GTF3C2 / TFIIIC110 antibody

Principal name

GTF3C2 / TFIIIC110 antibody

Alternative names for GTF3C2 / TFIIIC110 antibody

TF3C-beta, KIAA0011, General transcription factor 3C polypeptide 2, Transcription factor IIIC subunit beta, Transcription factor IIIC 110 kDa subunit

SwissProt ID

Q8BL74 (Mouse), Q8WUA4 (Human)

Gene ID

2976 (GTF3C2)

Available reactivities

Hu (Human), Can (Canine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of GTF3C2 / TFIIIC110 antibody

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB", the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

General readings

Dumay-Odelot, H., et al. J. Biol. Chem. 282(23):17179-17189(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

GTF3C2 / TFIIIC110 antibody

WB Suggested Anti-GTF3C2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

GTF3C2 / TFIIIC110 antibody

Western blot(WB) analysis of TFIIIC110 antibody (Cat.-No.: AP06745PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

GTF3C2 / TFIIIC110 (N-term) antibody

Western blot analysis of GTF3C2 / TFIIIC110 Antibody (N-term) Cat.-No AP51974PU-N in HL-60 cell line lysates (35ug/lane). This demonstrates the GTF3C2 antibody detected the GTF3C2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

GTF3C2 / TFIIIC110 antibody

Immunofluorescence of purified MaxPab antibody to GTF3C2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

GTF3C2 / TFIIIC110 antibody

Immunofluorescence of purified MaxPab antibody to GTF3C2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

GTF3C2 / TFIIIC110 antibody

GTF3C2 / TFIIIC110 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

GTF3C2 / TFIIIC110 antibody

Western Blot analysis of GTF3C2 expression in transfected 293T cell line (H00002976-T02) by GTF3C2 MaxPab polyclonal antibody.

Lane 1: GTF3C2 transfected lysate(100.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

GTF3C2 / TFIIIC110 antibody

Immunoperoxidase of monoclonal antibody to GTF3C2 on formalin-fixed paraffin-embedded human colon tissue. [antibody concentration 1ug/ml] Mouse IgG1 1C6-2B8 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

GTF3C2 / TFIIIC110 antibody

Western blot analysis of extracts from HepG2/COLO205/HuvEc cells, using TF3C2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

GTF3C2 / TFIIIC110 antibody

Western blot analysis of extracts from HepG2/COLO205/HuvEc cells, using TF3C2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

GTF3C2 / TFIIIC110 antibody

r-GTF3C2; WB Suggested Anti-GTF3C2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Transfected 293T; GTF3C2 antibody - middle region (ARP31914_P050) in r-GTF3C2 cells using Western Blot Rabbit Aff - Purified Can, Hu WB
50 µg / €350.00
  AVIVA Systems Biology

GTF3C2 / TFIIIC110 antibody

Immunohistochemistry-Paraffin: GTF3C2 Antibody [NBP1-83062] - Immunohistochemical staining of human duodenum shows strong positivity in smooth muscle cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

GTF3C2 / TFIIIC110 (transcript variant 1)

GTF3C2 / TFIIIC110 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

GTF3C2 / TFIIIC110 (transcript variant 2)

GTF3C2 / TFIIIC110 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Antibody Pairs

Catalog No.    

GTF3C2 (Human) IP-WB Antibody Pair

GTF3C2 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

GTF3C2 (Human) Matched Antibody Pair

GTF3C2 (Human) Matched Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

GTF3C2 293T Cell Transient Overexpression Lysate(Denatured)

GTF3C2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

GTF3C2 overexpression lysate

GTF3C2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

GTF3C2 overexpression lysate

GTF3C2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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