GSK3 beta antibody

Principal name

GSK3 beta antibody

Alternative names for GSK3 beta antibody

GSK-3 beta, Glycogen synthase kinase-3 beta, GSK3B

SwissProt ID

P18266 (Rat), P49841 (Human), Q9WV60 (Mouse)

Gene ID

2932 (GSK3B), 84027 (Gsk3b), 56637

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Chk (Chicken), Mky (Monkey), Xen (Xenopus), Ze (Zebrafish), Frog, Sh (Sheep), Por (Porcine), African clawed frog, Prim (Primate)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F)

Background of GSK3 beta antibody

Glycogen synthase kise 3 (GSK3) is a proline-directed serine/threonine protein kise that was origilly identified for its role in glycogen metabolism; however, subsequently it was shown to serve pleiotropic functions, including embryonic development, gene transcription, and neurol cell function. Mammalian GSK has two isoforms encoded by distinct genes: GSK3A produces a 51-kD GSK3-alpha protein and GSK3B a 47-kD GSK3-beta protein. Phosphorylation of Tyr279/Tyr216 on GSK3alpha/beta is important for enzymatic activity, whereas ictivation of GSK3 can be achieved through phosphorylation of Ser21/Ser9 residues within the N-termil domain on GSK3-alpha/beta, respectively. Upstream kises PKA, AKT/PKB, PKC, p90RSK/MAPKAP and p70S6K are known to phosphorylate Ser9 of GSK3-beta. Furthermore, GSK3 is also regulated via interactions with WNT ligand and its receptor Frizzled/co-receptor LRP5/6, and this interaction releases GSK3 from a multi-protein complex formed by beta-catenin, axin, and adenomatous polyposis coli (APC), which prevents GSK3-mediated beta-catenin degradation and induces beta-catenin-dependent gene transcription. GSK3 is one of the few sigling mediators that play central roles in a diverse range of sigling pathways, including those activated by WNT, hedgehog, growth factors, cytokines, and G protein-coupled ligands. GSK3 dysregulation, particularly hyperactivation, with various pathological conditions, including diabetes mellitus, obesity, inflammation, neurological disorders, and tumorigenesis.

General readings

Castaño Z. et al.The neuron-specific isoform of glycogen synthase kinase-3β is required for axon growth. Journal of Neurochemistry, April 2010, Volume 113, Issue 1, pages 117–130.

  1. Quick-Filters:
  2. Highly Validated (3)

Items 1 to 20 of 63 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GSK3 beta antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using GSK3β antibody (AP02546PU-S or AP02546PU-N). Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

GSK3 beta antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using GSK3β antibody (AP02546PU-S or AP02546PU-N). Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

GSK3 beta antibody

Skeletal muscle, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

GSK3 beta antibody

  Rabbit Anti-Glycogen synthase kinase 3 B (GSK3B) (Ser9) Antibody (Phospho-Specific)  
Western blot of rat cortex lysate showing specific immunolabeling of the ~46k GSK3β  protein phosphorylated at Ser9 (control).  Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit polyclonal GSK3beta (Ab-9) antibody  
Western blot analysis of extracts from 293 cells treated with serum, using GSK3ß (Ab-9) Antibody antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit polyclonal GSK3beta (Ser9) antibody(Phospho-specific)  
Western blot analysis of extracts from COLO, using GSK3ß (Phospho-Ser9) AntibodyThe lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta (4-12) pSer9 antibody

  GSK3B / GSK3 Beta Rabbit Polyclonal (pSer9) Antibody  
Anti-GSK3B / GSK3 Beta antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Aff - Purified Hu E, ICC/IF, IP, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

GSK3 beta pSer9 antibody

  Rabbit polyclonal GSK3 Beta phospho S9 antibody  
WB using Rabbit-anti-GSK3B pS9 antibody at a 1:1,000 dilution. All lanes contain human 293T whole cell lysate showing a band at 47 kDa. Cells were serum starved for 24 h prior to extraction. Key: Lane 1 Control, Lane 2 treated with IGF-1 (100 ng/ml) for 20', lane 3 pre-treated with 10 uM LY294002 (selective PI3K inhibitor) and treated with IGF-1 (100 ng/ml) for 20'. Molecular weight markers confirm a MW of ~ 49 kDa. Use a 1:2,000 dilution of HRP Goat-a-Rabbit IgG  for detection. Rabbit Aff - Purified Hu E, IP, P, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Anti-GSK3B Rabbit Polyclonal Antibody  
Western blot analysis of Human small intestine stromal cancer tissue using TA323060 (GSK3B Antibody) at dilution 1/100 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Anti-GSK3B (Phospho-Tyr216) Rabbit Polyclonal Antibody  
Predicted band size: 46 kDa . Positive control: 293 cells treated with PMA lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1: untreated 293 cells lysate Lane2: 293 cells treated with PMA lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit polyclonal Mouse Gsk3b Antibody (N-term)  
Mouse Gsk3b Antibody (N-term) (Cat. #TA324570) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Gsk3b antibody detected the Gsk3b protein (arrow). Rabbit IgG Purified Hu, Ms, Rt P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit polyclonal Bi-Phospho-GSK3B(S21/29) Antibody  
The anti-Phospho-GSK3B-S21/29 Pab (Cat. #TA324769) is used in Western blot to detect Phospho-GSK3B-S21/29 in mouse thymus tissue lysate. Rabbit IgG Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit Polyclonal GSK3 beta Antibody  
Western blot analysis of GSK3 beta expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit Polyclonal GSK3 beta (Ser9) Antibody (Phospho-specific)  
Western blot analysis of GSK3 beta phosphorylation expression in EGF treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit polyclonal GSK-3Beta Antibody  
Western blot analysis of GSK-3Beta in a cell line mix, using a 1:1000 dilution of the antibody Rabbit Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit Polyclonal anti-GSK-3ß Antibody  
Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-GSK 3ß antibody. Proteins were visualized using a donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system. Rabbit IgG Poly6042 Purified Hu, Ms WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Phospho-GSK3B-S9 Rabbit Polyclonal Antibody  
GSK3 beta Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Mouse Monoclonal GSK-3 beta Antibody (3D10)  
Western Blot: GSK3 beta Antibody (3D10) [TA336772] - Western blot analysis using GSK3 beta mouse mAb against A549 (1), K562 (2), PC-12 (3), NIH/3T3 (4), and HEK293 (5) cell lysates. Mouse IgG2a 3D10 Purified Hu, Ms, Prim, Rt C, E, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta antibody

  Rabbit Polyclonal anti-GSK-3 Antibody  
Human Brain stained with anti-GSK-3 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

GSK3 beta (N-term) (incl. pos. control) antibody

GSK3 beta Mouse IgG1 11B9 Biotin Can, Hu, Ms, Rt E, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

Items 1 to 20 of 63 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  • LinkedIn