 uL, >10^7 TU/mL  
200 µl / €1,780.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grin3b (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, NMDA3B (Grin3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin3b (Myc-DDK-tagged) - Mouse glutamate receptor, ionotropic, NMDA3B (Grin3b), 200 uL, >10^7 TU/mL  
200 µl / €1,600.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grin3b (GFP-tagged ORF) - Rat glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (Grin3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin3b (GFP-tagged ORF) - Rat glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (Grin3b), 200 uL, >10^7 TU/mL  
200 µl / €2,110.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grin3b (Myc-DDK-tagged ORF) - Rat glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (Grin3b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grin3b (Myc-DDK-tagged ORF) - Rat glutamate receptor, ionotropic, N-methyl-D-aspartate 3B (Grin3b), 200 uL, >10^7 TU/mL  
200 µl / €1,905.00
  OriGene Technologies, Inc.

17 Item(s)

per page
  • LinkedIn